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Volumn 96, Issue 12, 2011, Pages 1815-1821

Minimal residual disease in peripheral blood at day 15 identifies a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with superior prognosis

Author keywords

Acute lymphoblastic leukemia; Childhood; Day 15; Minimal residual disease; Peripheral blood

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BLOOD EXAMINATION; BONE MARROW EXAMINATION; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FOLLOW UP; HEPATOMEGALY; HUMAN; HUMAN TISSUE; LEUKEMIA RELAPSE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MINIMAL RESIDUAL DISEASE; PRE B LYMPHOCYTE; PREDICTION; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SPLENOMEGALY;

EID: 82855168105     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.042937     Document Type: Article
Times cited : (21)

References (37)
  • 1
    • 0032572924 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group
    • Cave H, van der Werff ten Bosch J, Suciu S, Guidal C, Waterkeyn C, Otten J, et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group. N Engl J Med. 1998;339(9):591-8.
    • (1998) N Engl J Med , vol.339 , Issue.9 , pp. 591-598
    • Cave, H.1    van der Werff ten Bosch, J.2    Suciu, S.3    Guidal, C.4    Waterkeyn, C.5    Otten, J.6
  • 2
    • 0034667685 scopus 로고    scopus 로고
    • Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia
    • Coustan Smith E, Sancho J, Hancock ML, Boyett JM, Behm FG, Raimondi SC, et al. Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia. Blood. 2000;96(8):2691-6.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2691-2696
    • Coustan, S.E.1    Sancho, J.2    Hancock, M.L.3    Boyett, J.M.4    Behm, F.G.5    Raimondi, S.C.6
  • 4
    • 42349085052 scopus 로고    scopus 로고
    • Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia
    • Flohr T, Schrauder A, Cazzaniga G, Panzer-Grumayer R, van der Velden V, Fischer S, et al. Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia. Leukemia. 2008;22(4):771-82.
    • (2008) Leukemia , vol.22 , Issue.4 , pp. 771-782
    • Flohr, T.1    Schrauder, A.2    Cazzaniga, G.3    Panzer-Grumayer, R.4    van der Velden, V.5    Fischer, S.6
  • 5
    • 3042622767 scopus 로고    scopus 로고
    • Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia
    • Pui CH, Relling MV, Sandlund JT, Downing JR, Campana D, Evans WE. Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. Ann Hematol. 2004;83 (Suppl 1):S124-6.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Pui, C.H.1    Relling, M.V.2    Sandlund, J.T.3    Downing, J.R.4    Campana, D.5    Evans, W.E.6
  • 6
    • 33846892770 scopus 로고    scopus 로고
    • Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: A combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG)
    • Schultz KR, Pullen DJ, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, et al. Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG). Blood. 2007;109(3):926-35.
    • (2007) Blood , vol.109 , Issue.3 , pp. 926-935
    • Schultz, K.R.1    Pullen, D.J.2    Sather, H.N.3    Shuster, J.J.4    Devidas, M.5    Borowitz, M.J.6
  • 7
    • 34548817262 scopus 로고    scopus 로고
    • Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01
    • Zhou J, Goldwasser MA, Li A, Dahlberg SE, Neuberg D, Wang H, et al. Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01. Blood. 2007; 110(5):1607-11.
    • (2007) Blood , vol.110 , Issue.5 , pp. 1607-1611
    • Zhou, J.1    Goldwasser, M.A.2    Li, A.3    Dahlberg, S.E.4    Neuberg, D.5    Wang, H.6
  • 8
    • 77951441599 scopus 로고    scopus 로고
    • Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: Results in 3184 patients of the AIEOP-BFM ALL 2000 study
    • Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grumayer R, Moricke A, et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood. 2010;115(16):3206-14.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3206-3214
    • Conter, V.1    Bartram, C.R.2    Valsecchi, M.G.3    Schrauder, A.4    Panzer-Grumayer, R.5    Moricke, A.6
  • 9
    • 0030663383 scopus 로고    scopus 로고
    • Monitoring minimal residual disease in peripheral blood in B-lineage acute lymphoblastic leukaemia
    • Brisco MJ, Sykes PJ, Hughes E, Dolman G, Neoh SH, Peng LM, et al. Monitoring minimal residual disease in peripheral blood in B-lineage acute lymphoblastic leukaemia. Br J Haematol. 1997;99(2):314-9.
