Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape

Journal of Immunology

Volumn 187, Issue 11, 2011, Pages 5596-5605

  Duong, Bao Hoa ^a,c   Ota, Takayuki ^a   Aoki Ota, Miyo ^a   Cooper, Anthony Byron ^a   Ait Azzouzene, Djemel ^a,d   Vela, José Luis ^a,e   Gavin, Amanda Lee ^b   Nemazee, David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BURNET INSTITUTE   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d PFIZER INC   (United States)

^e LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD19 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; SUPERANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW; BONE MARROW CELL; CELL MATURATION; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE EXPRESSION PROFILING; GENE MUTATION; IGH GENE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL TOLERANCE; INTERNALIZATION; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; TRANSGENE; WILD TYPE;

ANIMALS; AUTOANTIGENS; B-LYMPHOCYTES; CELL SEPARATION; CENTRAL TOLERANCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNE TOLERANCE; IMMUNOGLOBULIN M; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPERANTIGENS;

EID: 82755186768     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102479     Document Type: Article

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