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Volumn 17, Issue 4, 2011, Pages 473-485

Enzymatic and toxinological activities of Hypnale hypnale (hump-nosed pit viper) venom and its fractionation by ion exchange high performance liquid chromatography

Author keywords

Enzymes; Fibrinogen; Hypnale hypnale; Nephrotoxicity; Toxins; Venom

Indexed keywords

ALKALINE PHOSPHATASE; AMINO ACID OXIDASE; HYALURONIDASE; PHOSPHOLIPASE A2; PROTEINASE; VIPER VENOM;

EID: 83155168202     PISSN: 16789180     EISSN: 16789199     Source Type: Journal    
DOI: 10.1590/S1678-91992011000400015     Document Type: Article
Times cited : (25)

References (66)
  • 1
    • 19544394601 scopus 로고    scopus 로고
    • Snake toxins and hemostasis
    • Fox JW, Serrano SM. Snake toxins and hemostasis. Toxicon. 2005;45(1):951-1181.
    • (2005) Toxicon , vol.45 , Issue.1 , pp. 951-1181
    • Fox, J.W.1    Serrano, S.M.2
  • 2
    • 0032402107 scopus 로고    scopus 로고
    • Snake venoms and the hemostatic system
    • Markland FS. Snake venoms and the hemostatic system. Toxicon. 1998;36(1):1749-800.
    • (1998) Toxicon , vol.36 , Issue.1 , pp. 1749-1800
    • Markland, F.S.1
  • 3
    • 13844310831 scopus 로고    scopus 로고
    • A multifaceted analysis of viperid snake venoms by two-dimensional gel electrophoresis: An approach to understanding venom proteomics
    • Serrano SM, Shannon JD, Wang D, Camargo AC, Fox JW. A multifaceted analysis of viperid snake venoms by two-dimensional gel electrophoresis: an approach to understanding venom proteomics. Proteomics. 2005;5(2):501-10.
    • (2005) Proteomics , vol.5 , Issue.2 , pp. 501-510
    • Serrano, S.M.1    Shannon, J.D.2    Wang, D.3    Camargo, A.C.4    Fox, J.W.5
  • 4
    • 36148976495 scopus 로고    scopus 로고
    • Snake venomics. Strategy and applications
    • Calvete JJ, Juarez P, Sanz L. Snake venomics. Strategy and applications. J Mass Spectrom. 2007;42(11):1405-14.
    • (2007) J Mass Spectrom , vol.42 , Issue.11 , pp. 1405-1414
    • Calvete, J.J.1    Juarez, P.2    Sanz, L.3
  • 5
    • 31844435709 scopus 로고    scopus 로고
    • Early evolution of the venom system in lizards and snakes
    • Fry BG, Vidal N, Norman JA, Vonk FJ, Scheib H, Ramjan SF, et al. Early evolution of the venom system in lizards and snakes. Nature. 2006;439(7076):584-8.
    • (2006) Nature , vol.439 , Issue.7076 , pp. 584-588
    • Fry, B.G.1    Vidal, N.2    Norman, J.A.3    Vonk, F.J.4    Scheib, H.5    Ramjan, S.F.6
  • 6
    • 0036293280 scopus 로고    scopus 로고
    • Colubroid systematics: Evidence of an early appearance of the venom apparatus followed by extensive evolutionary tinkering
    • Vidal N. Colubroid systematics: evidence of an early appearance of the venom apparatus followed by extensive evolutionary tinkering. J Toxicol Toxin Rev. 2002; 21(1):21-41.
    • (2002) J Toxicol Toxin Rev , vol.21 , Issue.1 , pp. 21-41
    • Vidal, N.1
  • 7
    • 84855239549 scopus 로고    scopus 로고
    • World Health Organization, WHO: Geneva; 2009 [cited 2009 Aug 12]. Available from
    • World Health Organization. Neglected tropical disease: snakebite [Internet]. WHO: Geneva; 2009 [cited 2009 Aug 12]. Available from: http://www.who.int/neglected_diseases/diseases/snakebites/en/index.html.
    • Neglected Tropical Disease: Snakebite [Internet]
  • 9
    • 33745617121 scopus 로고    scopus 로고
    • Confronting the neglected problem of snake bite envenoming: The need for a global partnership
    • Gutiérrez JM, Theakston RDG, Warrel DA. Confronting the neglected problem of snake bite envenoming: the need for a global partnership. PLoS Med. 2006;3(6):e150.
