Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: Application to a bioequivalence study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 32, 2011, Pages 3937-3942

  Hu, Ziyan ^a   Zou, Qiaogen ^b   Tian, Jixin ^a   Sun, Lili ^a   Zhang, Zunjian ^a,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING TECH UNIVERSITY   (China)

^c China Pharmaceutical University   (China)

Author keywords

Bioequivalence; Chlorpheniramine; Codeine; Ephedrine; Guaiphenesin; HPLC MS MS

Indexed keywords

BIOEQUIVALENCE; CHLORPHENIRAMINE; CODEINE; EPHEDRINE; GUAIPHENESIN; HPLC-MS/MS;

AMMONIUM COMPOUNDS; BIOLOGICAL MEMBRANES; CHROMATOGRAPHY; DRUG PRODUCTS; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; SOLVENT EXTRACTION;

LIQUIDS;

AMMONIUM ACETATE; CHLORPHENIRAMINE; CODEINE; EPHEDRINE; FORMIC ACID; GUAIFENESIN; METHANOL;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DOG; FLOW RATE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHLORPHENIRAMINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CODEINE; DOGS; EPHEDRINE; GUAIFENESIN; LEAST-SQUARES ANALYSIS; LIMIT OF DETECTION; LIQUID-LIQUID EXTRACTION; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY;

CANIS FAMILIARIS;

EID: 82955213023     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.11.001     Document Type: Article

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