HERGCentral: A large database to store, retrieve, and analyze compound-human ether-à-go-go related gene channel interactions to facilitate cardiotoxicity assessment in drug development

Assay and Drug Development Technologies

Volumn 9, Issue 6, 2011, Pages 580-588

  Du, Fang ^a   Yu, Haibo ^a   Zou, Beiyan ^a   Babcock, Joseph ^a   Long, Shunyou ^a   Li, Min ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL HERG INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; CARDIOTOXICITY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CLINICAL RESEARCH; DRUG ACTIVITY; DRUG DESIGN; DRUG DETERMINATION; GENE EXPRESSION PROFILING; GENE LIBRARY; HEART ELECTROPHYSIOLOGY; HUMAN; ONLINE ANALYSIS; PROTEIN DATABASE; PROTEIN INTERACTION;

CARDIOTOXINS; DATABASES, FACTUAL; DRUG DISCOVERY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART DISEASES; HUMANS; INFORMATION STORAGE AND RETRIEVAL; STATISTICS AS TOPIC;

EID: 83055198527     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2011.0425     Document Type: Article

References (4)

1. Sanguinetti MC, Mitcheson JS: Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends Pharmacol Sci 2005;26:119-124. (Pubitemid 40313590)
2. Sanguinetti MC, Tristani-Firouzi M: hERG potassium channels and cardiac arrhythmia. Nature 2006;440:463-469.
3. Cormen TH, Leiserson CE, Rivest RL, Stein C: Introduction to Algorithms, 3rd edition. MIT Press, Cambridge, MA, 2009.
4. Zou B, Yu H, Babcock JJ, et al.: Profiling diverse compounds by fluxand electrophysiology-based primary screens for inhibition of human Ether-ago-go related gene potassium channels. Assay Drug Dev Technol 2010;8: 743-754.