    • (2006) PLoS Med , vol.3 , Issue.6
    • Gutiérrez, J.M.1    Theakston, R.D.G.2    Warrel, D.A.3
  • 11
    • 53549103552 scopus 로고    scopus 로고
    • Frequent and potentially fatal envenoming by hump-nosed pit vipers (Hypnale hypnale and H. nepa) in Sri Lanka: Lack of effective antivenom
    • Ariaratnam CA, Thuraisingam V, Kularatne SA, Sheriff MH, Theakston RD, de Silva A, et al. Frequent and potentially fatal envenoming by hump-nosed pit vipers (Hypnale hypnale and H. nepa) in Sri Lanka: lack of effective antivenom. Trans R Soc Trop Med Hyg. 2008;102(11):1120-6.
    • (2008) Trans R Soc Trop Med Hyg , vol.102 , Issue.11 , pp. 1120-1126
    • Ariaratnam, C.A.1    Thuraisingam, V.2    Kularatne, S.A.3    Sheriff, M.H.4    Theakston, R.D.5    de Silva, A.6
  • 12
    • 33750495163 scopus 로고    scopus 로고
    • First authenticated cases of life-threatening envenoming by the hump-nosed pit viper (Hypnale hypnale) in India
    • Joseph JK, Simpson ID, Menon NC, Jose MP, Kulkarni KJ, Raghavendra GB, et al. First authenticated cases of life-threatening envenoming by the hump-nosed pit viper (Hypnale hypnale) in India. Trans R Soc Trop Med Hyg. 2007;101(1):85-90.
    • (2007) Trans R Soc Trop Med Hyg , vol.101 , Issue.1 , pp. 85-90
    • Joseph, J.K.1    Simpson, I.D.2    Menon, N.C.3    Jose, M.P.4    Kulkarni, K.J.5    Raghavendra, G.B.6
  • 16
    • 0003852508 scopus 로고
    • Colombo, Sri Lanka: [Colombo Museum] H. R. Cottle. Government Printer, Ceylon
    • Wall F. Ophidia Taprobanica or the snakes of Ceylon. Colombo, Sri Lanka: [Colombo Museum] H. R. Cottle, Government Printer, Ceylon; 1921. 582 p.
    • (1921) Ophidia Taprobanica Or the Snakes of Ceylon , pp. 582
    • Wall, F.1
  • 18
    • 0028596004 scopus 로고
    • Envenomation by the hump-nosed pit viper (Hypnale hypnale)
    • Sellahawa KH, Kumararatne MP. Envenomation by the hump-nosed pit viper (Hypnale hypnale). Am J Trop Med Hyg. 1994;51(1):823-5.
    • (1994) Am J Trop Med Hyg , vol.51 , Issue.1 , pp. 823-825
    • Sellahawa, K.H.1    Kumararatne, M.P.2
  • 19
    • 0028217436 scopus 로고
    • Haemostatic dysfunction and acute renal failure following envenoming by Merrem's hump-nosed viper (Hypnale hypnale) in Sri Lanka: First authenticated case
    • de Silva A, Wijekoon AS, Jayasena L, Abeysekara CK, Bao CX, Hutton RA, et al. Haemostatic dysfunction and acute renal failure following envenoming by Merrem's hump-nosed viper (Hypnale hypnale) in Sri Lanka: first authenticated case. Trans R Soc Trop Med Hyg. 1994;88(2):209-12.
    • (1994) Trans R Soc Trop Med Hyg , vol.88 , Issue.2 , pp. 209-212
    • de Silva, A.1    Wijekoon, A.S.2    Jayasena, L.3    Abeysekara, C.K.4    Bao, C.X.5    Hutton, R.A.6
  • 20
    • 70349739426 scopus 로고    scopus 로고
    • Syndromic approach to treatment of snake bite in Sri Lanka based on results of a prospective national hospital-based survey of patients envenomed by identified snakes
    • Ariaratnam CA, Sheriff MH, Arambepola C, Theakston RD, Warrell DA. Syndromic approach to treatment of snake bite in Sri Lanka based on results of a prospective national hospital-based survey of patients envenomed by identified snakes. Am J Trop Med Hyg. 2009;81(4):725-31.
