Effects of antiglaucoma drugs on the ocular surface in rabbits: A fixed-combination drug versus two concomitant drugs

Japanese Journal of Ophthalmology

Volumn 55, Issue 6, 2011, Pages 670-675

  Cho, Hyun Kyung ^a   Park, Myoung Hee ^a   Moon, Jung Il ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Adverse ocular surface change; Benzalkonium chloride; Fixed combination antiglaucoma drug; Multiple antiglaucoma drugs

Indexed keywords

RYSMON TG; TIMOLOL; TIMOLOL PLUS TRAVOPROST; TRAVOPROST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; EPITHELIUM CELL; EXPERIMENTAL RABBIT; EYE BIOPSY; EYE EXAMINATION; GOBLET CELL; MALE; MONOTHERAPY; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; SURFACE PROPERTY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CLOPROSTENOL; CONJUNCTIVA; CORNEA; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; EPITHELIAL CELLS; MALE; RABBITS; TIMOLOL;

EID: 82955188756     PISSN: 00215155     EISSN: 16132246     Source Type: Journal    
DOI: 10.1007/s10384-011-0078-3     Document Type: Article

References (24)

1. PP Chen 2003 Blindness in patients with treated open-angle glaucoma Ophthalmology 110 726 733 12689894 10.1016/S0161-6420(02)01974-7 (Pubitemid 36520071)
2. MG Hattenhauer DH Johnson HH Ing DC Herman DO Hodge BP Yawn, et al. 1998 The probability of blindness from open-angle glaucoma Ophthalmology 105 2099 2104 9818612 10.1016/S0161-6420(98)91133-2 1:STN:280:DyaK1M%2Fjtl2hsw%3D%3D (Pubitemid 30211780)
3. Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:701-13 (discussion 829-30). (Pubitemid 34620348)
4. E Turaçli K Budak A Kaur B Mizrak C Ekinci 1997 The effects of long-term topical glaucoma medication on conjunctival impression cytology Int Ophthalmol 21 27 33 9298420 10.1023/A:1005892426045 (Pubitemid 27382075)
5. MK Arici DS Arici A Topalkara C Güler 2000 Adverse effects of topical antiglaucoma drugs on the ocular surface Clin Exp Ophthalmol 28 113 117 10.1046/j.1442-9071.2000.00237.x 1:STN:280:DC%2BD3M%2FjtlymtQ%3D%3D (Pubitemid 30458440)
6. C Costagliola AD Prete C Incorvaia R Fusco F Parmeggiani A Di Giovanni 2001 Ocular surface changes induced by topical application of latanoprost and timolol: a short-term study in glaucomatous patients with and without allergic conjunctivitis Graefes Arch Clin Exp Ophthalmol 239 809 814 11789860 10.1007/s004170100328 1:CAS:528:DC%2BD38XntFeqtA%3D%3D (Pubitemid 33114932)
7. C Baudouin P Hamard H Liang C Creuzot-Garcher L Bensoussan F Brignole 2004 Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term Ophthalmology 111 2186 2192 15582072 10.1016/j.ophtha.2004.06.023 (Pubitemid 39575587)
8. JM Herreras JC Pastor M Calonge VM Asensio 1992 Ocular surface alteration after long-term treatment with an antiglaucomatous drug Ophthalmology 99 1082 1088 1495787 1:STN:280:DyaK38zlslCgtQ%3D%3D
9. R Singh A Joseph T Umapathy NL Tint HS Dua 2005 Impression cytology of the ocular surface Br J Ophthalmol 89 1655 1659 16299150 10.1136/bjo.2005.073916 1:STN:280:DC%2BD2Mnhs1aruw%3D%3D (Pubitemid 41729915)
10. JD Nelson VR Havener JD Cameron 1983 Cellulose acetate impressions of the ocular surface. Dry eye states Arch Ophthalmol 101 1869 1972 6651590 10.1001/archopht.1983.01040020871007 1:STN:280:DyaL2c%2FnvFWnug%3D%3D