    • (1997) Br J Haematol , vol.99 , Issue.2 , pp. 314-319
    • Brisco, M.J.1    Sykes, P.J.2    Hughes, E.3    Dolman, G.4    Neoh, S.H.5    Peng, L.M.6
  • 10
    • 0036786910 scopus 로고    scopus 로고
    • Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia
    • Coustan-Smith E, Sancho J, Hancock ML, Razzouk BI, Ribeiro RC, Rivera GK, et al. Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. Blood. 2002;100(7):2399-402.
    • (2002) Blood , vol.100 , Issue.7 , pp. 2399-2402
    • Coustan-Smith, E.1    Sancho, J.2    Hancock, M.L.3    Razzouk, B.I.4    Ribeiro, R.C.5    Rivera, G.K.6
  • 11
    • 0028219670 scopus 로고
    • In patients with BCR-ABL-positive ALL in CR peripheral blood contains less residual disease than bone marrow: Implications for autologous BMT
    • Martin H, Atta J, Bruecher J, Elsner S, Schardt C, Stadler M, et al. In patients with BCR-ABL-positive ALL in CR peripheral blood contains less residual disease than bone marrow: implications for autologous BMT. Ann Hematol. 1994;68(2):85-7.
    • (1994) Ann Hematol , vol.68 , Issue.2 , pp. 85-87
    • Martin, H.1    Atta, J.2    Bruecher, J.3    Elsner, S.4    Schardt, C.5    Stadler, M.6
  • 12
    • 0036050143 scopus 로고    scopus 로고
    • Minimal residual disease levels in bone marrow and peripheral blood are comparable in children with T cell acute lymphoblastic leukemia (ALL), but not in precursor-B-ALL
    • van der Velden VH, Jacobs DC, Wijkhuijs AJ, Comans-Bitter WM, Willemse MJ, Hahlen K, et al. Minimal residual disease levels in bone marrow and peripheral blood are comparable in children with T cell acute lymphoblastic leukemia (ALL), but not in precursor-B-ALL. Leukemia. 2002;16(8): 1432-6.
    • (2002) Leukemia , vol.16 , Issue.8 , pp. 1432-1436
    • van der Velden, V.H.1    Jacobs, D.C.2    Wijkhuijs, A.J.3    Comans-Bitter, W.M.4    Willemse, M.J.5    Hahlen, K.6
  • 13
    • 0028909484 scopus 로고
    • Quantification of residual disease in Philadelphia-positive acute lymphoblastic leukemia: Comparison of blood and bone marrow
    • van Rhee F, Marks DI, Lin F, Szydlo RM, Hochhaus A, Treleaven J, et al. Quantification of residual disease in Philadelphia-positive acute lymphoblastic leukemia: comparison of blood and bone marrow. Leukemia. 1995;9(2):329-35.
    • (1995) Leukemia , vol.9 , Issue.2 , pp. 329-335
    • van Rhee, F.1    Marks, D.I.2    Lin, F.3    Szydlo, R.M.4    Hochhaus, A.5    Treleaven, J.6
  • 14
    • 0035171508 scopus 로고    scopus 로고
    • Molecular relapse can be detected in blood in a sensitive and timely fashion in B-lineage acute lymphoblastic leukemia
    • Brisco MJ, Sykes PJ, Hughes E, Story CJ, Rice MS, Schwarer AP, et al. Molecular relapse can be detected in blood in a sensitive and timely fashion in B-lineage acute lymphoblastic leukemia. Leukemia. 2001; 15(11):1801-2.