    • (2009) Am J Trop Med Hyg , vol.81 , Issue.4 , pp. 725-731
    • Ariaratnam, C.A.1    Sheriff, M.H.2    Arambepola, C.3    Theakston, R.D.4    Warrell, D.A.5
  • 21
    • 0031780320 scopus 로고    scopus 로고
    • Excessive fibrinolysis: The coagulopathy following Merrem's hump-nosed viper (Hypnale hypnale) bites
    • Premawardena AP, Seneviratne SL, Gunatilake SB, de Silva HJ. Excessive fibrinolysis: the coagulopathy following Merrem's hump-nosed viper (Hypnale hypnale) bites. Am J Trop Med Hyg. 1998;58(1):821-3.
    • (1998) Am J Trop Med Hyg , vol.58 , Issue.1 , pp. 821-823
    • Premawardena, A.P.1    Seneviratne, S.L.2    Gunatilake, S.B.3    de Silva, H.J.4
  • 23
    • 78650984561 scopus 로고    scopus 로고
    • Cross neutralization of Hypnale hypnale (hump-nosed pit viper) venom by polyvalent and monovalent Malayan pit viper antivenoms in vitro and in a rodent model
    • Tan CH, Leong PK, Fung SY, Sim SM, Ponnudurai G, Ariaratnam C, et al. Cross neutralization of Hypnale hypnale (hump-nosed pit viper) venom by polyvalent and monovalent Malayan pit viper antivenoms in vitro and in a rodent model. Acta Trop. 2011;117(2):119-24.
    • (2011) Acta Trop , vol.117 , Issue.2 , pp. 119-124
    • Tan, C.H.1    Leong, P.K.2    Fung, S.Y.3    Sim, S.M.4    Ponnudurai, G.5    Ariaratnam, C.6
  • 24
    • 0022336163 scopus 로고
    • A CIOMS ethical code for animal experimentation
    • Howard-Jones NA. A CIOMS ethical code for animal experimentation. WHO Chronicle. 1985;39(1):51-6.
    • (1985) WHO Chronicle , vol.39 , Issue.1 , pp. 51-56
    • Howard-Jones, N.A.1
  • 25
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1):248-54.
    • (1976) Anal Biochem , vol.72 , Issue.1 , pp. 248-254
    • Bradford, M.M.1
  • 26
    • 0000795704 scopus 로고
    • Crystalline soybean trypsin inhibitor II. General properties
    • Kunitz M. Crystalline soybean trypsin inhibitor II. General properties. J Gen Physiol. 1947;30(1):291-310.
    • (1947) J Gen Physiol , vol.30 , Issue.1 , pp. 291-310
    • Kunitz, M.1
  • 27
    • 0023947874 scopus 로고
    • Acidimetric assay for phospholipase A using egg yolk suspension susbtrate
    • Tan NH, Tan CS. Acidimetric assay for phospholipase A using egg yolk suspension susbtrate. Anal Biochem. 1988;170(1):282-8.
    • (1988) Anal Biochem , vol.170 , Issue.1 , pp. 282-288
    • Tan, N.H.1    Tan, C.S.2
  • 28
    • 0015521759 scopus 로고
    • Studies on the active site of IRC-50 arvin, the purified coagulant enzyme from Agkistrodon rhodostoma venom
    • Collins JP, Jones JG. Studies on the active site of IRC-50 arvin, the purified coagulant enzyme from Agkistrodon rhodostoma venom. Eur J Biochem. 1972;26(4):510-7.
    • (1972) Eur J Biochem , vol.26 , Issue.4 , pp. 510-517
    • Collins, J.P.1    Jones, J.G.2
  • 29
    • 84995190574 scopus 로고
    • Lee CY. Chemical studies of Formosan cobra (Naja naja atra) venom. Part 1. Chromatographic separation of crude venom on CM-Sephadex and preliminary characterization of its components
    • Lo TB, Chen CH, Lee CY. Chemical studies of Formosan cobra (Naja naja atra) venom. Part 1. Chromatographic separation of crude venom on CM-Sephadex and preliminary characterization of its components. J Chinese Chem Soc, Ser II. 1969;13(1):25-37.
