Evidence that a panel of neurodegeneration biomarkers predicts vasospasm, infarction, and outcome in aneurysmal subarachnoid hemorrhage

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Siman, Robert ^a   Giovannone, Nicholas ^a   Toraskar, Nikhil ^a   Frangos, Suzanne ^a   Stein, Sherman C ^a   Levine, Joshua M ^a   Kumar, Monisha A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN PROTEIN; CALPAIN DERIVED ALPHA SPECTRIN C TERMINAL FRAGMENT; CALPAIN DERIVED ALPHA SPECTRIN N TERMINAL FRAGMENT; HYPOPHOSPHORYLATED NEUROFILAMENT H; NEURON SPECIFIC ENOLASE; PROTEIN 14 3 3 BETA; PROTEIN S100B; STRATIFIN; UBIQUITIN C TERMINAL HYDROLASE L1; UNCLASSIFIED DRUG;

ACUTE DISEASE; ADULT; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN ANGIOGRAPHY; BRAIN DAMAGE; BRAIN DYSFUNCTION; BRAIN INFARCTION; BRAIN VASOSPASM; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; DISEASE SEVERITY; ECHOGRAPHY; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; MALE; NERVE DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PREDICTION; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN FOLDING; SUBARACHNOID HEMORRHAGE; ADOLESCENT; CEREBROSPINAL FLUID; MIDDLE AGED; PATHOLOGY; TIME; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BRAIN INFARCTION; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE DEGENERATION; SUBARACHNOID HEMORRHAGE; TIME FACTORS; TREATMENT OUTCOME; VASOSPASM, INTRACRANIAL; YOUNG ADULT;

EID: 83055164442     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028938     Document Type: Article

References (35)

