Determinants of intracranial hemorrhage incidence in patients on oral anticoagulation followed at the Lahey clinic

Journal of Thrombosis and Thrombolysis

Volumn 32, Issue 3, 2011, Pages 334-342

  Mantha, Simon ^a,b   Pianka, Ann Marie ^a   Tsapatsaris, Nicholas ^a,b  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anticoagulation; Blood pressure; INR; Intracranial hemorrhage

Indexed keywords

ACETYLSALICYLIC ACID; CREATININE; HEMOGLOBIN; THIENOPYRIDINE DERIVATIVE; WARFARIN;

AGE; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRAIN HEMORRHAGE; CASE CONTROL STUDY; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG INDICATION; DRUG USE; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; MALE; MEAN ARTERIAL PRESSURE; PATIENT IDENTIFICATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SEX DIFFERENCE;

AGE FACTORS; AGED; ANTICOAGULANTS; ASPIRIN; BLOOD PRESSURE; CASE-CONTROL STUDIES; DATABASES, FACTUAL; FEMALE; HUMANS; INCIDENCE; INTERNATIONAL NORMALIZED RATIO; INTRACRANIAL HEMORRHAGES; MALE; MODELS, CARDIOVASCULAR; PLATELET AGGREGATION INHIBITORS; PYRIDINES; RISK; SEX FACTORS; WARFARIN;

EID: 82955213014     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-011-0609-2     Document Type: Article

References (32)

1. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G (2008) Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133(6 Suppl): 160S-198S. doi:10.1378/chest.08-0670 (Pubitemid 351892967)
2. Fang MC, Go AS, Chang Y, Hylek EM, Henault LE, Jensvold NG, Singer DE (2007) Death and disability from warfarinassociated intracranial and extracranial hemorrhages. Am J Med 120(8):700-705. doi:10.1016/j.amjmed.2006.07. 034 (Pubitemid 47176507)
3. Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM (2004) The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med 164(8): 880-884. doi:10.1001/archinte.164.8.880 (Pubitemid 38520629)
4. Singer DE, Chang Y, Fang MC, Borowsky LH, Pomernacki NK, Udaltsova N, Go AS (2009) Should patient characteristics influence target anticoagulation intensity for stroke prevention in nonvalvular atrial fibrillation?: The ATRIA study. Circ Cardiovasc Qual Outcomes 2(4):297-304. doi:10.1161/CIRCOUTCOMES. 108.830232
5. Fang MC, Chang Y, Hylek EM, Rosand J, Greenberg SM, Go AS, Singer DE (2004) Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation. Ann Intern Med 141(10):745-752
6. Fang MC, Go AS, Hylek EM, Chang Y, Henault LE, Jensvold NG, Singer DE (2006) Age and the risk of warfarin-associated hemorrhage: the anticoagulation and risk factors in atrial fibrillation study. J Am Geriatr Soc 54(8):1231-1236. doi:10.1111/j. 1532-5415.2006.00828.x (Pubitemid 44166528)
7. Berwaerts J, Webster J (2000) Analysis of risk factors involved in oral-anticoagulant-related intracranial haemorrhages. QJM 93(8): 513-521 (Pubitemid 30623787)
8. A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin. The stroke prevention in reversible ischemia trial (SPIRIT) study group (1997). Ann Neurol 42(6):857-865. doi:10.1002/ana.410420606 (Pubitemid 28008415)
9. Hart RG, Tonarelli SB, Pearce LA (2005) Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas. Stroke 36(7):1588-1593. doi:10.1161/01.STR.0000 170642.39876.f2 (Pubitemid 40967537)
10. Hart RG, Benavente O, Pearce LA (1999) Increased risk of intracranial hemorrhage when aspirin is combined with warfarin: a meta-analysis and hypothesis. Cerebrovasc Dis 9(4):215-217 (Pubitemid 29308806)
11. Ariesen MJ, Claus SP, Rinkel GJ, Algra A (2003) Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke 34(8):2060-2065. doi:10.1161/01.STR.00000806 78.09344.8D01.STR.0000080678.09344. 8D (Pubitemid 36944806)
12. Leppala JM, Virtamo J, Fogelholm R, Albanes D, Heinonen OP (1999) Different risk factors for different stroke subtypes: association of blood pressure, cholesterol, and antioxidants. Stroke 30(12):2535-2540
13. Suh I, Jee SH, Kim HC, Nam CM, Kim IS, Appel LJ (2001) Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study. Lancet 357(9260):922-925. doi:10.1016/S0140-6736(00)04213-6 (Pubitemid 32247281)
14. Landefeld CS, Goldman L (1989) Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy. Am J Med 87(2):144-152 (Pubitemid 19201634)
15. Beyth RJ, Quinn LM, Landefeld CS (1998) Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med 105(2):91-99 (Pubitemid 28405230)
16. Kuijer PM, Hutten BA, Prins MH, Buller HR (1999) Prediction of the risk of bleeding during anticoagulant treatment for venous thromboembolism. Arch Intern Med 159(5):457-460 (Pubitemid 29108910)
17. Wells PS, Forgie MA, Simms M, Greene A, Touchie D, Lewis G, Anderson J, Rodger MA (2003) The outpatient bleeding risk index: validation of a tool for predicting bleeding rates in patients treated for deep venous thrombosis and pulmonary embolism. Arch Intern Med 163(8):917-920 (Pubitemid 36519737)
18. Aspinall SL, DeSanzo BE, LE Trilli, Good CB (2005) Bleeding risk index in an anticoagulation clinic. Assessment by indication and implications for care. J Gen Intern Med 20(11):1008-1013 (Pubitemid 41726654)
19. Shireman TI, Mahnken JD, Howard PA, Kresowik TF, Hou Q, Ellerbeck EF (2006) Development of a contemporary bleeding risk model for elderly warfarin recipients. Chest 130(5):1390-1396 (Pubitemid 44786731)
20. Gage BF, Yan Y, Milligan PE, Waterman AD, Culverhouse R, Rich MW, Radford MJ (2006) Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J 151(3):713-719 (Pubitemid 43290267)
21. Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, Rosand J (2009) Anemia and hematoma volume in acute intracerebral hemorrhage. Crit Care Med 37(4):1442-1447. doi:10.1097/CCM.0b013e31819ced3a
22. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6, 105 individuals with previous stroke or transient ischaemic attack (2001). Lancet 358(9287):1033-1041. doi: 10.1016/S0140-6736(01)06178-5 (Pubitemid 32925123)
23. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials (1994). Arch Intern Med 154(13):1449-1457
24. Singer DE, Chang Y, Fang MC, Borowsky LH, Pomernacki NK, Udaltsova N, Go AS (2009) The net clinical benefit of warfarin anticoagulation in atrial fibrillation. Ann Intern Med 151(5):297-305
25. Radziwon P, Boczkowska-Radziwon B, Schenk JF, Wojtukiewicz MZ, Kloczko J, Giedrojc J, Breddin HK (1999) Platelet-induced thrombin generation time II (PITT II). A modified global coagulation test to monitor prophylactic anticoagulation with vitamin K antagonists? Thromb Res 96(1):77-81 (Pubitemid 29502227)
26. Hemker HC, Beguin S (1985) The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. Verh K Acad Geneeskd Belg 47(5):321-339
27. Hemker HC, Wielders S, Kessels H, Beguin S (1993) Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. Thromb Haemost 70(4):617-624 (Pubitemid 23310567)
28. Hemker HC (2008) Recollections on thrombin generation. J Thromb Haemost 6(2):219-226. doi:10.1111/j.1538-7836.2007. 02864.x
29. Altman R, Scazziota A, Herrera L, Gonzalez C (2007) Relationship between thrombin generation and international normalized ratio in patients receiving oral vitamin K antagonist therapy. J Thromb Haemost 5(7):1552-1569
30. Brocal I, Marco P, Lucas J, Verdu J, Tarin F (2009) Thrombin generation test in patients under anticoagulant therapy with vitamin K antagonists. Thromb Haemost 101(3):594-595
31. Livio M, Gotti E, Marchesi D, Mecca G, Remuzzi G, de Gaetano G (1982) Uraemic bleeding: role of anaemia and beneficial effect of red cell transfusions. Lancet 2(8306):1013-1015 (Pubitemid 12035188)
32. Fernandez F, Goudable C, Sie P, Ton-That H, Durand D, Suc JM, Boneu B (1985) Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusions. Br J Haematol 59(1):139-148 (Pubitemid 15188829)