    • (1969) J Chinese Chem Soc, Ser II , vol.13 , Issue.1 , pp. 25-37
    • Lo, T.B.1    Chen, C.H.2
  • 30
    • 0000131386 scopus 로고
    • In: Colowick SP, Kaplan NO, Editors. Methods In Enzymology. New York: Academic Press
    • Heppel LA, Hilmore RJ. 5'-Nucleotidase. In: Colowick SP, Kaplan NO, editors. Methods in enzymology. New York: Academic Press; 1955. 547 p. 2 vol.
    • (1955) 5'-Nucleotidase. Methods in enzymology , vol.2 , pp. 547
    • Heppel, L.A.1    Hilmore, R.J.2
  • 31
    • 4244120872 scopus 로고
    • Microdetermination of phosphorus
    • Chen PS, Toribara TY, Warner H. Microdetermination of phosphorus. Anal Chem. 1956;28(1):1756-8.
    • (1956) Anal Chem , vol.28 , Issue.1 , pp. 1756-1758
    • Chen, P.S.1    Toribara, T.Y.2    Warner, H.3
  • 32
    • 0020397002 scopus 로고
    • Purification and partial characterization of hyaluronidase from five pace snake (Agkistrodon acutus) venom
    • Xu X, Wang XS, Xi XT, Liu J, Huang J, Lu ZX. Purification and partial characterization of hyaluronidase from five pace snake (Agkistrodon acutus) venom. Toxicon. 1982;20(1):973-81.
    • (1982) Toxicon , vol.20 , Issue.1 , pp. 973-981
    • Xu, X.1    Wang, X.S.2    Xi, X.T.3    Liu, J.4    Huang, J.5    Lu, Z.X.6
  • 33
    • 0022606220 scopus 로고
    • Enzymatic activities of Calloselasma rhodostoma (Malayan pit viper) venom
    • Tan NH, Kanthimathi MS, Tan CS. Enzymatic activities of Calloselasma rhodostoma (Malayan pit viper) venom. Toxicon. 1986;24(1):626-30.
    • (1986) Toxicon , vol.24 , Issue.1 , pp. 626-630
    • Tan, N.H.1    Kanthimathi, M.S.2    Tan, C.S.3
  • 34
    • 0004116672 scopus 로고
    • 2nd ed. Cambridge: Cambridge University Press
    • Finney DJ. Probit Analysis. 2nd ed. Cambridge: Cambridge University Press; 1952. 3148 p.
    • (1952) Probit Analysis , pp. 3148
    • Finney, D.J.1
  • 35
    • 0021061641 scopus 로고
    • Development of simple standard assay procedures for the characterization of snake venoms
    • Theakston RD, Reid HA. Development of simple standard assay procedures for the characterization of snake venoms. Bull WHO. 1983;61(1):949-56.
    • (1983) Bull WHO , vol.61 , Issue.1 , pp. 949-956
    • Theakston, R.D.1    Reid, H.A.2
  • 36
    • 0034029451 scopus 로고    scopus 로고
    • Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica
    • Bogarin G, Morais JF, Yamaguchi IK, Stephano MA, Marcelino JR, Nishikawa AK, et al. Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica. Toxicon. 2000;38(1):1429-41.
    • (2000) Toxicon , vol.38 , Issue.1 , pp. 1429-1441
    • Bogarin, G.1    Morais, J.F.2    Yamaguchi, I.K.3    Stephano, M.A.4    Marcelino, J.R.5    Nishikawa, A.K.6
  • 37
    • 0029983528 scopus 로고    scopus 로고
    • The toxinology of Calloselasma rhodostoma (Malayan pit viper) venom
    • Tan NH, Ponnudurai G. The toxinology of Calloselasma rhodostoma (Malayan pit viper) venom. J Toxicol Toxin Rev. 1996;15:1-17.
    • (1996) J Toxicol Toxin Rev , vol.15 , pp. 1-17
    • Tan, N.H.1    Ponnudurai, G.2
  • 38
    • 71649115693 scopus 로고    scopus 로고
    • Isolation and characterization of the thrombin-like enzyme from Cryptelytrops purpureomaculatus venom
    • Tan NH. Isolation and characterization of the thrombin-like enzyme from Cryptelytrops purpureomaculatus venom. Comp Biochem Physiol C Toxicol Pharmacol. 2010;151(1):131-6.
