Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity

Xenobiotica

Volumn 42, Issue 1, 2012, Pages 86-93

  Jones, Rhys M ^a   Neef, Natasha ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Foamy macrophage; Lung burden; Particulate accumulation; Risk assessment

Indexed keywords

RESPIRATORY TRACT AGENT; TITANIUM DIOXIDE;

DRUG ACCUMULATION; HISTOPATHOLOGY; HUMAN; LUNG ALVEOLUS MACROPHAGE; LUNG BURDEN; LUNG TOXICITY; LUNG WEIGHT; NONHUMAN; REVIEW; RISK FACTOR; STEADY STATE; SYSTEMIC CIRCULATION;

ADMINISTRATION, INHALATION; ANIMALS; BIOSTATISTICS; CLINICAL TRIALS AS TOPIC; DRUG TOXICITY; HUMANS; LUNG; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PARTICLE SIZE; PARTICULATE MATTER; PHARMACEUTICAL PREPARATIONS; RATS; RISK ASSESSMENT; TITANIUM;

EID: 82955205864     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.632827     Document Type: Review

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