Effect of d-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: A randomized controlled trial

Psychopharmacology

Volumn 218, Issue 3, 2011, Pages 589-597

  Kuriyama, Kenichi ^a   Honma, Motoyasu ^a   Soshi, Takahiro ^a   Fujii, Takeshi ^a   Kim, Yoshiharu ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

d Cycloserine; Fear conditioning; Memory extinction; Reinstatement; Skin conductance; Valproic acid

Indexed keywords

CYCLOSERINE; PLACEBO; VALPROIC ACID;

ADULT; ANXIETY DISORDER; ARTICLE; COGNITIVE THERAPY; COLLEGE STUDENT; CONDITIONING; CONTROLLED STUDY; DROWSINESS; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG POTENTIATION; ELECTRIC SHOCK; FACILITATION; FEAR; FEMALE; HABITUATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR DISORDER; RANDOMIZED CONTROLLED TRIAL; RECALL; REINFORCEMENT; SINGLE DRUG DOSE; SKIN CONDUCTANCE; STIMULUS RESPONSE; VISUAL STIMULATION;

ADULT; CONDITIONING (PSYCHOLOGY); CUES; CYCLOSERINE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ELECTROSHOCK; EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; HUMANS; MALE; MEMORY; RECEPTORS, N-METHYL-D-ASPARTATE; VALPROIC ACID; YOUNG ADULT;

EID: 82955233566     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2353-x     Document Type: Article

References (50)

