Nonencapsulated or nontypeable Haemophilus influenzae are more likely than their encapsulated or serotypeable counterparts to have mutations in their fucose operon

Canadian Journal of Microbiology

Volumn 57, Issue 12, 2011, Pages 982-986

  Shuel, Michelle L ^a   Karlowsky, Kathleen E ^a   Law, Dennis K S ^a   Tsang, Raymond S W ^a  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

Fucose operon; Haemophilus influenzae; Mutation; Nonencapsulated

Indexed keywords

DNA SEQUENCING; FUCOSE OPERON; HAEMOPHILUS INFLUENZAE; HOUSEKEEPING GENE; MULTILOCUS SEQUENCE TYPING; MUTATION; NONENCAPSULATED; NONTYPEABLE HAEMOPHILUS INFLUENZAE; NUCLEOTIDE SEQUENCES;

BIOTECHNOLOGY; MICROBIOLOGY;

GENE ENCODING;

FUCOSE; PROTEIN FUCK; UNCLASSIFIED DRUG;

BACTERIUM; INFLUENZA; MICROBIAL ECOLOGY; MUTATION;

ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CONTROLLED STUDY; DNA SEQUENCE; GENE DELETION; GENE MUTATION; HAEMOPHILUS INFLUENZAE; MULTILOCUS SEQUENCE TYPING; NONHUMAN; OPERON; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROTYPE;

ALLELES; BACTERIAL CAPSULES; FUCOSE; HAEMOPHILUS INFLUENZAE; MOLECULAR SEQUENCE DATA; MUTATION; OPERON; SEQUENCE ANALYSIS, DNA; SEROTYPING;

EID: 82955235634     PISSN: 00084166     EISSN: 14803275     Source Type: Journal    
DOI: 10.1139/W11-017     Document Type: Article

References (15)

1. Falla, T.J., Crook, D.W., Brophy, L.N., Maskell, D., Kroll, J.S., and Moxon, E.R. 1994. PCR for capsule typing of Haemophilus influenzae. J. Clin. Microbiol. 32(10): 2382-2386.
2. Fleischmann, R.D., Adams, M.D., White, O., Clayton, R.A., Kirkness, E.F., Kerlavage, A.R., et al. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science, 269(5223): 496-512. doi:10.1126/science.7542800.
3. Fung, W.W.M., O'Dwyer, C.A., Sinha, S., Brauer, A.L., Murphy, T. F., Kroll, J.S., and Langford, P.R. 2006. Presence of copper- and zinc-containing superoxide dismutase in commensal Haemophilus haemolyticus isolates can be used as a marker to dicriminate them from nontypeable H. influenzae isolates. J. Clin. Microbiol. 44(11): 4222-4226. doi:10.1128/JCM.01376-06.
4. Hogg, J.S., Hu, F.Z., Janto, B., Boissy, R., Hayes, J., Keefe, R., et al. 2007. Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains. Genome Biol. 8(6): R103-R120. doi:10.1186/gb-2007-8-6-r103.
5. Kilian, M. 2007. Haemophilus. Manual of clinical microbiology. 9th ed. Vol. 1. Edited by P.R. Murray, E. Jo Baron, J.H. Jorgensen, M.E. Landry, and M.A. Pfaller. ASM Press, Washington, D.C. pp. 638-648.
6. Ladhani, S., Slack, M.P.E., Heath, P.T., von Gottberg, A., Chandra, M., and Ramsay, R.E. European Union Invasive Bacterial Infection Surveillance participants. 2010. Invasive Haemophilus influenzae disease, Europe, 1996-2006. Emerg. Infect. Dis. 16(3): 455-463. doi:10.3201/eid1603.090290.
7. Langford, P.R., Sheehan, B.J., Shaikh, T., and Kroll, J.S. 2002. Active copper- and zinc-containing superoxide dismutase in the cryptic genospecies of Haemophilus causing urogenital and neonatal infections discriminates them from Haemophilus influenzae sensu stricto. J. Clin. Microbiol. 40(1): 268-270. doi:10.1128/JCM.40.1.268-270.2002.
8. Lau, S.K., Woo, P.C., Mok, M., Teng, J.L., Tam, V.K., Chan, K.K., and Yuen, K.Y. 2004. Characterization of Haemophilus segnis, an important cause of bacteremia, by 16S rRNA gene sequencing. J. Clin. Microbiol. 42(2): 877-880. doi:10.1128/JCM.42.2.877-880.2004.
9. Macfadyen, L.P., and Redfield, R.J. 1996. Life in mucus: sugar metabolism in Haemophilus influenzae. Res. Microbiol. 147(6-7): 541-551. doi:10.1016/0923-2508(96)84010-1.
10. Macfadyen, L.P., Dorocicz, I.R., Reizer, J., Saier, M.H., Jr, and Redfield, R.J. 1996. Regulation of competency development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate: fructose phosphotransferase system. Mol. Microbiol. 21(5): 941-952. doi:10.1046/j.1365-2958.1996.441420.x.
11. Meats, E., Feil, E.J., Stringer, S., Cody, A.J., Goldstein, R., Kroll, J.S., et al. 2003. Characterization of encapsulated and non-encapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing. J. Clin. Microbiol. 41(4): 1623-1636. doi:10.1128/JCM.41.4.1623-1636.2003.
12. Nørskov-Lauritsen, N. 2009. Detection of cryptic genospecies misidentified as Haemophilus influenzae in routine clinical samples by assessment of marker genes, fucK, hap and sodC. J. Clin. Microbiol. 47(8): 2590-2592. doi:10.1128/JCM.00013-09.
13. Pittman, M. 1931. Variations and type specificity in the bacterialspecies Haemophilus influenzae. J. Exp. Med. 53(4): 471-492. doi:10.1084/jem.53.4.471.
14. Postma, P.W., Lengeler, J.W., and Jacobson, G.R. 1993. Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteria. Microbiol. Rev. 57(3): 543-594.
15. Ridderberg, W., Fenger, M.G., and Nørskov-Lauritsen, N. 2010. Haemophilus influenzae may be untypeable by the multilocus sequence typing scheme die to a complete deletion of the fucose operon. J. Med. Microbiol. 59(6): 740-742. doi:10.1099/jmm.0.018424-0.