Simultaneous determination of tectorigenin, irigenin and irisflorentin in rat plasma and urine by UHPLC-MS/MS: Application to pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 31, 2011, Pages 3735-3741

  Zhang, Wei dong ^a   Yang, Wan jun ^a   Wang, Xiao juan ^a   Gu, Yi ^a   Wang, Rong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Excretion; Pharmacokinetic; Quantitative analysis; Rhizoma Belamcandae; UHPLC ESI MS MS

Indexed keywords

ACTIVE COMPONENTS; AGILENT; ANALYTES; CALIBRATION CURVES; CHROMATOGRAPHIC SEPARATIONS; EXCRETION; GRADIENT ELUTION; IONIZATION MODES; ISOFLAVONES; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; POLARITY SWITCHING; RAT PLASMA; RHIZOMA BELAMCANDAE; SAMPLE STORAGE; SIMULTANEOUS DETERMINATIONS; UHPLC-ESI-MS/MS;

ACETONITRILE; CHEMICAL ANALYSIS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; PHARMACOKINETICS; RATS;

BODY FLUIDS;

FLAVONOID; IRIGENIN; IRISFLORENTIN; PLANT EXTRACT; RHIZOMA BELAMCANDAE EXTRACT; TECTORIGENIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; DRUG BLOOD LEVEL; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; IRIS; ISOFLAVONES; LIMIT OF DETECTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 82955241455     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.10.022     Document Type: Article

References (15)

1. Chinese Pharmacopoeia Commission Chinese Pharmacopoeia 2005, vol. I. Chemical and Industrial Publisher, p. 200. 2005 ed.
2. Seidlova-Wuttke D., Hesse O., Jarry H., Rimoldi G., Thelen P., Christoffel V., Wuttke W. Phytomedicine 2004, 11:392.
3. Thelen P., Scharf J.G., Burfeind P., Hemmerlein B., Wuttke W., Spengler B., Christoffel V., Ringert R.H., Seidlov-Wuttke D. Carcinogenesis 2005, 26:360.
4. Morrissey C., Bektic J., Spengler B., Galvin D., Christoffel V., Klocker H., Fitzpatrick M., Watson W. J. Urol. 2004, 172:2426.
5. Ahn K.S., Noh E.J., Cha K., Kim Y.S., Lim S.S., Shin K.H., Jung S.H. Life Sci. 2006, 78:2336.
6. Li J., Li W.Z., Huang W., Cheung A.W., Bi C.W., Duan R., Guo A.J., Dong T.T., Tsim K.W. J. Chromatogr. A 2009, 1216:2071.
7. Bae E.A., Han M.J., Lee K.T., Choi J.W., Park H.J. Biol. Pharm. Bull. 1999, 22:1314.
8. Thelen P., Seseke F.R., Ringert H., Wuttke W., Seidlova-Wuttke D. Urologe A 2006, 45:195.
9. Thelen P., Scharf J.G., Burfeind P., Hemmerlein B., Wuttke W., Spengler B. Carcinogenesis 2005, 26:1360.
10. Jung H.S., Lee Y.S., Lee S., Lim S.S., Kim Y.S., Shin K.H. Arch. Pharm. Res. 2002, 25:306.
11. Shin J.E., Bae E.A., Lee Y.C., Ma J.Y., Kim D.H. Biol. Pharm. Bull. 2006, 29:1202.
12. Zhang W.D., Qi L.W., Yang X.L., Lu Y.W., Li P., Yang Z.L. Chromatographia 2008, 68:1021.
13. Qin M.J., Ji W.L., Wang Z.T. China J. Chin. Mater. Med. 2006, 31:1681.
14. Liu X.H., Pan J.H., Wang Y.X. Chin. Tradit. Herb. Drugs 2000, 31:739.
15. USFDA, 2001. http://www.fda.gov/downloads/Drugs/Guidance%20Compliance%20Regulatory%20Information/Guidances/ucm070107.pdf.