Arachidonic acid- and prostaglandin E 2-induced cerebral vasodilation is mediated by carbon monoxide, independent of reactive oxygen species in piglets

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 6, 2011, Pages 2482-2487

  Kanu, Alie ^a   Leffler, Charles W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Cyclooxygenase; Eicosanoids; Heme oxygenase; Neonatal; Oxygen radicals; Pial arterioles

Indexed keywords

ARACHIDONIC ACID; CARBON MONOXIDE; CATALASE; CHROMIUM MESOPORPHYRIN; HEME DERIVATIVE; HEME LEVO LYSINATE; HEME OXYGENASE INHIBITOR; HYPOXANTHINE; ILOPROST; INDOMETACIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; TEMPOL; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; CEREBRAL VASODILATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; NEWBORN; NONHUMAN; PIGLET; PRIORITY JOURNAL; VASODILATATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; ARACHIDONIC ACID; ARTERIOLES; CARBON MONOXIDE; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); PIA MATER; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SWINE; VASODILATION; VASODILATOR AGENTS; XANTHINE OXIDASE;

EID: 82855169270     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00628.2011     Document Type: Article

References (37)

1. Armstead WM, Mirro R, Busija DW, Desiderio DM, Leffler CW. Opioids in cerebrospinal fluid in hypotensive newborn pigs. Circ Res 68: 922-929, 1991.
2. Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, Snyder SH. Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron 40: 129-137, 2003.
3. Caccese D, Pratico D, Ghiselli A, Natoli S, Pignatelli P, Sanguigni V, Iuliano L, Violi F. Superoxide anion and hydroxyl radical release by collagen-induced platelet aggregation-role of arachidonic acid metabolism. Thromb Haemost 83: 485-490, 2000.
4. Didion SP, Hathaway CA, Faraci FM. Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. Am J Physiol Heart Circ Physiol 281: H1697-H1703, 2001.
5. Holt DC, Fedinec AL, Vaughn AN, Leffler CW. Age and species dependence of pial arteriolar responses to topical carbon monoxide in vivo. Exp Biol Med (Maywood) 232: 1465-1469, 2007.
6. Hsu P, Shibata M, Leffler CW. Prostanoid synthesis in response to high CO2 in newborn pig brain microvascular endothelial cells. Am J Physiol Heart Circ Physiol 264: H1485-H1492, 1993.
7. Jakovcevic D, Harder DR. Role of astrocytes in matching blood flow to neuronal activity. Curr Top Dev Biol 79: 75-97, 2007.
8. Johnson FK, Johnson RA. Carbon monoxide promotes endotheliumdependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol 285: R536-R541, 2003.
9. Kanu A, Gilpin D, Fedinec AL, Leffler CW. Cyclooxygenase products stimulate carbon monoxide production by piglet cerebral microvessels. Exp Biol Med (Maywood) 231: 181-185, 2006.
10. Kanu A, Leffler CW. Roles of glia limitans astrocytes and carbon monoxide in adenosine diphosphate-induced pial arteriolar dilation in newborn pigs. Stroke 40: 930-935, 2009.
11. Kanu A, Whitfield J, Leffler CW. Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets. Am J Physiol Heart Circ Physiol 291: H2409-H2414, 2006.
12. Katsuura G, Gottschall PE, Dahl RR, Arimura A. Interleukin-1 beta increases prostaglandin E2 in rat astrocyte cultures: modulatory effect of neuropeptides. Endocrinology 124: 3125-3127, 1989.
13. Knecht KR, Milam S, Wilkinson DA, Fedinec AL, Leffler CW. Time-dependent action of carbon monoxide on the newborn cerebrovascular circulation. Am J Physiol Heart Circ Physiol 299: H70-H75, 2010.
