Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections

Microbiology

Volumn 157, Issue 12, 2011, Pages 3429-3434

  Kropec, A ^a   Sava, I G ^a   Vonend, C ^a   Sakinc, T ^a   Grohmann, E ^a   Huebner, J ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SAGA ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; CONTROLLED STUDY; ENTEROCOCCAL INFECTION; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEMALE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTEREMIA; BACTERIAL LOAD; BACTERIAL VACCINES; BLOOD; DISEASE MODELS, ANIMAL; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GRAM-POSITIVE BACTERIAL INFECTIONS; MICE; MICE, INBRED BALB C; OPSONIN PROTEINS; PHAGOCYTOSIS; RABBITS; RECOMBINANT PROTEINS; VACCINES, SYNTHETIC;

EID: 82555191256     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.053207-0     Document Type: Article

References (31)

1. Anantharaman, V. & Aravind, L. (2003). Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol 4, R11.
2. Arias, C. A. & Murray, B. E. (2009). Antibiotic-resistant bugs in the 21st century-a clinical super-challenge. N Engl J Med 360, 439-443
3. Arias, C. A., Contreras, G. A. & Murray, B. E. (2010). Management of multidrug-resistant enterococcal infections. Clin Microbiol Infect 16, 555-562
4. Blake, M. S., Johnston, K. H., Russell-Jones, G. J. & Gotschlich, E. C. (1984). A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots. Anal Biochem 136, 175-179
5. Breton, Y. L., Mazé, A., Hartke, A., Lemarinier, S., Auffray, Y. & Rincé, A. (2002). Isolation and characterization of bile salts-sensitive mutants of Enterococcus faecalis. Curr Microbiol 45, 434-439
6. Bubert, A., Kuhn, M., Goebel, W. & Köhler, S. (1992). Structural and functional properties of the p60 proteins from different Listeria species. J Bacteriol 174, 8166-8171
7. Butler, A. M., Olsen, M. A., Merz, L. R., Guth, R. M., Woeltje, K. F., Camins, B. C. & Fraser, V. J. (2010). Attributable costs of enterococcal bloodstream infections in a nonsurgical hospital cohort. Infect Control Hosp Epidemiol 31, 28-35
8. Chia, J.-S., Chang, L. Y., Shun, C.-T., Chang, Y.-Y., Tsay, Y. G. & Chen, J. Y. (2001). A 60-kilodalton immunodominant glycoprotein is essential for cell wall integrity and the maintenance of cell shape in Streptococcus mutans. Infect Immun 69, 6987-6998
9. Heikens, E., Bonten, M. J. M. & Willems, R. J. L. (2007). Enterococcal surface protein Esp is important for biofilm formation of Enterococcus faecium E1162. J Bacteriol 189, 8233-8240
10. Herrero, I. A., Issa, N. C. & Patel, R. (2002). Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. N Engl J Med 346, 867-869
11. Huebner, J., Wang, Y., Krueger, W. A., Madoff, L. C., Martirosian, G., Boisot, S., Goldmann, D. A., Kasper, D. L., Tzianabos, A. O. & Pier, G. B. (1999). Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium. Infect Immun 67, 1213-1219
12. Huebner, J., Quaas, A., Krueger, W. A., Goldmann, D. A. & Pier, G. B. (2000). Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and-resistant enterococci. Infect Immun 68, 4631-4636
13. Koch, S., Hufnagel, M. & Huebner, J. (2004). Treatment and prevention of enterococcal infections-alternative and experimental approaches. Expert Opin Biol Ther 4, 1519-1531
14. Le Breton, Y., Boël, G., Benachour, A., Prévost, H., Auffray, Y. & Rincé, A. (2003). Molecular characterization of Enterococcus faecalis two-component signal transduction pathways related to environmental stresses. Environ Microbiol 5, 329-337
15. Leavis, H. L., Willems, R. J. L., van Wamel, W. J. B., Schuren, F. H., Caspers, M. P. M. & Bonten, M. J. M. (2007). Insertion sequencedriven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium. PLoS Pathog 3, e7.