    • (2010) Comp Biochem Physiol C Toxicol Pharmacol , vol.151 , Issue.1 , pp. 131-136
    • Tan, N.H.1
  • 40
    • 35548979180 scopus 로고
    • Acute toxicity: The determination of LD50
    • In: Turner RA, editor, New York: Academic Press
    • Turner RA. Acute toxicity: the determination of LD50. In: Turner RA, editor. Screening methods in pharmacology. New York: Academic Press; 1965. 300 p.
    • (1965) Screening Methods In Pharmacology , pp. 300
    • Turner, R.A.1
  • 41
    • 0003277484 scopus 로고
    • Biochemical characterization of snake venoms
    • In: Gopalakrishnakone P, Tan CK, editors, Singapore: Venom & Toxin research group
    • Tan NH, Ponnudurai G. Biochemical characterization of snake venoms. In: Gopalakrishnakone P, Tan CK, editors. Recent advances in toxinology research. Singapore: Venom & Toxin research group; 1992. 210-59 p.
    • (1992) Recent Advances In Toxinology Research , pp. 210-259
    • Tan, N.H.1    Ponnudurai, G.2
  • 42
    • 0002556781 scopus 로고    scopus 로고
    • Phospholipase A2: A complex multifunctional protein puzzle
    • In: Kini RM, editor, Chichester, England: John Wiley & Sons
    • Kini RM. Phospholipase A2: a complex multifunctional protein puzzle. In: Kini RM, editor. Venom phospholipase A2 enzymes: structure, function and mechanism. Chichester, England: John Wiley & Sons; 1997. 1-28 p.
    • (1997) Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism , pp. 1-28
    • Kini, R.M.1
  • 43
    • 1042275605 scopus 로고    scopus 로고
    • Excitement ahead: Structure, function and mechanism of snake venom phospholipase A2 enzymes
    • Kini RM. Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes. Toxicon. 2003;42(1):827-40.
    • (2003) Toxicon , vol.42 , Issue.1 , pp. 827-840
    • Kini, R.M.1
  • 44
    • 78049447227 scopus 로고    scopus 로고
    • Snake venom L-amino acid oxidase
    • Boca Raton, FL. In: Mackessy SP, editor, Taylor and Francis Group, CRC Press
    • Tan NH, Fung SY. Snake venom L-amino acid oxidase. In: Mackessy SP, editor. Handbook of venoms and toxins of reptiles. Boca Raton, FL: Taylor and Francis Group, CRC Press; 2009. 219-34 p.
    • (2009) Handbook of Venoms and Toxins of Reptiles , pp. 219-234
    • Tan, N.H.1    Fung, S.Y.2
  • 45
    • 19544382337 scopus 로고    scopus 로고
    • Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases
    • Fox JW, Serrano SMT. Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon. 2005;45(1):969-85.
    • (2005) Toxicon , vol.45 , Issue.1 , pp. 969-985
    • Fox, J.W.1    Serrano, S.M.T.2
  • 46
    • 2342462926 scopus 로고    scopus 로고
    • Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom
    • Girish KS, Shashidharamurthy R, Nagaraju S, Gowda TV, Kemparaju K. Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom. Biochimie. 2004;86(1):193-202.
    • (2004) Biochimie , vol.86 , Issue.1 , pp. 193-202
    • Girish, K.S.1    Shashidharamurthy, R.2    Nagaraju, S.3    Gowda, T.V.4    Kemparaju, K.5
  • 47
    • 0002914901 scopus 로고    scopus 로고
    • Phylogenetic relationships of the 'Agkistrodon complex' based on mitochondrial DNA sequence
    • Parkinson CL, Moody SM, Ahiquiet JE. Phylogenetic relationships of the 'Agkistrodon complex' based on mitochondrial DNA sequence. Symp Zool Soc London. 1997;70(1):63-78.
    • (1997) Symp Zool Soc London , vol.70 , Issue.1 , pp. 63-78
    • Parkinson, C.L.1    Moody, S.M.2    Ahiquiet, J.E.3
  • 48
    • 0032086565 scopus 로고    scopus 로고
    • Weighting and congruence: A case study based on three mitochondrial genes in pitvipers
    • Vidal N, Lecointre G. Weighting and congruence: a case study based on three mitochondrial genes in pitvipers. Mol Phylogenet Evol. 1998;9(3):366-74.