    • (2001) Leukemia , vol.15 , Issue.11 , pp. 1801-1802
    • Brisco, M.J.1    Sykes, P.J.2    Hughes, E.3    Story, C.J.4    Rice, M.S.5    Schwarer, A.P.6
  • 15
    • 43749100248 scopus 로고    scopus 로고
    • Minimal residual disease (MRD) analysis in the non- MRD-based ALL IC-BFM 2002 protocol for childhood ALL: Is it possible to avoid MRD testing?
    • Fronkova E, Mejstrikova E, Avigad S, Chik KW, Castillo L, Manor S, et al. Minimal residual disease (MRD) analysis in the non- MRD-based ALL IC-BFM 2002 protocol for childhood ALL: is it possible to avoid MRD testing? Leukemia. 2008;22(5):989-97.
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 989-997
    • Fronkova, E.1    Mejstrikova, E.2    Avigad, S.3    Chik, K.W.4    Castillo, L.5    Manor, S.6
  • 16
    • 20844460600 scopus 로고    scopus 로고
    • Correlation of CD33 with poorer prognosis in childhood ALL implicates a potential of anti-CD33 frontline therapy
    • Mejstrikova E, Kalina T, Trka J, Stary J, Hrusak O. Correlation of CD33 with poorer prognosis in childhood ALL implicates a potential of anti-CD33 frontline therapy. Leukemia. 2005;19(6):1092-4.
    • (2005) Leukemia , vol.19 , Issue.6 , pp. 1092-1094
    • Mejstrikova, E.1    Kalina, T.2    Trka, J.3    Stary, J.4    Hrusak, O.5
  • 18
    • 0031875110 scopus 로고    scopus 로고
    • Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TELAML1 negativity. The Pediatric Hematology Working Group in the Czech Republic
    • Hrusak O, Trka J, Zuna J, Houskova J, Bartunkova J, Stary J. Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TELAML1 negativity. The Pediatric Hematology Working Group in the Czech Republic. Leukemia. 1998;12(7):1064-70.
    • (1998) Leukemia , vol.12 , Issue.7 , pp. 1064-1070
    • Hrusak, O.1    Trka, J.2    Zuna, J.3    Houskova, J.4    Bartunkova, J.5    Stary, J.6
  • 19
    • 0032919213 scopus 로고    scopus 로고
    • Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: Report of the BIOMED-1 CONCERTED ACTION: Investigation of minimal residual disease in acute leukemia
    • Pongers-Willemse MJ, Seriu T, Stolz F, d'Aniello E, Gameiro P, Pisa P, et al. Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia. Leukemia. 1999; 13(1):110-8.
    • (1999) Leukemia , vol.13 , Issue.1 , pp. 110-118
    • Pongers-Willemse, M.J.1    Seriu, T.2    Stolz, F.3    D'Aniello, E.4    Gameiro, P.5    Pisa, P.6
  • 20
    • 0344654691 scopus 로고    scopus 로고
    • Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage
    • Szczepanski T, Pongers Willemse MJ, Langerak AW, Harts WA, Wijkhuijs AJ, van Wering ER, et al. Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage. Blood. 1999;93(12):4079-85.
    • (1999) Blood , vol.93 , Issue.12 , pp. 4079-4085
    • Szczepanski, T.1    Pongers, W.M.J.2    Langerak, A.W.3    Harts, W.A.4    Wijkhuijs, A.J.5    van Wering, E.R.6
  • 21
    • 9144265458 scopus 로고    scopus 로고
    • Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936
    • van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17(12):2257-317.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2257-2317
    • van Dongen, J.J.1    Langerak, A.W.2    Bruggemann, M.3    Evans, P.A.4    Hummel, M.5    Lavender, F.L.6
  • 22
    • 0035889144 scopus 로고    scopus 로고
    • Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells
    • Langerak AW, Wolvers-Tettero IL, van Gastel-Mol EJ, Oud ME, van Dongen JJ. Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells. Blood. 2001;98(8):2456-65.