16. Maira-Litrán, T., Kropec, A., Abeygunawardana, C., Joyce, J., Mark, G., III, Goldmann, D. A. & Pier, G. B. (2002). Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide. Infect Immun 70, 4433-4440
17. Mohamed, J. A., Teng, F., Nallapareddy, S. R. & Murray, B. E. (2006). Pleiotropic effects of 2 Enterococcus faecalis sagA-like genes, salA and salB, which encode proteins that are antigenic during human infection, on biofilm formation and binding to collagen type i and fibronectin. J Infect Dis 193, 231-240
18. Rigden, D. J., Jedrzejas, M. J. & Galperin, M. Y. (2003). Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases. Trends Biochem Sci 28, 230-234
19. Sambrook, J. & Russell, D. W. (2001). Molecular Cloning, a Laboratory Manual, 3rd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
20. Sava, I. G., Heikens, E., Kropec, A., Theilacker, C., Willems, R. & Huebner, J. (2010). Enterococcal surface protein contributes to persistence in the host but is not a target of opsonic and protective antibodies in Enterococcus faecium infection. J Med Microbiol 59, 1001-1004
21. Schubert, K., Bichlmaier, A. M., Mager, E., Wolff, K., Ruhland, G. & Fiedler, F. (2000). P45, an extracellular 45 kDa protein of Listeria monocytogenes with similarity to protein p60 and exhibiting peptidoglycan lytic activity. Arch Microbiol 173, 21-28
22. Schwartz, B. S., Ngo, P. D. & Guglielmo, B. J. (2008). Daptomycin treatment failure for vancomycin-resistant Enterococcus faecium infective endocarditis: impact of protein binding? Ann Pharmacother 42, 289-290
23. Singh, K. V., Nallapareddy, S. R., Sillanpää, J. & Murray, B. E. (2010). Importance of the collagen adhesin ace in pathogenesis and protection against Enterococcus faecalis experimental endocarditis. PLoS Pathog 6, e1000716.
24. Teng, F., Kawalec, M., Weinstock, G. M., Hryniewicz, W. & Murray, B. E. (2003). An Enterococcus faecium secreted antigen, SagA, exhibits broad-spectrum binding to extracellular matrix proteins and appears essential for E. faecium growth. Infect Immun 71, 5033-5041
25. Theilacker, C., Krueger, W. A., Kropec, A. & Huebner, J. (2004). Rationale for the development of immunotherapy regimens against enterococcal infections. Vaccine 22 (Suppl. 1), S31-S38.
26. Theilacker, C., Kaczynski, Z., Kropec, A., Fabretti, F., Sange, T., Holst, O. & Huebner, J. (2006). Opsonic antibodies to Enterococcus faecalis strain 12030 are directed against lipoteichoic acid. Infect Immun 74, 5703-5712
27. Theilacker, C., Jonas, D., Huebner, J., Bertz, H. & Kern, W. V. (2009a). Outcomes of invasive infection due to vancomycin-resistant Enterococcus faecium during a recent outbreak. Infection 37, 540-543
28. Theilacker, C., Sanchez-Carballo, P., Toma, I., Fabretti, F., Sava, I., Kropec, A., Holst, O. & Huebner, J. (2009b). Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis. Mol Microbiol 71, 1055-1069
29. Theilacker, C., Kaczyński, Z., Kropec, A., Sava, I., Ye, L., Bychowska, A., Holst, O. & Huebner, J. (2011). Serodiversity of opsonic antibodies against Enterococcus faecalis-glycans of the cell wall revisited. PLoS ONE 6, e17839.
30. Top, J., Willems, R. J. L., van der Velden, S., Asbroek, M. & Bonten, M. (2008). Emergence of clonal complex 17 Enterococcus faecium in The Netherlands. J Clin Microbiol 46, 214-219
31. Willems, R. J. L., Top, J., van Santen, M., Robinson, D. A., Coque, T. M., Baquero, F., Grundmann, H. & Bonten, M. J. M. (2005). Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex. Emerg Infect Dis 11, 821-828.