    • (1998) Mol Phylogenet Evol , vol.9 , Issue.3 , pp. 366-374
    • Vidal, N.1    Lecointre, G.2
  • 49
    • 0033212953 scopus 로고    scopus 로고
    • Purification and characterization of the venom phospholipase A2 from Asian monotypic Crotalinae snakes
    • Wang YM, Liew YF, Chang KY, Tsai IH. Purification and characterization of the venom phospholipase A2 from Asian monotypic Crotalinae snakes. J Nat Toxins. 1999;8(3):331-40.
    • (1999) J Nat Toxins , vol.8 , Issue.3 , pp. 331-340
    • Wang, Y.M.1    Liew, Y.F.2    Chang, K.Y.3    Tsai, I.H.4
  • 50
    • 79953271352 scopus 로고    scopus 로고
    • Snake venom nucleases, nucleotidases, and phosphomonoesterases
    • Boca Raton, FL. In: Mackessy SP, editor, Taylor and Francis Group, CRC Press
    • Dhananjaya BL, Vishwanath BS, D'Souza JM. Snake venom nucleases, nucleotidases, and phosphomonoesterases. In: Mackessy SP, editor. Handbook of venoms and toxins of reptiles. Boca Raton, FL: Taylor and Francis Group, CRC Press; 2009. 155-71 p.
    • (2009) Handbook of Venoms and Toxins of Reptiles , pp. 155-171
    • Dhananjaya, B.L.1    Vishwanath, B.S.2    D'souza, J.M.3
  • 51
    • 0007491381 scopus 로고
    • Zootoxicological properties of venom phosphodiesterase
    • Russell FE, Buess FW, Woo MY. Zootoxicological properties of venom phosphodiesterase. Toxicon. 1963;1(1):99-108.
    • (1963) Toxicon , vol.1 , Issue.1 , pp. 99-108
    • Russell, F.E.1    Buess, F.W.2    Woo, M.Y.3
  • 52
    • 0007575469 scopus 로고
    • Studies on sea snake venom. VI. Pharmacological properties of Laticauda semifasciata venom and purification of toxic components, acid phosphomonoesterase and phospholipase A in the venom
    • Uwatoko-Setoguchi Y. Studies on sea snake venom. VI. Pharmacological properties of Laticauda semifasciata venom and purification of toxic components, acid phosphomonoesterase and phospholipase A in the venom. Acta Med Univ Kagoshima. 1970;12(1):73-96.
    • (1970) Acta Med Univ Kagoshima , vol.12 , Issue.1 , pp. 73-96
    • Uwatoko-Setoguchi, Y.1
  • 53
    • 0002370964 scopus 로고
    • L-Amino acid oxidase
    • In: Lee CY, editor, Berlin: Springer-Verlag
    • Iwanaga S, Suzuki T. L-Amino acid oxidase. In: Lee CY, editor. Handbook of experimental pharmacology. Berlin: Springer-Verlag; 1979. 75-84 p.
    • (1979) Handbook of Experimental Pharmacology , pp. 75-84
    • Iwanaga, S.1    Suzuki, T.2
  • 54
    • 0014409040 scopus 로고
    • Inactivation of snake venom L-amino acid oxidase by freezing
    • Curti B, Massey V, Zmudha M. Inactivation of snake venom L-amino acid oxidase by freezing. J Biol Chem. 1968;24(1):2306-14.
    • (1968) J Biol Chem , vol.24 , Issue.1 , pp. 2306-2314
    • Curti, B.1    Massey, V.2    Zmudha, M.3
  • 55
    • 33846105870 scopus 로고    scopus 로고
    • Snake venom components and their applications in biomedicine
    • Koh DCI, Armugam A, Jeyaseelan K. Snake venom components and their applications in biomedicine. Cell Mol Life Sci. 2006;63(24):3030-41.
    • (2006) Cell Mol Life Sci , vol.63 , Issue.24 , pp. 3030-3041
    • Koh, D.C.I.1    Armugam, A.2    Jeyaseelan, K.3
  • 56
    • 0023010367 scopus 로고
    • Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties, and coagulant actions
    • Pirkle H, Theodor I, Miyada D, Simmons G. Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties, and coagulant actions. J Biol Chem. 1986; 261(1):8830-5.