1. Bederson JB, Connolly ES Jr, Batjer HH, Dacey RG, Dion JE, et al. (2011) American Heart Association (2009) Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 40: 994-1025.
2. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, et al. (2011) American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 123: e18-e209.
3. Kassell NF, Sasaki T, Colohan AR, Nazar, (1985) Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16: 562-572.
4. Kramer A, Fletcher J, (2009) Do endothelin receptor antagonists prevent delayed neurological deficits and poor outcomes after aneurysmal subarachnoid hemorrhage?: a meta-analysis. Stroke 40: 3403-3406.
5. Vergouwen MDI, Vermeulen M, Gijn JV, Rinkel GJE, Wijdicks EF, et al. (2010) Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies. Stroke 41: 2391-2395.
6. Vergouwen MD, Etminan N, Ilodigwe D, Macdonald RL, (2011) Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab 31: 1545-1553.
7. Nylen K, Csajbok LZ, Ost M, Rashid A, Karlsson JE, et al. (2006) CSF neurofilament correlates with outcome after aneurysmal subarachnoid hemorrhage. Neurosci Lett 404: 132-136.
8. Nylen K, Csajbok LZ, Ost M, Rashid A, Blennow K, et al. (2007) Serum glial fibrillary acidic protein is related to focal brain injury and outcome after aneurysmal subarachnoid hemorrhage. Stroke 38: 1489-1494.
9. Petzold A, Keir G, Kay A, Kerr M, Thompson EJ, (2006) Axonal damage and outcome in subarachnoid hemorrhage. J Neurol Neurosurg Psychiatry 77: 753-759.
10. Lewis SB, Wolper RA, Miralia L, Yang C, Shaw G, (2008) Detection of phosphorylated NF-H in the cerebrospinal fluid and blood of aneurysmal subarachnoid hemorrhage patients. J Cereb Blood Flow Metab 28: 1261-1271.
11. Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, et al. (2007) Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg 107: 792-796.
12. Lewis SB, Wolper R, Chi Y-Y, Miralia L, Wang Y, et al. (2010) Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage. J Neurosci Res 88: 1475-1484.
13. Lad SP, Hegen H, Gupta G, Deisenhammer F, Steinberg GK, (2011) Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage. J Stroke Cerebrovasc Dis (in press).
14. Siman R, McIntosh TK, Soltesz KM, Chen Z, Neumar RW, Roberts VL, (2004) Proteins released from degenerating neurons are surrogate markers for acute brain damage in the rat. Neurobiol. Dis 16: 311-320.
15. Siman R, Zhang C, Roberts VL, Pitts-Kiefer A, Neumar RW, (2005) Novel surrogate markers for acute brain damage: cerebrospinal fluid levels correlate with severity of ischemic neurodegeneration in the rat. J Cereb Blood Flow Metab 25: 1433-1444.
16. Siman R, Roberts VL, McNeil E, Dang A, Bavaria JE, et al. (2008) Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. Brain Res 1213: 1-11.
17. Siman R, Toraskar N, Dang A, McNeil E, McGarvey M, et al. (2009) A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma 26: 1867-1877.
18. Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, et al. (2007) Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma 24: 354-366.
19. Liu MC, Akinyi L, Scharf D, Mo J, Larner SF, et al. (2010) Ubiquitin C-terminal hydrolase L1 as a biomarker for ischemic and traumatic brain injury in rats. Eur J Neurosci 31: 722-732.
20. Siman R, Noszek JC, Kegerise C, (1989) Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 9: 1579-1590.
21. Roberts-Lewis JM, Siman R, (1993) Spectrin proteolysis in the hippocampus: a biochemical marker for neuronal injury and neuroprotection. Ann NY Acad Sci 679: 78-86.
22. Roberts-Lewis JM, Savage MJ, Marcy V, Pinsker L, Siman R, (1994) Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J Neurosci 16: 3934-3944.
23. Zhang C, Siman R, Xu YA, Mills AM, Frederick JR, Neumar RW, (2002) Comparison of calpain and caspase activities in the adult rat brain after transient forebrain ischemia. Neurobiol Dis 10: 289-305.
24. Pike BR, Flint J, Dave JR, Lu XC, Wang KK, et al. (2004) Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived alphaII-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 24: 98-106.
25. Chen HI, Stiefel MF, Oddo M, Milby AH, Maloney-Wilensky E, et al. (2011) Detection of cerebral compromise with multimodality monitoring in patients with subarachnoid hemorrhage. Neurosurgery 69: 53-63.
26. Smith ML, Abrahams JM, Chandela S, Smith MJ, Hurst RW, et al. (2005) Subarachnoid hemorrhage on computed tomography scanning and the development of cerebral vasospasm: the Fisher grade revisited. Surg Neurol 63: 229-235.
27. Siman R, Noszek JC, (1988) Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron 1: 279-287.
28. Wang KKW, (2000) Calpain and caspase: can you tell the difference? Trends Neurosci 23: 20-26.
29. Jonsson H, Johnsson P, Hoglund P, Alling C, Blomquist S, (2000) Elimination of S100B and renal function after cardiac surgery. J Cardiothorac Vasc Anesth 14: 698-701.
30. Shirao S, Yoneda H, Kunitsugu I, Ishihara H, Koizumi H, et al. (2010) Preoperative prediction of outcome in 283 poor-grade patients with subarachnoid hemorrhage: a project of the Chugoku-Shikoku Division of the Japan Neurosurgical Society. Cerebrovasc Dis 30: 105-113.
31. Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, et al. (2006) Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified Fisher scale. Neurosurgery 59: 21-27.
32. Hoh BL, Topcuoglu MA, Singhal AB, Pryor JC, Rabinov JD, et al. (2004) Effect of clipping, craniotomy, or intravascular coiling on cerebral vasospasm and patient outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery 55: 779-786.
33. Sehba FA, Pluta RM, Zhang JH, (2011) Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol 43: 27-40.
34. Yamashima T, (2004) Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium 36: 285-293.
35. Petzold A, (2005) Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration, and loss. J Neurol Sci 233: 183-198.