1. E Acquas C Wilson HC Fibiger 1996 Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: effects of novelty, habituation, and fear J Neurosci 16 3089 3096 8622138 1:CAS:528:DyaK28XisFSks7k%3D (Pubitemid 26121851)
2. E Baldi CA Lorenzini C Bucherelli 2004 Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat Neurobiol Learn Mem 81 162 166 15082017 10.1016/j.nlm.2004.02.004 (Pubitemid 38479656)
3. TW Bredy M Barad 2008 The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear Learn Mem 15 39 45 18174372 10.1101/lm.801108 1:CAS:528:DC%2BD1cXotFGgu7Y%3D (Pubitemid 351171604)
4. TW Bredy H Wu C Crego J Zellhoefer YE Sun M Barad 2007 Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear Learn Mem 14 268 276 17522015 10.1101/lm.500907 1:CAS:528:DC%2BD1cXms1Orurs%3D (Pubitemid 46625629)
5. C Castellano V Cestari A Ciamei 2001 NMDA receptors and learning and memory processes Curr Drug Targets 2 273 283 11554552 10.2174/1389450013348515 1:CAS:528:DC%2BD3MXntVGlurs%3D (Pubitemid 32821470)
6. JP Chhatwal L Stanek-Rattiner M Davis KJ Ressler 2006 Amygdala BDNF signaling is required for consolidation but not encoding of extinction Nat Neurosci 9 870 872 16783370 10.1038/nn1718 1:CAS:528:DC%2BD28XmtFCmsbs%3D (Pubitemid 43980497)
7. M Corsi-Cabrera C Arce J Ramos I Lorenzo MA Guevara 1996 Time course of reaction time and EEG while performing a vigilance task during total sleep deprivation Sleep 19 563 569 8899935 1:STN:280:DyaK2s%2FlsFKnug%3D%3D (Pubitemid 26339701)
8. M Davis K Ressler BO Rothbaum R Richardson 2006 Effects of d-cycloserine on extinction: translation from preclinical to clinical work Biol Psychiatry 60 369 375 16919524 10.1016/j.biopsych.2006.03.084 1:CAS:528:DC%2BD28XotlKnu7w%3D (Pubitemid 44215855)
9. M Effting M Kindt 2007 Contextual control of human fear associations in a renewal paradigm Behav Res Ther 45 2002 2018 17451643 10.1016/j.brat.2007.02. 011 (Pubitemid 47210949)
10. M Göttlicher 2004 Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases Ann Hematol 83 S91 92 15124690
11. C Grillon 2009 D-cycloserine facilitation of fear extinction and exposure-based therapy might rely on lower-level, automatic mechanisms Biol Psychiatry 66 636 641 19520359 10.1016/j.biopsych.2009.04.017 1:CAS:528:DC%2BD1MXhtFWqtLfP
12. AJ Guastella MR Dadds PF Lovibond P Mitchell R Richardson 2007 A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear J Psychiatr Res 41 466 471 16828803 10.1016/j.jpsychires.2006. 05.006 (Pubitemid 46227445)
13. AJ Guastella PF Lovibond MR Dadds P Mitchell R Richardson 2007 A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans Behav Res Ther 45 663 672 16962066 10.1016/j.brat.2006.07.005 (Pubitemid 46282625)
14. AJ Guastella R Richardson PF Lovibond RM Rapee JE Gaston P Mitchell, et al. 2008 A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder Biol Psychiatry 63 544 549 18179785 10.1016/j.biopsych.2007.11.011 1:CAS:528:DC%2BD1cXitlGrsbg%3D
15. SG Hofmann 2008 Cognitive processes during fear acquisition and extinction in animals and humans: implications for exposure therapy of anxiety disorders Clin Psychol Rev 28 199 210 17532105 10.1016/j.cpr.2007.04.009 (Pubitemid 351172540)
16. SG Hofmann AE Meuret JA Smits NM Simon MH Pollack K Eisenmenger, et al. 2006 Augmentation of exposure therapy with D-cycloserine for social anxiety disorder Arch Gen Psychiatry 63 298 304 16520435 10.1001/archpsyc.63.3.298 1:CAS:528:DC%2BD28XislGis7k%3D (Pubitemid 43345354)
17. GS Jeon SH Park KJ Lee MS Lee BG Chun KH Shin 2006 Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain Eur J Pharmacol 545 142 146 16884712 10.1016/j.ejphar.2006.06.046 1:CAS:528:DC%2BD28XovVSktLY%3D
18. R Kalisch B Holt P Petrovic B De Martino S Klöppel C Büchel RJ Dolan 2009 The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans Cereb Cortex 19 187 196 18477687 10.1093/cercor/bhn076
19. BS Kapp RC Frysinger M Gallagher J Haselton 1979 Amygdala central nucleus lesions: effect on heart rate conditioning in the rabbit Physiol Behav 23 1109 1117 542522 10.1016/0031-9384(79)90304-4 1:STN:280:DyaL3c7mslGgtw%3D%3D (Pubitemid 10104552)
20. E Kempf G Mack C Schleef P Mandel 1982 Effect of valproic acid on brain serotonin metabolism in isolated and grouped rats Pharmacol Biochem Behav 17 49 52 6812096 10.1016/0091-3057(82)90261-1 1:CAS:528:DyaL38XkvVGht74%3D (Pubitemid 12040737)
21. U Klotz KH Antonin 1977 Pharmacokinetics and bioavailability of sodium valproate Clin Pharmacol Ther 21 736 43 324695 1:CAS:528:DyaE2sXks1artrw%3D (Pubitemid 8131717)
22. K Kuriyama M Honma S Koyama Y Kim 2011 D-cycloserine facilitates procedural learning but not declarative learning in healthy humans: a randomized controlled trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks Neurobiol Learn Mem 95 505 509 21402164 10.1016/j.nlm.2011.02.017 1:CAS:528:DC%2BC3MXlsFKjsrw%3D
23. MG Kushner SW Kim C Donahue P Thuras D Adson M Kotlyar, et al. 2007 D-cycloserine augmented exposure therapy for obsessive-compulsive disorder Biol Psychiatry 62 835 838 17588545 10.1016/j.biopsych.2006.12.020 1:CAS:528:DC%2BD2sXhtFerur%2FO (Pubitemid 47488217)
24. OM Larsson L Gram I Schousboe A Schousboe 1986 Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes Neuropharmacology 25 617 625 3092125 10.1016/0028-3908(86)90214-5 1:CAS:528:DyaL28Xlt1yjtrc%3D (Pubitemid 16056526)
