The combination of structural parameters and areal bone mineral density improves relation to proximal femur strength: An in vitro study with high-resolution peripheral quantitative computed tomography

Calcified Tissue International

Volumn 89, Issue 4, 2011, Pages 335-346

  Hansen, Stinus ^a,b   Jensen, Jens Erik Beck ^c   Ahrberg, Fabian ^a   Hauge, Ellen M ^d   Brixen, Kim ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Bone densitometry; Bone structure; HR pQCT; Osteoporosis; Proximal femur

Indexed keywords

ADULT; AGED; AREAL BONE MINERAL DENSITY; ARTICLE; BIOMECHANICS; BONE DENSITOMETRY; BONE DENSITY; BONE MINERAL; BONE STRENGTH; BONE STRUCTURE; CLINICAL ARTICLE; COMPRESSIVE STRENGTH; CONTROLLED STUDY; CORTICAL BONE; CYTOARCHITECTURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR HEAD; FEMUR NECK; GEOMETRY; GREATER TROCHANTER; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LESSER TROCHANTER; MALE; MAXIMAL COMPRESSIVE STRENGTH; PRIORITY JOURNAL; REPRODUCIBILITY; TRABECULAR BONE;

ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; BIOMECHANICS; BONE DENSITY; COMPRESSIVE STRENGTH; COMPUTER SIMULATION; FEMALE; FEMUR; FEMUR HEAD; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 82755189527     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-011-9523-z     Document Type: Article

References (41)