11. D Broadway I Grierson R Hitchings 1993 Adverse effects of topical antiglaucomatous medications on the conjunctiva Br J Ophthalmol 77 590 596 8218059 10.1136/bjo.77.9.590 1:STN:280:DyaK2c%2Fjt1SrtQ%3D%3D (Pubitemid 23281461)
12. DC Broadway I Grierson C O'Brien RA Hitchings 1994 Adverse effects of topical antiglaucoma medication. II. The outcome of filtration surgery Arch Ophthalmol 112 1446 1454 7980134 10.1001/archopht.1994.01090230060021 1:STN:280:DyaK2M%2FntV2nsQ%3D%3D (Pubitemid 24350507)
13. MJ Lavin RP Wormald CS Migdal RA Hitchings 1990 The influence of prior therapy on the success of trabeculectomy Arch Ophthalmol 108 1543 1548 2244836 10.1001/archopht.1990.01070130045027 1:STN:280:DyaK3M%2FlvVCnsw%3D%3D (Pubitemid 20377540)
14. CU Richter BJ Shingleton AR Bellows BT Hutchinson T O'Connor I Brill 1988 The development of encapsulated filtering blebs Ophthalmology 95 1163 1168 2905439 1:STN:280:DyaL1M%2Fpsl2isg%3D%3D
15. S Hong CS Lee KY Seo GJ Seong YJ Hong 2006 Effects of topical antiglaucoma application on conjunctival impression cytology specimens Am J Ophthalmol 142 185 186 16815281 10.1016/j.ajo.2006.02.056 1:CAS:528: DC%2BD28Xms1GktbY%3D (Pubitemid 43946804)
16. PJ Pisella K Fillacier PP Elena C Debbasch C Baudouin 2000 Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits Ophthalmic Res 32 3 8 10657748 10.1159/000055579 1:CAS:528:DC%2BD3cXhvFersbk%3D (Pubitemid 30093503)
17. IR Schwab JV Linberg VM Gioia WH Benson GM Chao 1992 Foreshortening of the inferior conjunctival fornix associated with chronic glaucoma medications Ophthalmology 99 197 202 1348114 1:STN:280:DyaK383gsVKhsg%3D%3D
18. H Ichijima WM Petroll JV Jester HD Cavanagh 1992 Confocal microscopic studies of living rabbit cornea treated with benzalkonium chloride Cornea 11 221 225 1587129 1:STN:280:DyaK383ms1Olsg%3D%3D
19. RR Pfister N Burstein 1976 The effects of ophthalmic drugs, vehicles, and preservatives on corneal epithelium: a scanning electron microscope study Invest Ophthalmol 15 246 259 1262158 1:STN:280:DyaE287ms12qtA%3D%3D
20. C Baudouin PJ Pisella K Fillacier M Goldschild F Becquet M De Saint Jean, et al. 1999 Ocular surface inflammatory changes induced by topical antiglaucoma drugs Ophthalmology 106 556 563 10080214 10.1016/S0161-6420(99)90116-1 1:STN:280:DyaK1M7nvVaquw%3D%3D (Pubitemid 30191592)
21. BJ Tripathi RC Tripathi SP Kolli 1992 Cytotoxicity of ophthalmic preservatives on human corneal epithelium Lens Eye Toxic Res 9 361 375 1301792 1:CAS:528:DyaK3sXkt1SntL8%3D (Pubitemid 23111708)
22. NL Burstein 1980 Corneal cytotoxicity of topically applied drugs, vehicles and preservatives Surv Ophthalmol 25 15 30 6998034 10.1016/0039- 6257(80)90072-7 1:CAS:528:DyaL3cXlsVant7o%3D (Pubitemid 10087456)
23. Kim JR, Oh TH, Kim HS. Effect of benzalkonium chloride on the ocular surface in the rabbit. Jpn J Ophthalmol. 2010 (Accepted for publication).
24. J Thygesen K Aaen F Theodorsen SV Kessing JU Prause 2000 Short-term effect of latanoprost and timolol eye drops on tear fluid and the ocular surface in patients with primary open-angle glaucoma and ocular hypertension Acta Ophthalmol Scand 78 37 44 10726786 10.1034/j.1600-0420.2000.078001037.x 1:CAS:528:DC%2BD3cXhsF2ltrc%3D (Pubitemid 30095308)