25. L Ledgerwood R Richardson J Cranney 2003 Effects of D-cycloserine on extinction of conditioned freezing Behav Neurosci 117 341 349 12708530 10.1037/0735-7044.117.2.341 1:CAS:528:DC%2BD3sXivFehtrc%3D (Pubitemid 36384252)
26. L Ledgerwood R Richardson J Cranney 2004 D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement Behav Neurosci 118 505 513 15174928 10.1037/0735-7044.118.3.505 (Pubitemid 38685318)
27. JL Lee AL Milton BJ Everitt 2006 Reconsolidation and extinction of conditioned fear: inhibition and potentiation J Neurosci 26 10051 10056 17005868 10.1523/JNEUROSCI.2466-06.2006 1:CAS:528:DC%2BD28XhtVOmtLbE (Pubitemid 44477166)
28. F Li JZ Tsien 2009 Memory and the NMDA receptors N Engl J Med 361 302 303 19605837 10.1056/NEJMcibr0902052 1:CAS:528:DC%2BD1MXos1Wrtro%3D
29. I Lorenzo J Ramos C Arce MA Guevara M Corsi-Cabrera 1995 Effect of total sleep deprivation on reaction time and waking EEG activity in man Sleep 18 346 354 7676168 1:STN:280:DyaK2Mvgs1KjsQ%3D%3D
30. SE Maxwell JC Cameron RD Arvey 1981 Measures of strength of association: a comparative examination J Appl Psychol 66 525 534 10.1037/0021-9010.66.5.525
31. J Moses A Lubin P Naitoh LC Johnson 1978 Circadian variation in performance, subjective sleepiness, sleep, and oral temperature during an altered sleep-wake schedule Biol Psychol 6 301 308 708814 10.1016/0301-0511(78) 90032-7 1:STN:280:DyaE1M%2Fkt1emsw%3D%3D (Pubitemid 9032200)
32. KGS Neir IG Epstein H Baron MG Mulinos 1956 Absorption, distribution and excretion of cycloserine in man Antibiot Annu 3 136 140
33. JW Newcomer JH Krystal 2001 NMDA receptor regulation of memory and behavior in human Hippocampus 11 529 542 11732706 10.1002/hipo.1069 1:CAS:528:DC%2BD3MXptVKrs7k%3D (Pubitemid 33100374)
34. MM Norberg JH Krystal DF Tolin 2008 A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy Biol Psychiatry 63 1118 1126 18313643 10.1016/j.biopsych.2008.01.012 1:CAS:528:DC%2BD1cXmsFOjt7c%3D
35. OA Onur TE Schlaepfer J Kukolja A Bauer H Jeung A Patin, et al. 2010 The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans Biol Psychiatry 67 1205 1211 20303474 10.1016/j.biopsych.2010.01.022 1:CAS:528:DC%2BC3cXntVGiu78%3D
36. SP Orr LJ Metzger NB Lasko ML Macklin T Peri RK Pitman 2000 De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder J Abnorm Psychol 109 290 298 10895567 10.1037/0021-843X.109.2.290 1:STN:280:DC%2BD3czoslertw%3D%3D (Pubitemid 30616926)
37. MW Otto DF Tolin NM Simon GD Pearlson S Basden SA Meunier, et al. 2010 Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder Biol Psychiatry 67 365 370 19811776 10.1016/j.biopsych.2009. 07.036 1:CAS:528:DC%2BC3cXhtl2hsbo%3D
38. LC Ou PW Gean 2006 Regulation of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol-3-kinase Neuropsychopharmacology 31 287 296 16034442 10.1038/sj.npp.1300830 1:CAS:528:DC%2BD28XkvFylsg%3D%3D (Pubitemid 43113394)
39. LM Rattiner M Davis KJ Ressler 2004 Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning Learn Mem 11 727 731 15537738 10.1101/lm.83304 (Pubitemid 39602512)
40. KJ Ressler BO Rothbaum L Tannenbaum P Anderson K Graap E Zimand, et al. 2004 Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear Arch Gen Psychiatry 61 1136 1144 15520361 10.1001/archpsyc.61.11.1136 (Pubitemid 39463415)
41. M Rezvanfard MR Zarrindast P Bina 2009 Role of ventral hippocampal GABA(A) and NMDA receptors in the anxiolytic effect of carbamazepine in rats using the elevated plus maze test Pharmacology 84 356 366 19907194 10.1159/000256666 1:CAS:528:DC%2BD1MXhsFaqt7nK
42. EA Storch LJ Melro M Bengtson TK Murphy MH Lewis MC Yang, et al. 2007 D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder Int Clin Psychopharmacol 22 230 237 17519647 10.1097/YIC.0b013e32819f8480 (Pubitemid 46801947)
43. EA Storch TK Murphy WK Goodman GR Geffken AB Lewin A Henin, et al. 2010 A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder Biol Psychiatry 68 1073 1076 20817153 10.1016/j.biopsych.2010.07.015 1:CAS:528:DC%2BC3cXhsVWqtLnI
44. R Veit H Flor M Erb C Hermann M Lotze W Grodd, et al. 2002 Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans Neurosci Lett 328 233 236 12147314 10.1016/S0304-3940(02)00519-0 1:CAS:528:DC%2BD38XlvVWisb0%3D (Pubitemid 34876654)
45. DL Walker KJ Ressler KT Lu M Davis 2002 Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats J Neurosci 22 2343 2351 11896173 1:CAS:528:DC%2BD38XisVGit7g%3D (Pubitemid 35386533)
46. BJ Wilder RJ Rangel 1988 Review of valproate monotherapy in the treatment of generalized tonic-clonic seizures Am J Med 84 7 13 3146225 10.1016/0002-9343(88)90050-2 1:STN:280:DyaL1M7hs1WksQ%3D%3D
47. S Wilhelm U Buhlmann DF Tolin SA Meunier GD Pearlson HE Reese, et al. 2008 Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder Am J Psychiatry 165 335 341 18245177 10.1176/appi.ajp.2007.07050776 (Pubitemid 351704489)
48. AM Woods ME Bouton 2006 D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response Behav Neurosci 120 1159 1162 17014266 10.1037/0735-7044.120.5.1159 1:CAS:528:DC%2BD28XhtFyhsrnL (Pubitemid 44584025)
49. IT Yu JY Park SH Kim JS Lee YS Kim H Son 2009 Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation Neuropharmacology 56 473 480 19007798 10.1016/j.neuropharm.2008. 09.019 1:CAS:528:DC%2BD1MXhtVGju7w%3D
50. SH Zeisel 2008 Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models Brain Res 1237 5 11 18789905 10.1016/j.brainres.2008.08.059 1:CAS:528:DC%2BD1cXht1SisLjO