Attaining realistic and substantial reductions in HIV incidence: Model projections of combining microbicide and male circumcision interventions in rural Uganda

Sexually Transmitted Infections

Volumn 87, Issue 7, 2011, Pages 635-639

  Cox, Andrew P ^a   Foss, Anna M ^a   Shafer, Leigh Anne ^b   Nsubuga, Rebecca N ^b   Vickerman, Peter ^a   Hayes, Richard J ^a   Watts, Charlotte ^a   White, Richard G ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

MICROBICIDE;

ADOLESCENT; ADULT; ARTICLE; CIRCUMCISION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROBABILITY; RURAL AREA; SEXUAL INTERCOURSE; SEXUAL TRANSMISSION; UGANDA; VIRUS TRANSMISSION;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; CIRCUMCISION, MALE; COMMUNICABLE DISEASE CONTROL; COMPUTER SIMULATION; DISEASE TRANSMISSION, INFECTIOUS; FEMALE; HIV INFECTIONS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MODELS, STATISTICAL; RURAL POPULATION; UGANDA; YOUNG ADULT;

EID: 82555191105     PISSN: 13684973     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/sti.2010.046227     Document Type: Article

References (30)

1. International Partnership for Microbicides. Giving women the power over AIDS. http://www.ipmglobal.org/sites/international.ixm.ca/files/Giving-Women- Power-Over-AIDS.pdf (accessed Jul 2011).
2. Microbicides Development Programme. Microbicides for HIV prevention. 2010. http://www.mdp.mrc.ac.uk/what.html (accessed May 2010).
3. Miedema F. A brief history of HIV vaccine research: stepping back to the drawing board? AIDS 2008;22:1699-703.
4. Vaccine Trials Network. HVTN Global Trial Sites. 2009. http://www.hvtn.org/media/FactSheet.pdf (accessed 21 Apr 2009).
5. Kersh EN, Luo W, Adams DR, et al. Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques. AIDS Res Hum Retroviruses 2008;24:543-6. (Pubitemid 351571040)
6. AVAC: Global Advocacy for HIV Prevention. Ongoing and planned PrEP trials as of February 2011. http://www.avac.org/ht/a/GetDocumentAction/i/3113 (accessed Jul 2011).
7. Auvert B, Taljaard D, Lagarde E, et al. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 trial. PLoS Med 2005;2:e298.
8. Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 2007;369:657-66.
9. Bailey RC, Moses S, Parker CB, et al. Male circumcison for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet 2007;369:643-56. (Pubitemid 46281312)
10. Wawer MJ, Makumbi F, Kigozi G, et al. Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial. Lancet 2009;374:229-37.
11. MacPhail C, Terris-Prestholt F, Kumaranayake L, et al. Managing men: women's dilemmas about overt and covert use of barrier methods for HIV prevention. Cult Health Sex 2009;11:485-97.
12. Gollub EL. Choice is empowering: getting strategic about preventing HIV infection in women. Int Fam Plan Perspect 2006;32:209-12.
13. UNFPA Women and HIV/AIDS: confronting the crisis. 2008. http://www.unfpa.org/hiv/women/docs/women-aids.pdf (accessed Jul 2011).
14. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010;329:1168-74.
15. Bass F. A new product growth model for consumer durables. Management Science 1969;15:215-27.
16. Rogers E. The Diffusion Of Innovations. New York: The Free Press, 1962.
17. Vickerman P, Terris-Prestholt F, Delany S, et al. Are targeted HIV prevention activities cost-effective in high prevalence settings? Results from a sexually transmitted infection treatment project for sex workers in Johannesburg, South Africa. Sex Transm Dis 2006;33(10 Suppl):S122-32. (Pubitemid 44454726)
18. White RG, Orroth KK, Korenromp EL, et al. Can population differences explain the contrasting results of the Mwanza, Rakai, and Masaka HIV/sexually transmitted disease intervention trials? a modeling study. J Acquir Immune Defic Syndr 2004;37:1500-13. (Pubitemid 39602341)
19. Sexton J, Garnett G, Rottingen JA. Metaanalysis and metaregression in interpreting study variability in the impact of sexually transmitted diseases on susceptibility to HIV infection. Sex Transm Dis 2005;32:351-7. (Pubitemid 40727179)
20. Rottingen JA, Cameron DW, Garnett GP. A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: how much really is known? Sex Transm Dis 2001;28:579-97. (Pubitemid 32937567)
21. Laga M, Manoka A, Kivuvu M, et al. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 1993;7:95-102. (Pubitemid 23069039)
22. Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005;191:1403-9. (Pubitemid 40563350)
23. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000;342:921-9. (Pubitemid 30177052)
24. Pilcher CD, Tien HC, Eron JJ Jr, et al. Brief but efficient: acute HIV infection and the sexual transmission of HIV. J Infect Dis 2004;189:1785-92. (Pubitemid 38657214)
25. Shafer LA, Biraro S, Nakiyingi-Miiro J, et al. HIV prevalence and incidence are no longer falling in southwest Uganda: evidence from a rural population cohort 1989-2005. AIDS 2008;22:1641-9.
26. Seeley J, Wagner U, Mulemwa J, et al. The development of a community-based HIV/AIDS counselling service in a rural area in Uganda. AIDS Care 1991;3:207-17.
27. Serwadda D, Mugerwa RD, Sewankambo NK, et al. Slim disease: a new disease in Uganda and its association with HTLV-III infection. Lancet 1985;2:849-52. (Pubitemid 16242661)
28. Saxinger W, Blattner WA, Levine PH, et al. Human T-cell leukemia virus (HTLV-I) antibodies in Africa. Science 1984;225:1473-6. (Pubitemid 14033130)
29. Levy JA, Pan LZ, Beth-Giraldo E, et al. Absence of antibodies to the human immunodeficiency virus in sera from Africa prior to 1975. Proc Natl Acad Sci U S A 1986;83:7935-7. (Pubitemid 17183958)
30. Gray R, Azire J, Serwadda D, et al. Male circumcision and the risk of sexually transmitted infections and HIV in Rakai, Uganda. AIDS 2004;18:2428-30. (Pubitemid 40065911)