Dendrimer-based fluorescent indicators: In vitro and in vivo applications

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Albertazzi, Lorenzo ^a,b   Brondi, Marco ^a,b   Pavan, Giovanni M ^c   Sato, Sebastian Sulis ^a,b   Signore, Giovanni ^b   Storti, Barbara ^a,b   Ratto, Gian Michele ^a   Beltram, Fabio ^a,b  

^a SCUOLA NORMALE SUPERIORE   (Italy)

^b CENTER FOR NANOTECHNOLOGY INNOVATION NEST   (Italy)

^c UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN; DENDRIMER; FLUORESCENT DYE; MACROGOL; POLYAMIDOAMINE; TETRAMETHYLRHODAMINE; ORGANIC COMPOUND;

ANIMAL CELL; ARTICLE; BRAIN REGION; CHEMICAL STRUCTURE; CHO CELL; CONTROLLED STUDY; DISEASE MODEL; EPILEPSY; FLUORESCENCE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; ANIMAL; BRAIN; CHEMISTRY; COMPUTER SIMULATION; CRICETULUS; FLUORESCENCE MICROSCOPY; GENETIC PROCEDURES; HAMSTER; METABOLISM; METHODOLOGY; MICROSCOPY; NANOTECHNOLOGY;

ANIMALS; BIOSENSING TECHNIQUES; BRAIN; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; DENDRIMERS; DISEASE MODELS, ANIMAL; EPILEPSY; FLUORESCENT DYES; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICROSCOPY; MICROSCOPY, FLUORESCENCE; NANOTECHNOLOGY; ORGANIC CHEMICALS;

EID: 82955201705     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028450     Document Type: Article

References (31)

1. Giepmans BN, Adams SR, Ellisman MH, Tsien RY, (2006) The fluorescent toolbox for assessing protein location and function. Science 312: 217-224.
2. Lakowicz JR, (2006) Principles of fluorescence spectroscopy New York Springer.
3. Zhang J, Campbell RE, Ting AY, Tsien RY, (2002) Creating new fluorescent probes for cell biology. Nat Rev Mol Cell Biol 3: 906-918.
4. Grynkiewicz G, Poenie M, Tsien RY, (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450.
5. Buccella D, Horowitz JA, Lippard SJ, (2011) Understanding zinc quantification with existing and advanced ditopic fluorescent Zinpyr sensors. J Am Chem Soc 133 (11): 4101-14.
6. Kojima H, Urano Y, Kikuchi K, Higuchi T, Hirata Y, et al. (1999) Fluorescent Indicators for Imaging Nitric Oxide Production. Angew Chem Int Ed Engl 38: 3209-3212.
7. Lecoq J, Parpaleix A, Roussakis E, Ducros M, Houssen YG, et al. (2011) Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels. Nat Med 17 (7): 893-8.
8. Signore G, Nifosi R, Albertazzi L, Storti B, Bizzarri R, (2010) Polarity-sensitive coumarins tailored to live cell imaging. J Am Chem Soc 132: 1276-1288.
9. Grinvald A, Hildesheim R, (2004) VSDI: a new era in functional imaging of cortical dynamics. Nat Rev Neurosci 5: 874-885.
10. Mizukami S, Watanabe S, Kikuchi K, (2009) Development of ratiometric fluorescent probes for phosphatases by using a pK(a) switching mechanism. Chembiochem 10: 1465-1468.
11. Karton-Lifshin N, Segal E, Omer L, Portnoy M, Satchi-Fainaro R, et al. (2011) A unique paradigm for Turn-ON near-infrared cyanine-based probe: noninvasive intravital optical imaging of hydrogen peroxide. J Am Chem Soc 133 (28): 10960-5.
12. Lee CC, MacKay JA, Frechet JM, Szoka FC, (2005) Designing dendrimers for biological applications. Nat Biotechnol 23: 1517-1526.
13. Astruc D, Boisselier E, Ornelas C, (2010) Dendrimers designed for functions: from physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine. Chem Rev 110: 1857-1959.
14. Albertazzi L, Storti B, Marchetti L, Beltram F, (2010) Delivery and subcellular targeting of dendrimer-based fluorescent pH sensors in living cells. J Am Chem Soc 132: 18158-18167.
15. Sakadzic S, Roussakis E, Yaseen M, Mandeville ET, Srinivasan VJ, et al. (2010) Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods 7: 755-759.
16. Wang X, Boschetti C, Ruedas-Rama MJ, Tunnacliffe A, Hall EA, (2010) Ratiometric pH-dot ANSors. Analyst 135: 1585-1591.
17. Wangler C, Moldenhauer G, Saffrich R, Knapp EM, Beijer B, et al. (2008) PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules. Chemistry 14: 8116-8130.
18. Szmacinski H, Lakowicz JR, (1993) Optical measurements of pH using fluorescence lifetimes and phase-modulation fluorometry. Anal Chem 65: 168-74.
19. Painter RG, Wang G, (2006) Direct measurement of free chloride concentrations in the phagolysosomes of human neutrophils. Anal Chem 78: 3133-3137.
20. Meuwis K, Boens N, De Schryver FC, Gallay J, Vincent M, (1995) Photophysics of the fluorecent K+ indicator PBFI. Biophys J 68: 2469-73.
21. Silver RA, Whitaker M, Bolsover SR, (1992) Intracellular ion imaging using fluorescent dyes: artefacts and limits to resolution. Pflugers Arch 420: 595-602.
22. Hillman EM, (2007) Optical brain imaging in vivo: techniques and applications from animal to man. J Biomed Opt 12: 051402.
23. Dityatev A, Schachner M, Sonderegger P, (2010) The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat Rev Neurosci 11: 735-746.
24. Feng ZC, Sick TJ, Rosenthal M, (1990) Extracellular pH and suppression of electrical activity during anoxia in turtle and rat brain. Am J Physiol 258: R205-210.
25. Huppert TJ, Jones PB, Devor A, Dunn AK, Teng IC, et al. (2009) Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia. J Biomed Opt 14: 044038.
26. Avoli M, Biagini G, de Curtis M, (2006) Do interictal spikes sustain seizures and epileptogenesis? Epilepsy Curr 6: 203-207.
27. Ziemann AE, Schnizler NK, Albert GW, Severson MA, Howard MA, et al. (2008) Seizure termination by acidosis depends on ASIC1a. Nat Neurosci 11: 816-822.
28. Case DAD, Cheatham TE III, Simmerling CL, Wang J, Duke RE, et al. (2010) AMBER 11. University of California, San Francisco (2010).
29. Pavan GM, Kostiainen MA, Danani A, (2010) Computational approach for understanding the interactions of UV-degradable dendrons with DNA and siRNA. J Phys Chem B 114: 5686-5693.
30. Pavan GM, Albertazzi L, Danani A, (2010) Ability to adapt: different generations of PAMAM dendrimers show different behaviors in binding siRNA. J Phys Chem B 114: 2667-2675.
31. Pavan GM, Mintzer MA, Simanek EE, Merkel OM, Kissel T, et al. (2010) Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers. Biomacromolecules 11: 721-730.