    • (2001) Blood , vol.98 , Issue.8 , pp. 2456-2465
    • Langerak, A.W.1    Wolvers-Tettero, I.L.2    van Gastel-Mol, E.J.3    Oud, M.E.4    van Dongen, J.J.5
  • 23
    • 0036051771 scopus 로고    scopus 로고
    • T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis
    • van der Velden VH, Wijkhuijs JM, Jacobs DC, van Wering ER, van Dongen JJ. T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis. Leukemia. 2002;16(7):1372-80.
    • (2002) Leukemia , vol.16 , Issue.7 , pp. 1372-1380
    • van der Velden, V.H.1    Wijkhuijs, J.M.2    Jacobs, D.C.3    van Wering, E.R.4    van Dongen, J.J.5
  • 24
    • 0036114311 scopus 로고    scopus 로고
    • Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR
    • van der Velden VH, Willemse MJ, van der Schoot CE, Hahlen K, van Wering ER, van Dongen JJ. Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR. Leukemia. 2002;16(5):928-36.
    • (2002) Leukemia , vol.16 , Issue.5 , pp. 928-936
    • van der Velden, V.H.1    Willemse, M.J.2    van der Schoot, C.E.3    Hahlen, K.4    van Wering, E.R.5    van Dongen, J.J.6
  • 25
    • 0033894921 scopus 로고    scopus 로고
    • Application of germline IGH probes in realtime quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia
    • Verhagen OJ, Willemse MJ, Breunis WB, Wijkhuijs AJ, Jacobs DC, Joosten SA, et al. Application of germline IGH probes in realtime quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia. Leukemia. 2000;14(8): 1426-35.
    • (2000) Leukemia , vol.14 , Issue.8 , pp. 1426-1435
    • Verhagen, O.J.1    Willemse, M.J.2    Breunis, W.B.3    Wijkhuijs, A.J.4    Jacobs, D.C.5    Joosten, S.A.6
  • 26
    • 21744447214 scopus 로고    scopus 로고
    • TEL/AML 1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL
    • Fronkova E, Madzo J, Zuna J, Reznickova L, Muzikova K, Hrusak O, et al. TEL/AML 1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL. Leukemia. 2005;19(7):1296-7.
    • (2005) Leukemia , vol.19 , Issue.7 , pp. 1296-1297
    • Fronkova, E.1    Madzo, J.2    Zuna, J.3    Reznickova, L.4    Muzikova, K.5    Hrusak, O.6
  • 27
    • 33947362505 scopus 로고    scopus 로고
    • Analysis of minimal residual disease by Ig/TCR gene rearrangements: Guidelines for interpretation of realtime quantitative PCR data
    • van der Velden VH, Cazzaniga G, Schrauder A, Hancock J, Bader P, Panzer-Grumayer ER, et al. Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of realtime quantitative PCR data. Leukemia. 2007;21(4):604-11.
    • (2007) Leukemia , vol.21 , Issue.4 , pp. 604-611
    • van der Velden, V.H.1    Cazzaniga, G.2    Schrauder, A.3    Hancock, J.4    Bader, P.5    Panzer-Grumayer, E.R.6
  • 28
    • 0034141517 scopus 로고    scopus 로고
    • Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia
    • Panzer Grumayer ER, Schneider M, Panzer S, Fasching K, Gadner H. Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia. Blood. 2000;95(3):790-4.
    • (2000) Blood , vol.95 , Issue.3 , pp. 790-794
    • Panzer, G.E.R.1    Schneider, M.2    Panzer, S.3    Fasching, K.4    Gadner, H.5
  • 29
    • 67650478894 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia
    • Sutton R, Venn NC, Tolisano J, Bahar AY, Giles JE, Ashton LJ, et al. Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia. Br J Haematol. 2009;146(3):292-9.
