Fluorine-18 labeled thia fatty acids for PET imaging of fatty acid oxidation in heart and cancer

Heart and Metabolism

Volumn , Issue 51, 2011, Pages 15-19

  Pandey, Mukesh K ^a   Bansal, Aditya ^a   DeGrado, Timothy R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Fatty acid oxidation; FTHA; FTO; FTP; PET; Thia fatty acid

Indexed keywords

14 [18F]FLUORO 6 THIA HEPTADECANOIC ACID; 16 [18F]FLUORO 4 THIA PALMITATE; 18 [18F]FLUORO 4 THIA OLEATE; FATTY ACID DERIVATIVE; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ARTICLE; CANCER CELL CULTURE; CARDIOMYOPATHY; FATTY ACID OXIDATION; GLUCOSE TRANSPORT; HEART FAILURE; HUMAN; ISCHEMIC HEART DISEASE; MYOCARDITIS; NONHUMAN; PATIENT MONITORING; PHOSPHORYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 82955246758     PISSN: 15660338     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Poeppel TD, Krause BJ, Heusner TA, Boy C, Bockisch A, Antoch G (2009) PET/CT for the staging and follow-up of patients with malignancies. Eur J Radiol 70:382-392
2. Knuuti J, Tuunanen H (2010) Metabolic imaging in myocardial ischemia and heart failure. Q J Nucl Med Mol Imaging 54:168-176
3. Shoghi KI, Finck BN, Schechtman KB, Sharp T, Herrero P, Gropler RJ, Welch MJ (2009) In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy. Circ Cardiovasc Imaging 2(5):373-381
4. Schelbert HR, Schwaiger M (1986) PET studies of the heart. In: Phelps M, Mazziotta JC, Schelbert HR. eds. Positron emission tomography and autoradiography. Principles and applications for the brain and heart. New York: Raven Press, p. 581-661
5. Fox KAA, Abendschein DR, Ambos HD, Sobel BE, Bergman SR (1985) Effects of metabolized and nonmetabolized fatty acid from canine myocardium: implications for quantifying myocardial metabolism tomographically. Cire Res 57:232-243 (Pubitemid 15247779)
6. Rosamond TL Abendschein DR. Sobel BE, Bergmann SR. Fox KAA (1987) Metabolic fate of radiolabeled palmitate in ischemic canine myocardium: implications for positron emission tomography. J Nucl Med 28:1322-1329 (Pubitemid 17156421)
7. Wyns W, Schwaiger M, Huang SC, Buxton DB, Hansen H, Selin C, Keen R, Phelps ME, Schelbert HR (1989) Effects of inhibition of fatty acid oxidation on myocardial kinetics of C-labeled palmitate. Circ Res 65:1787-1797 (Pubitemid 20023570)
8. 18F] fluoro-6-thiaheptadecanoic acid (FTHA). Journal of Labeled Compounds and Radiopharmaceuticals 29:989-995
9. 18F]fluoro- 6-thia-heptadecanoic acid (FTHA): evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids. J Nucl Med 32:1888-1896
10. Ebert A, Herzog H, Stain GL, Henrich MM, DeGrado TR, Coenen HH, Feinendegen LE (1994) Kinetics of 14(R, S)-fluorine-18-fluoro-6-thia- heptadecanoic acid in normal human hearts at rest, during exercise and after dipyridamole injection. J Nucl Med 35:51-56 (Pubitemid 24018440)
11. Renstrom B, Rommelfanger S, Stone CK, DeGrado TR, Carlson KJ, Scarbrough E, Nickles RJ, Liedtke AJ, Holden JE (1998) Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. J Nucl Med 39:1684-1689 (Pubitemid 28473513)
12. 18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle. Eur J Nucl Med Mol Imaging 29:1617-1622
13. Wallhaus TR, Taylor M, DeGrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK (2001) Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure. Circulation 103:2441-2446 (Pubitemid 32493369)
14. 18F]FDG in patients with congestive heart failure. J Nucl Med 42:55-62
15. Turpeinen AK, Takala TO, Nuutila P, Axelin T, Luotolahti M, Haaparanta M, Bergman J, Hämäläinen H, Iida H, Mäki M, Uusitupa MI, Knuuti J (1999) Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid. Diabetes 48:1245-1250 (Pubitemid 29241021)
16. 18F]fluoro-6-thia-heptadecanoic acid and PET. Eur J Nucl Med Mol Imaging 30:1160-1164
17. Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Någren K, Solin O, Nuutila P (2010) Increased brain fatty acid uptake in metabolic syndrome. Diabetes 59:2171-2177
18. DeGrado TR, Wang S, Holden JE, Nickles RJ, Taylor M, Stone CK (2000) Synthesis and preliminary evaluation of (18)F-labeled 4-thia palmitate as a PET tracer of myocardial fatty acid oxidation. Nucl Med Biol 27:221-231 (Pubitemid 30314715)
19. 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids. J Nucl Med 47:173-181
20. 18F-fluoro- 4-thia-oleic Acid (FTO) as a PET probe of fatty acid oxidation. J Nucl Med 51:1310-1317
21. DeLany JP, Windhauser MM, Champagne CM, Bray GA (2000) Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 72:905-911
22. Lopaschuk GD, Ussher JR, Folmes CDL, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90:207-258
23. Liu Y (2006) Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis 9:230-234
24. 18F]fluoro-4-thia-palmitate (FTP) uptake in hypoxic 9L glioma cells. J Nucl Med 51(Suppl 1):198P
25. Kubota K, Takahashi T, Fujiwara T, Yamada S, Sato T, Kubota R, Iwata R, Ishiwata K, Ido T, Matsuzawa T (1991) Possibility for tumor detection with fatty acid analogs. Int J Rad Appl Instrum B 18:191-195
26. Greig NH, Nariai T, Noronha JG, Schmall B, Larson DM, Soncrant TT, Rapoport SI (1991) Brain tumor imaging in rats using the positron emitting fatty acid dl-erythro-9,10-[18F] difluoropalmitate. Clin Exp Metastasis 9:67-73