Simulated Red Blood Cell Motion in Microvessel Bifurcations: Effects of Cell-Cell Interactions on Cell Partitioning

Cardiovascular Engineering and Technology

Volumn 2, Issue 4, 2011, Pages 349-360

  Barber, Jared O ^a   Restrepo, Juan M ^b   Secomb, Timothy W ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Bifurcation; Capillary flow; Erythrocyte mechanics; Microvessel; Phase separation

Indexed keywords

CELL PARTITIONING; CELL-CELL INTERACTION; COMBINED EFFECT; EXPERIMENTAL OBSERVATION; LOW REYNOLDS NUMBER FLOW; MECHANICAL INTERACTIONS; MICROVESSEL; RED BLOOD CELL; TWO DIMENSIONAL MODEL; VISCOELASTIC ELEMENTS;

BIFURCATION (MATHEMATICS); BLOOD; BLOOD VESSELS; CAPILLARY FLOW; CYTOLOGY; PHASE SEPARATION; REYNOLDS NUMBER;

CELLS;

ARTICLE; BLOOD FLOW; CELL INTERACTION; CELL MIGRATION; CELL MOTION; CELL SEPARATION; CYTOPLASM; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE KINETICS; ERYTHROCYTE MEMBRANE; FINITE ELEMENT ANALYSIS; FOLLOWING CELL INTERACTION; HEMATOCRIT; HERDING CELL INTERACTION; MICROVASCULATURE; MICROVESSEL BIFURCATION; PRIORITY JOURNAL; SIMULATION; TRADE OFF CELL INTERACTION; VISCOELASTICITY;

EID: 82955246358     PISSN: 1869408X     EISSN: 18694098     Source Type: Journal    
DOI: 10.1007/s13239-011-0064-4     Document Type: Article

References (25)

1. Audet, D. M., and W. L. Olbricht. The motion of model cells at capillary bifurcations. Microvasc. Res. 33: 377-396, 1987.
2. Barber, J. O. Computational Simulation of Red Blood Cell Motion in Microvascular Flows. Dissertation, The University of Arizona, Tucson (AZ), 2009.
3. Barber, J. O., J. P. Alberding, J. M. Restrepo, and T. W. Secomb. Simulated two-dimensional red blood cell motion, deformation, and partitioning in microvessel bifurcations. Ann. Biomed. Eng. 36: 1690-1698, 2008.
4. Carr, R. T., J. B. Geddes, and F. Wu. Oscillations in a simple microvascular network. Ann. Biomed. Eng. 33: 764-771, 2005.
5. Carr, R. T., and L. L. Wickham. Influence of vessel diameter on red-cell distribution at microvascular bifurcations. Microvasc. Res. 41: 184-196, 1991.
6. Chesnutt, J. K., and J. S. Marshall. Effect of particle collisions and aggregation on red blood cell passage through a bifurcation. Microvasc. Res. 78: 301-313, 2009.
7. Dellimore, J. W., M. J. Dunlop, and P. B. Canham. Ratio of cells and plasma in blood flowing past branches in small plastic channels. Am. J. Physiol. 244: H635-H643, 1983.
8. Dewhirst, M. W., H. Kimura, S. W. Rehmus, R. D. Braun, D. Papahadjopoulus, K. Hong, and T. W. Secomb. Microvascular studies on the origins of perfusion-limited hypoxia. Br. J. Cancer Suppl. 27: S247-S251, 1996.
9. Ditchfield, R., and W. L. Olbricht. Effects of particle concentration on the partitioning of suspensions at small divergent bifurcations. J. Biomech. Eng. 118: 287-294, 1996.
10. El-Kareh, A. W., and T. W. Secomb. A model for red blood cell motion in bifurcating microvessels. Int. J. Multiph. Flow. 26: 1545-1564, 2000.
11. Ellsworth, M. L. Red blood cell-derived ATP as a regulator of skeletal muscle perfusion. Med. Sci. Sports Exerc. 36: 35-41, 2004.
12. Enden, G., and A. S. Popel. A numerical study of the shape of the surface separating flow into branches in microvascular bifurcations. J. Biomech. Eng. 114: 398-405, 1992.
13. Enden, G., and A. S. Popel. A numerical study of plasma skimming in small vascular bifurcations. J. Biomech. Eng. 116: 79-88, 1994.
14. Fenton, B. M., R. T. Carr, and G. R. Cokelet. Nonuniform red cell distribution in 20 to 100 micrometers bifurcations. Microvasc. Res. 29: 103-126, 1985.
15. Gaehtgens, P., C. Duhrssen, and K. H. Albrecht. Motion, deformation, and interaction of blood-cells and plasma during flow through narrow capillary tubes. Blood Cells. 6: 799-812, 1980.
16. Leal, L. G. Particle motions in a viscous-fluid. Annu. Rev. Fluid Mech. 12: 435-476, 1980.
17. Pries, A. R., K. Ley, M. Claassen, and P. Gaehtgens. Red cell distribution at microvascular bifurcations. Microvasc. Res. 38: 81-101, 1989.
18. Pries, A. R., K. Ley, and P. Gaehtgens. Generalization of the Fahraeus principle for microvessel networks. Am. J. Physiol. 251: H1324-H1332, 1986.
19. Pries, A. R., and T. W. Secomb. Microvascular blood viscosity in vivo and the endothelial surface layer. Am. J. Physiol. Heart Circ. Physiol. 289: H2657-H2664, 2005.
20. Pries, A. R., T. W. Secomb, and P. Gaehtgens. Biophysical aspects of blood flow in the microvasculature. Cardiovasc. Res. 32: 654-667, 1996.
21. Pries, A. R., T. W. Secomb, and P. Gaehtgens. The endothelial surface layer. Pflugers Arch. 440: 653-666, 2000.
22. Reglin, B., T. W. Secomb, and A. R. Pries. Structural adaptation of microvessel diameters in response to metabolic stimuli: where are the oxygen sensors? Am. J. Physiol. Heart Circ. Physiol. 29: H2206-H2219, 2009.
23. Schmid-Schonbein, G. W., R. Skalak, S. Usami, and S. Chien. Cell distribution in capillary networks. Microvasc. Res. 19: 18-44, 1980.
24. Secomb, T. W., A. R. Pries, and P. Gaehtgens. Hematocrit fluctuations within capillary tubes and estimation of Fahraeus effect. Int. J. Microcirc. Clin. Exp. 5: 335-345, 1987.
25. Secomb, T. W., B. Styp-Rekowska, and A. R. Pries. Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels. Ann. Biomed. Eng. 35: 755-765, 2007.