False normal von Willebrand factor activity by monoclonal antibody-based ELISA in a patient with type 2A(IID) von Willebrand disease

Thrombosis and Haemostasis

Volumn 106, Issue 6, 2011, Pages 1224-1225

  Ahmad, Sufian ^a   Ptashkin, Beverly ^a   Digiovanni, Cara ^a   Cines, Douglas B ^a   Konkle, Barbara A ^b   Cuker, Adam ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PUGET SOUND BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; MONOCLONAL ANTIBODY; VON WILLEBRAND FACTOR;

ADULT; CASE REPORT; CLINICAL FEATURE; CRYOPRECIPITATE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPISTAXIS; FEMALE; GINGIVA BLEEDING; HEMARTHROSIS; HETEROZYGOSITY; HUMAN; LETTER; MENORRHAGIA; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN BRUISING; VON WILLEBRAND DISEASE; VON WILLEBRAND DISEASE TYPE 2A;

ANTIBODIES, MONOCLONAL; BLOOD COAGULATION; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; MIDDLE AGED; MUTATION; PROTEIN MULTIMERIZATION; VON WILLEBRAND DISEASE, TYPE 2; VON WILLEBRAND FACTOR;

EID: 82555193846     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-07-0484     Document Type: Letter

References (18)

1. Castaman G, Montgomery RR, Meschengieser SS, et al. von Willebrand's disease diagnosis and laboratory issues. Haemophilia 2010; 16 (Suppl 5): 67-73.
2. Favaloro EJ, Koutts J. Laboratory assays for von Willebrand factor: relative contribution to the diagnosis of von Willebrand's disease. Pathology 1997; 29: 385-391.
3. Flood VH, Friedman KD, Gill JC, et al. Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function. J Thromb Haemost 2009; 7: 1832-1839.
4. Flood VH, Gill JC, Morateck PA, et al. Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. Blood 2010; 116: 280-286.
5. abp von Willebrand Factor Activity Test Kit package insert. Available upon request at: http://www.abpcorp.com/activity%20kit/default.html. Accessed June 28, 2011.
6. Goodall AH, Jarvis J, Chand S, et al. An immunoradiometric assay for human factor VIII/von Willebrand factor (VIII:vWF) using a monoclonal antibody that defines a functional epitope. Br J Haematol 1985; 59: 565-577.
7. Murdock PJ, Woodhams BJ, Matthews KB, et al. Von Willebrand factor activity detected in a monoclonal antibody-based ELISA: an alternative to the ristocetin cofactor platelet agglutination assay for diagnostic use. Thromb Haemost 1997; 78: 1272-1277.
8. Tosetto A, Rodeghiero F, Castaman G, et al. A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD). J Thromb Haemost 2006; 4: 766-773.
9. De Vleeschauwer A, Devreese K. Comparison of a new automated von Willebrand factor activity assay with an aggregation von Willebrand ristocetin cofactor activity assay for the diagnosis of von Willebrand disease. Blood Coagul Fibrinolysis 2006; 17: 353-358.
10. Tjernberg P, Vos HL, Spaargaren-van Riel CC, et al. Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease. Thromb Haemost 2006; 96: 717-724.
11. Sadler JE. Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem 1998; 67: 395-424.
12. Wagner DD, Lawrence SO, Ohlsson-Wilhelm, et al. Topology and order of formation of interchain disulfide bonds in von Willebrand factor. Blood 1987; 69: 27-32.
13. Lynch DC, Williams R, Zimmerman TS, et al. Biosynthesis of the subunits of factor VIIIR by bovin aortic endothelial cells. Proc Natl Acad Sci USA 1983; 80: 2738-2742.
14. ISTH-SSC VWF Online Database. Available at: http://www.ragtimedesign.com/vwf/mutation/mutationtableresults.php. Accessed June 28, 2011.
15. Preston FE. Assays for von Willebrand factor functional activity: a UK NEQAS survey. Thromb Haemost 1998; 80: 863.
16. Favaloro EJ. Detection of von Willebrand disorder and identification of qualitative von Willebrand factor defects. Am J Clin Pathol 2000; 114: 608-618.
17. Nitu-Whalley IC, Riddell A, Lee CA, et al. Identification of type 2 von Willebrand disease in previously diagnosed type 1 patients: a reappraisal using phenotypes, genotypes and molecular modeling. Thromb Haemost 2000; 84: 998-1004.
18. Vanhoorelbeke K, Cauwenberghs N, Vauterin S, et al. A reliable and reproducible ELISA Method to measure ristocetin cofactor activity of von Willebrand factor. Thromb Haemost 2000; 83: 107-113.