14. Kontos HA. Oxygen radicals from arachidonate metabolism in abnormal vascular responses. Am Rev Respir Dis 136: 474-477, 1987.
15. Leffler CW, Balabanova L. Mechanism of permissive prostacyclin action in cerebrovascular smooth muscle. Prostaglandins Other Lipid Mediat 66: 145-153, 2001.
16. Leffler CW, Balabanova L, Fedinec AL, Parfenova H. Nitric oxide increases carbon monoxide production by piglet cerebral microvessels. Am J Physiol Heart Circ Physiol 289: H1442-H1447, 2005.
17. Leffler CW, Busija DW. Arachidonic acid metabolites and perinatal cerebral hemodynamics. Semin Perinatol 11: 31-42, 1987.
18. Leffler CW, Busija DW. Prostanoids and pial arteriolar diameter in hypotensive newborn pigs. Am J Physiol Heart Circ Physiol 252: H687-H691, 1987.
19. Leffler CW, Parfenova H, Jaggar JH, Wang R. Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation. J Appl Physiol 100: 1065-1076, 2006.
20. Leffler CW, Smith JS, Edrington JL, Zuckerman SL, Parfenova H. Mechanisms of hypoxia-induced cerebrovascular dilation in the newborn pig. Am J Physiol Heart Circ Physiol 272: H1323-H1332, 1997.
21. Li A, Xi Q, Umstot ES, Bellner L, Schwartzman ML, Jaggar JH, Leffler CW. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels. Circ Res 102: 234-241, 2008.
22. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554, 1997.
23. Parfenova H, Balabanova L, Leffler CW. Posttranslational regulation of cyclooxygenase by tyrosine phosphorylation in cerebral endothelial cells. Am J Physiol Cell Physiol 274: C72-C81, 1998.
24. Parfenova H, Eidson TH, Leffler CW. Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals. Am J Physiol Cell Physiol 273: C277-C288, 1997.
25. Parfenova H, Leffler CW. Effects of hypercapnia on prostanoid and cAMP production by cerebral microvascular cell cultures. Am J Physiol Cell Physiol 270: C1503-C1510, 1996.
26. Parfenova H, Leffler CW. Functional study on vasodilator effects of prostaglandin E2 in the newborn pig cerebral circulation. Eur J Pharmacol 278: 133-142, 1995.
27. Parfenova H, Levine V, Gunther WM, Pourcyrous M, Leffler CW. COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells. Pediatr Res 52: 342-348, 2002.
28. Parfenova H, Shibata M, Zuckerman S, Leffler CW. CO2 and cerebral circulation in newborn pigs: cyclic nucleotides and prostanoids in vascular regulation. Am J Physiol Heart Circ Physiol 266: H1494-H1501, 1994.
29. Pederson T. Thinking about a nuclear matrix. J Mol Biol 277: 147-159, 1998.
30. Schreiber J, Eling TE, Mason RP. The oxidation of arachidonic acid by the cyclooxygenase activity of purified prostaglandin H synthase: spin trapping of a carbon-centered free radical intermediate. Arch Biochem Biophys 249: 126-136, 1986.
31. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69: 145-182, 2000.
32. Smith WL, Marnett LJ, DeWitt DL. Prostaglandin and thromboxane biosynthesis. Pharmacol Ther 49: 153-179, 1991.
33. Tamayo-Orrego L, Duque-Parra JE. [The metabolic regulation of cerebral microcirculation]. Rev Neurol 44: 415-425, 2007.
34. Tenhunen R, Tokola O, Linden IB. Haem arginate: a new stable haem compound. J Pharm Pharmacol 39: 780-786, 1987.
35. Tsubokura S, Watanabe Y, Ehara H, Imamura K, Sugimoto O, Kagamiyama H, Yamamoto S, Hayaishi O. Localization of prostaglandin endoperoxide synthase in neurons and glia in monkey brain. Brain Res 543: 15-24, 1991.
36. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11: 371-386, 1993.
37. Zonta M, Sebelin A, Gobbo S, Fellin T, Pozzan T, Carmignoto G. Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J Physiol 553: 407-414, 2003.