    • (2009) Br J Haematol , vol.146 , Issue.3 , pp. 292-299
    • Sutton, R.1    Venn, N.C.2    Tolisano, J.3    Bahar, A.Y.4    Giles, J.E.5    Ashton, L.J.6
  • 30
    • 70449711125 scopus 로고    scopus 로고
    • Risk of relapse of childhood acute lymphoblastic leukemia is predicted by flow cytometric measurement of residual disease on day 15 bone marrow
    • Basso G, Veltroni M, Valsecchi MG, Dworzak MN, Ratei R, Silvestri D, et al. Risk of relapse of childhood acute lymphoblastic leukemia is predicted by flow cytometric measurement of residual disease on day 15 bone marrow. J Clin Oncol. 2009;27(31):5168-74.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5168-5174
    • Basso, G.1    Veltroni, M.2    Valsecchi, M.G.3    Dworzak, M.N.4    Ratei, R.5    Silvestri, D.6
  • 32
    • 62549104850 scopus 로고    scopus 로고
    • Monitoring treatment response of childhood precursor Bcell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: Predictive impact of early blast reduction on the remission status after induction
    • Ratei R, Basso G, Dworzak M, Gaipa G, Veltroni M, Rhein P, et al. Monitoring treatment response of childhood precursor Bcell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: predictive impact of early blast reduction on the remission status after induction. Leukemia. 2009;23(3):528-34.
    • (2009) Leukemia , vol.23 , Issue.3 , pp. 528-534
    • Ratei, R.1    Basso, G.2    Dworzak, M.3    Gaipa, G.4    Veltroni, M.5    Rhein, P.6
  • 33
    • 0030795348 scopus 로고    scopus 로고
    • Abdominal ultrasound findings during and after treatment of childhood acute lymphoblastic leukemia
    • Ojala AE, Lanning FP, Lanning BM. Abdominal ultrasound findings during and after treatment of childhood acute lymphoblastic leukemia. Med Pediatr Oncol. 1997;29(4):266-71.
    • (1997) Med Pediatr Oncol , vol.29 , Issue.4 , pp. 266-271
    • Ojala, A.E.1    Lanning, F.P.2    Lanning, B.M.3
  • 34
    • 0028152851 scopus 로고
    • Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86
    • Reiter A, Schrappe M, Ludwig WD, Hiddemann W, Sauter S, Henze G, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood. 1994; 84(9):3122-33.
    • (1994) Blood , vol.84 , Issue.9 , pp. 3122-3133
    • Reiter, A.1    Schrappe, M.2    Ludwig, W.D.3    Hiddemann, W.4    Sauter, S.5    Henze, G.6
  • 35
    • 0032482394 scopus 로고    scopus 로고
    • Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy
    • Nachman JB, Sather HN, Sensel MG, Trigg ME, Cherlow JM, Lukens JN, et al. Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy. N Engl J Med. 1998;338(23):1663-71.
    • (1998) N Engl J Med , vol.338 , Issue.23 , pp. 1663-1671
    • Nachman, J.B.1    Sather, H.N.2    Sensel, M.G.3    Trigg, M.E.4    Cherlow, J.M.5    Lukens, J.N.6
  • 36
    • 3042581215 scopus 로고    scopus 로고
    • Evolution of BFM trials for childhood ALL
    • Schrappe M. Evolution of BFM trials for childhood ALL. Ann Hematol. 2004;83 (Suppl 1):S121-3.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Schrappe, M.1
  • 37
    • 47049093795 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A Children's Oncology Group study
    • Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL, et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study. Blood. 2008;111(12):5477-85.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5477-5485
    • Borowitz, M.J.1    Devidas, M.2    Hunger, S.P.3    Bowman, W.P.4    Carroll, A.J.5    Carroll, W.L.6


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