    • (1986) J Biol Chem , vol.261 , Issue.1 , pp. 8830-8835
    • Pirkle, H.1    Theodor, I.2    Miyada, D.3    Simmons, G.4
  • 57
    • 50549199926 scopus 로고
    • Prolonged coagulation defect (defibrination syndrome) in Malayan viper bite
    • Reid HA, Chan KE, Thean PC. Prolonged coagulation defect (defibrination syndrome) in Malayan viper bite. Lancet. 1963;1(7282):621-6.
    • (1963) Lancet , vol.1 , Issue.7282 , pp. 621-626
    • Reid, H.A.1    Chan, K.E.2    Thean, P.C.3
  • 58
    • 0022600636 scopus 로고
    • Clinical significance of venom antigen levels in patients envenomed by the Malayan pit viper (Calloselasma rhodostoma)
    • Ho M, Warrell DA, Looareesuwan S, Phillips RE, Chanthavanich P, Karbwang J, et al. Clinical significance of venom antigen levels in patients envenomed by the Malayan pit viper (Calloselasma rhodostoma). Am J Trop Med Hyg. 1986;35(1):579-87.
    • (1986) Am J Trop Med Hyg , vol.35 , Issue.1 , pp. 579-587
    • Ho, M.1    Warrell, D.A.2    Looareesuwan, S.3    Phillips, R.E.4    Chanthavanich, P.5    Karbwang, J.6
  • 59
    • 83155192440 scopus 로고    scopus 로고
    • Retroperitoneal haemorrhage following a hump-nosed viper (Hypnale hypnale) bite: A late presentation
    • Sunanda H, Tilakaratne S, Coomaraswamy W. Retroperitoneal haemorrhage following a hump-nosed viper (Hypnale hypnale) bite: a late presentation. Galle Med J. 2010;15(1):41-2.
    • (2010) Galle Med J , vol.15 , Issue.1 , pp. 41-42
    • Sunanda, H.1    Tilakaratne, S.2    Coomaraswamy, W.3
  • 60
    • 46749119031 scopus 로고    scopus 로고
    • Snakebite nephrotoxicity in Asia
    • Kanjanabuch T, Sitprija V. Snakebite nephrotoxicity in Asia. Semin Nephrol. 2008; 28(1):363-72.
    • (2008) Semin Nephrol , vol.28 , Issue.1 , pp. 363-372
    • Kanjanabuch, T.1    Sitprija, V.2
  • 61
    • 54949090720 scopus 로고    scopus 로고
    • Animal toxins and the kidney
    • Sitprija V. Animal toxins and the kidney. Nat Clin Pract Nephrol. 2008;4(11):616-27.
    • (2008) Nat Clin Pract Nephrol , vol.4 , Issue.11 , pp. 616-627
    • Sitprija, V.1
  • 62
    • 0024566856 scopus 로고
    • Direct nephrotoxicity of Russell's viper venom demonstrated in the isolated perfused rat kidney
    • Ratcliffe PJ, Pukrittayakamee S, Ledingham JG, Warrell DA. Direct nephrotoxicity of Russell's viper venom demonstrated in the isolated perfused rat kidney. Am J Trop Med Hyg. 1989;40(3):312-9.
    • (1989) Am J Trop Med Hyg , vol.40 , Issue.3 , pp. 312-319
    • Ratcliffe, P.J.1    Pukrittayakamee, S.2    Ledingham, J.G.3    Warrell, D.A.4
  • 63
    • 0033213389 scopus 로고    scopus 로고
    • Pathophysiological effects of Russell's viper venom on renal function
    • Chaiyabutr N, Sitprija V. Pathophysiological effects of Russell's viper venom on renal function. J Nat Toxins. 1999;8(1):351-8.
    • (1999) J Nat Toxins , vol.8 , Issue.1 , pp. 351-358
    • Chaiyabutr, N.1    Sitprija, V.2
  • 66
    • 0018740828 scopus 로고
    • Bilateral cortical necrosis and calcification of the kidneys following snakebite: A case report
    • da Silva OA, López M, Godoy P. Bilateral cortical necrosis and calcification of the kidneys following snakebite: a case report. Clin Nephrol. 1979;11(3):136-9.
    • (1979) Clin Nephrol , vol.11 , Issue.3 , pp. 136-139
    • da Silva, O.A.1    López, M.2    Godoy, P.3


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