1. Vestergaard P, Rejnmark L, Mosekilde L (2007) Increased mortality in patients with a hip fracture - effect of pre-morbid conditions and post-fracture complications. Osteoporos Int 18:1583-1593 (Pubitemid 47620310)
2. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis- related fractures in the United States, 2005-2025. J Bone Miner Res 22:465-475 (Pubitemid 46797130)
3. Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14(Suppl 3):S13-S18
4. Wainwright SA, Marshall LM, Ensrud KE, Cauley JA, Black DM, Hillier TA, Hochberg MC, Vogt MT, Orwoll ES (2005) Hip fracture in women without osteoporosis. J Clin Endocrinol Metab 90:2787-2793 (Pubitemid 40686325)
5. Kanis JA, Johnell O, Oden A, Dawson A, De LC, Jonsson B (2001) Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int 12:989-995 (Pubitemid 34105967)
6. Link TM, Vieth V, Langenberg R, Meier N, Lotter A, Newitt D, Majumdar S (2003) Structure analysis of high resolution magnetic resonance imaging of the proximal femur: in vitro correlation with biomechanical strength and BMD. Calcif Tissue Int 72:156-165 (Pubitemid 36919536)
7. Baum T, Carballido-Gamio J, Huber MB, Muller D, Monetti R, Rath C, Eckstein F, Lochmuller EM, Majumdar S, Rummeny EJ, Link TM, Bauer JS (2010) Automated 3D trabecular bone structure analysis of the proximal femur - prediction of biomechanical strength by CT and DXA. Osteoporos Int 21:1553-1564
8. Bauer JS, Kohlmann S, Eckstein F, Mueller D, Lochmuller EM, Link TM (2006) Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro. Calcif Tissue Int 78:78-89
9. Lang TF, Keyak JH, Heitz MW, Augat P, Lu Y, Mathur A, Genant HK (1997) Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength. Bone 21:101-108 (Pubitemid 27341746)
10. Bousson V, Le BA, Roqueplan F, Kang Y, Mitton D, Kolta S, Bergot C, Skalli W, Vicaut E, Kalender W, Engelke K, Laredo JD (2006) Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 17:855-864 (Pubitemid 43781499)
11. Manske SL, Liu-Ambrose T, de Bakker PM, Liu D, Kontulainen S, Guy P, Oxland TR, McKay HA (2006) Femoral neck cortical geometry measured with magnetic resonance imaging is associated with proximal femur strength. Osteoporos Int 17:1539-1545 (Pubitemid 44387489)
12. Manske SL, Liu-Ambrose T, Cooper DM, Kontulainen S, Guy P, Forster BB, McKay HA (2009) Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction. Osteoporos Int 20:445-453
13. Cheng XG, Lowet G, Boonen S, Nicholson PH, Brys P, Nijs J, Dequeker J (1997) Assessment of the strength of proximal femur in vitro: relationship to femoral bone mineral density and femoral geometry. Bone 20:213-218 (Pubitemid 27141832)
14. Eckstein F, Matsuura M, Kuhn V, Priemel M, Muller R, Link TM, Lochmuller EM (2007) Sex differences of human trabecular bone microstructure in aging are site-dependent. J Bone Miner Res 22:817-824 (Pubitemid 351339741)
15. Link TM, Vieth V, Stehling C, Lotter A, Beer A, Newitt D, Majumdar S (2003) High-resolution MRI vs multislice spiral CT: Which technique depicts the trabecular bone structure best? Eur Radiol 13:663-671 (Pubitemid 36790545)
16. Bauer JS, Link TM (2009) Advances in osteoporosis imaging. Eur J Radiol 71:440-449
17. Hildebrand T, Ruegsegger P (1997) A new method for the model independent assessment of thickness in three-dimensional images. J Microsc 185:67-75 (Pubitemid 27060526)
18. Laib A, Hildebrand T, Hauselmann HJ, Ruegsegger P (1997) Ridge number density: a new parameter for in vivo bone structure analysis. Bone 21:541-546 (Pubitemid 28029698)
19. Laib A, Ruegsegger P (1999) Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-micron-resolution microcomputed tomography. Bone 24:35-39 (Pubitemid 28546704)
20. MacNeil JA, Boyd SK (2007) Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 29:1096-1105 (Pubitemid 350052626)
21. Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK (2007) Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro- CT bone analysis. Bone 41:505-515 (Pubitemid 47385446)
22. Nielsen SP, Slosman D, Sorensen OH, Basse-Cathalinat B, De CP, Roux CR, Meunier PJ (1999) Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry. J Clin Densitom 2:371-379
23. Beck TJ, Ruff CB, Warden KE, Scott WW Jr, Rao GU (1990) Predicting femoral neck strength from bone mineral data. A structural approach. Investig Radiol 25:6-18 (Pubitemid 20040519)
24. Mayhew PM, Thomas CD, Clement JG, Loveridge N, Beck TJ, Bonfield W, Burgoyne CJ, Reeve J (2005) Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 366:129-135 (Pubitemid 40991213)
25. Verhulp E, Van RB, Huiskes R (2008) Load distribution in the healthy and osteoporotic human proximal femur during a fall to the side. Bone 42:30-35
26. de Bakker PM, Manske SL, Ebacher V, Oxland TR, Cripton PA, Guy P (2009) During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures. J Biomech 42:1917-1925
27. Bouxsein ML, Fajardo RJ (2005) Cortical stability of the femoral neck and hip fracture risk. Lancet 366:1523-1524
28. Turner CH (2005) The biomechanics of hip fracture. Lancet 366:98-99 (Pubitemid 40991193)
29. Sugiyama T, Taguchi T (2005) Cortical stability of the femoral neck and hip fracture risk. Lancet 366:1525-1526
30. Zebaze RM, Seeman E (2005) Cortical stability of the femoral neck and hip fracture risk. Lancet 366:1523-1525
31. Wachter NJ, Augat P, Mentzel M, Sarkar MR, Krischak GD, Kinzl L, Claes LE (2001) Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur. Bone 28:133-139 (Pubitemid 32112073)
32. Link TM, Majumdar S, Lin JC, Newitt D, Augat P, Ouyang X, Mathur A, Genant HK (1998) A comparative study of trabecular bone properties in the spine and femur using high resolution MRI and CT. J Bone Miner Res 13:122-132 (Pubitemid 28063121)
33. Cody DD, McCubbrey DA, Divine GW, Gross GJ, Goldstein SA (1996) Predictive value of proximal femoral bone densitometry in determining local orthogonal material properties. J Biomech 29:753-761 (Pubitemid 26137410)
34. Huber MB, Carballido-Gamio J, Bauer JS, Baum T, Eckstein F, Lochmuller EM, Majumdar S, Link TM (2008) Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT - correlation with biomechanical strength measurement. Radiology 247:472-481
35. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES (2008) Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res 23:1326-1333 (Pubitemid 352040188)
36. Johannesdottir F, Poole KE, Reeve J, Siggeirsdottir K, Aspelund T, Mogensen B, Jonsson BY, Sigurdsson S, Harris TB, Gudnason VG, Sigurdsson G (2011) Distribution of cortical bone in the femoral neck and hip fracture: a prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study. Bone 48:1268-1276
37. Courtney AC, Wachtel EF, Myers ER, Hayes WC (1994) Effects of loading rate on strength of the proximal femur. Calcif Tissue Int 55:53-58 (Pubitemid 24192838)
38. Yang KH, Shen KL, Demetropoulos CK, King AI, Kolodziej P, Levine RS, Fitzgerald RH Jr (1996) The relationship between loading conditions and fracture patterns of the proximal femur. J Biomech Eng 118:575-578 (Pubitemid 26397094)
39. Pinilla TP, Boardman KC, Bouxsein ML, Myers ER, Hayes WC (1996) Impact direction from a fall influences the failure load of the proximal femur as much as age-related bone loss. Calcif Tissue Int 58:231-235 (Pubitemid 26097904)
40. Cody DD, Gross GJ, Hou FJ, Spencer HJ, Goldstein SA, Fyhrie DP (1999) Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech 32:1013-1020 (Pubitemid 29356040)
41. Li W, Kornak J, Harris T, Keyak J, Li C, Lu Y, Cheng X, Lang T (2009) Identify fracture-critical regions inside the proximal femur using statistical parametric mapping. Bone 44:596-602