Cyclic bisdesmosides from Actinostemma lobatum MAXIM (Cucurbitaceae) and their in vitro cytotoxicity

Fitoterapia

Volumn 83, Issue 1, 2012, Pages 147-152

  Li, Wei ^a   Cao, Jiaqing ^a   Tang, Yun ^a   Zhang, Linhui ^b   Xie, Qiangmin ^b   Shen, Huijuan ^b   Zhao, Yuqing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Actinostemma lobatum; Cyclic bisdesmosides; Cytotoxic activities; Triterpenoid sanponins

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACTINOSTEMMA LOBATUM MAXIM EXTRACT; ANTINEOPLASTIC AGENT; BISDESMOSIDE; DEXYLOSYLTUBEIMOSIDE III; HERBACEOUS AGENT; LOBATOSIDE B; LOBATOSIDE L; LOBATOSIDE M; TUBEIMOSIDE III; TUBEIMOSIDE V; UNCLASSIFIED DRUG;

ACTINOSTEMMA LOBATUM MAXIM; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CUCUMBER; DOSE RESPONSE; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CUCURBITACEAE; HUMANS; MOLECULAR STRUCTURE; SAPONINS;

CUCURBITACEAE;

EID: 83055180287     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2011.10.008     Document Type: Article

References (9)

1. State administration of traditional Chinese herbal editorial board Chinese Materia Medica 1999 Shanghai Science and Technology Publishers 4566
2. T. Fujiola, Y. Kashiwada, H. Okabe, and K. Mihashi Antitumor Agents 171. Cytotoxicities of lobatosides B, C, D and E, cyclic Bisdesmosides isolated from Actinostemma lobatum Maxim Bioorg Med Chem Lett 6 23 1996 2807 2810 (Pubitemid 26405653)
3. K.H. Kim, H.J. Lee, and J.H. Lee Blockade of glycoprotein IIb/IIIa mediates the antithrombotic activity of butanol fraction of Actinostemma lobatum Maxim J Ethnopharmacol 116 2008 431 438
4. R. Kasai, M. Miyakoshi, and R.L. Nie Saponins from Bolbostemma paniculatum: cyclic bisdesmosides, Tubeimosides II and III Phytochemistry 27 5 1988 1439 1446
5. Guang Cheng, Yun Zhang, and Xiang Zhang Tubeimoside V (1), a new cyclic bisdesmoside from tubers of Bolbostemma paniculatum, functions by inducing apoptosis in human glioblastoma U87MG cells Bioorg Med Chem Lett 16 2006 4575 4580 (Pubitemid 44094074)
6. Ivanova Antoaneta, Mikhova Bozhanka, Batsalova Tsvetelina, Dzhambazov Balik, and Kostova Ivanka New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity Fitoterapia 82 2011 282 287
7. Y. Su, K. Koike, T. Nikaido, J. Liu, J. Zheng, and D. Guo Conyzasaponins I-Q, nine new triterpenoid saponins from Conyza blinii J Nat Prod 66 2003 1593 1599 (Pubitemid 38036713)
8. T. Miyase, F.R. Melek, and T. Warashina Cytotoxic triterpenoid saponins acylated with monoterpenic acids from fruits of Gleditia caspica Desf Phytochemistry 71 2010 1908 1916
9. T. Fujioka, M. Iwamoto, and Y. Iwase Studies on the constituents of Actinostemma lobatum Maxim. V. Structures of lobatosides B, E, F and G, the dicrotalic acid esters of bayogenin bisdesmosides isolated from the herb Chem Pharm Bull 37 9 1989 2355 2360