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Volumn 56, Issue 11, 2011, Pages 3296-3304

Ultra-rapid virological response, young age, low γ-GT/ALT-ratio, and absence of steatosis identify a subgroup of HCV genotype 3 patients who achieve SVR with IFN-α 2a monotherapy

Author keywords

Chronic hepatitis C virus infection; Monotherapy; Ribavirin; Treatment

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN; INTERLEUKIN 28B; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2A PLUS RIBAVIRIN; RECOMBINANT ALPHA2A INTERFERON;

EID: 82555187925     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1933-2     Document Type: Article
Times cited : (6)

References (46)
  • 1
    • 0030885469 scopus 로고    scopus 로고
    • Factors predictive of a beneficial response to therapy of hepatitis C
    • GL Davis JY Lau 1997 Factors predictive of a beneficial response to therapy of hepatitis C Hepatology 26 122S 127S 9305676 10.1002/hep.510260721 1:CAS:528:DyaK2sXmt1CktLw%3D (Pubitemid 27388084)
    • (1997) Hepatology , vol.26 , Issue.3 SUPPL.
    • Davis, G.L.1    Lau, J.Y.N.2
  • 2
    • 0029156655 scopus 로고
    • Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. the TriVeneto Viral Hepatitis Group
    • 7657272 1:CAS:528:DyaK2MXoslartb4%3D
    • L Chemello P Bonetti L Cavalletto F Talato V Donadon P Casarin F Belussi M Frezza F Noventa P Pontisso 1995 Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. The TriVeneto Viral Hepatitis Group Hepatology 22 700 706 7657272 1:CAS:528:DyaK2MXoslartb4%3D
    • (1995) Hepatology , vol.22 , pp. 700-706
    • Chemello, L.1    Bonetti, P.2    Cavalletto, L.3    Talato, F.4    Donadon, V.5    Casarin, P.6    Belussi, F.7    Frezza, M.8    Noventa, F.9    Pontisso, P.10
  • 3
    • 0029084933 scopus 로고
    • Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C
    • 7557850 10.1002/hep.1840220406 1:CAS:528:DyaK2MXptl2jsrc%3D
    • M Martinot-Peignoux P Marcellin M Pouteau C Castelnau N Boyer M Poliquin C Degott I Descombes B Le V Milotova 1995 Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C Hepatology 22 1050 1056 7557850 10.1002/hep.1840220406 1:CAS:528:DyaK2MXptl2jsrc%3D
    • (1995) Hepatology , vol.22 , pp. 1050-1056
    • Martinot-Peignoux, M.1    Marcellin, P.2    Pouteau, M.3    Castelnau, C.4    Boyer, N.5    Poliquin, M.6    Degott, C.7    Descombes, I.8    Le, B.9    Milotova, V.10
  • 4
    • 17844403232 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C
    • DOI 10.1053/jhep.2001.26371
    • KL Lindsay C Trepo T Heintges ML Shiffman SC Gordon JC Hoefs ER Schiff ZD Goodman M Laughlin R Yao JK Albrecht 2001 A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C Hepatology 34 395 403 11481625 10.1053/jhep.2001.26371 1:CAS:528:DC%2BD3MXmtVGqtLs%3D (Pubitemid 32702353)
    • (2001) Hepatology , vol.34 , Issue.2 , pp. 395-403
    • Lindsay, K.L.1    Trepo, C.2    Heintges, T.3    Shiffman, M.L.4    Gordon, S.C.5    Hoefs, J.C.6    Schiff, E.R.7    Goodman, Z.D.8    Laughlin, M.9    Yao, R.10    Albrecht, J.K.11
  • 7
    • 0032501714 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled trial of interferon α-2b with and without ribavirin for chronic hepatitis C
    • DOI 10.1016/S0140-6736(97)06088-1
    • O Reichard G Norkrans A Fryden JH Braconier A Sonnerborg O Weiland 1998 Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group Lancet 351 83 87 9439491 10.1016/S0140-6736(97)06088-1 1:CAS:528:DyaK1cXmsFSqtw%3D%3D (Pubitemid 28026633)
    • (1998) Lancet , vol.351 , Issue.9096 , pp. 83-87
    • Reichard, O.1    Norkrans, G.2    Fryden, A.3    Braconier, J.-H.4    Sonnerborg, A.5    Weiland, O.6
  • 9
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • DOI 10.1016/S0140-6736(01)06102-5
    • MP Manns JG McHutchison SC Gordon VK Rustgi M Shiffman R Reindollar ZD Goodman K Koury M Ling JK Albrecht 2001 Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial Lancet 358 958 965 11583749 10.1016/S0140-6736(01)06102-5 1:CAS:528:DC%2BD3MXntF2qtb8%3D (Pubitemid 32913521)
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.-H.9    Albrecht, J.K.10
  • 12
    • 10644264391 scopus 로고    scopus 로고
    • Treatment with pegylated interferon and ribavarin in HCV infection with genotype 2 or 3 for 14 weeks: A pilot study
    • DOI 10.1002/hep.20467
    • O Dalgard K Bjoro KB Hellum B Myrvang S Ritland K Skaug N Raknerud H Bell 2004 Treatment with pegylated interferon and ribavarin in HCV infection with genotype 2 or 3 for 14 weeks: a pilot study Hepatology 40 1260 1265 15558712 10.1002/hep.20467 1:CAS:528:DC%2BD2MXhslahsQ%3D%3D (Pubitemid 39656999)
    • (2004) Hepatology , vol.40 , Issue.6 , pp. 1260-1265
    • Dalgard, O.1    Bjoro, K.2    Hellum, K.B.3    Myrvang, B.4    Ritland, S.5    Skaug, K.6    Raknerud, N.7    Bell, H.8
  • 14
    • 62149152106 scopus 로고    scopus 로고
    • Peginterferon alpha-2a and ribavirin versus peginterferon alpha-2a monotherapy in early virological responders and peginterferon alpha-2a and ribavirin versus peginterferon alpha-2a, ribavirin and amantadine triple therapy in early virological nonresponders: The SMIEC II trial in naive patients with chronic hepatitis C
    • 18679072 10.1097/MEG.0b013e3282f5196c 1:CAS:528:DC%2BD1cXotFags74%3D
    • M Angelico B Koehler-Horst P Piccolo F Angelico S Gentile S Francioso P Tarquini RD Vecchia L Ponti G Pilleri A Barlattani A Grieco F Soccorsi P Guarascio L Demelia O Sorbello Z Rossi G Forlini S Zaru F Bandiera 2008 Peginterferon alpha-2a and ribavirin versus peginterferon alpha-2a monotherapy in early virological responders and peginterferon alpha-2a and ribavirin versus peginterferon alpha-2a, ribavirin and amantadine triple therapy in early virological nonresponders: the SMIEC II trial in naive patients with chronic hepatitis C Eur J Gastroenterol Hepatol 20 680 687 18679072 10.1097/MEG. 0b013e3282f5196c 1:CAS:528:DC%2BD1cXotFags74%3D
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 680-687
    • Angelico, M.1    Koehler-Horst, B.2    Piccolo, P.3    Angelico, F.4    Gentile, S.5    Francioso, S.6    Tarquini, P.7    Vecchia, R.D.8    Ponti, L.9    Pilleri, G.10    Barlattani, A.11    Grieco, A.12    Soccorsi, F.13    Guarascio, P.14    Demelia, L.15    Sorbello, O.16    Rossi, Z.17    Forlini, G.18    Zaru, S.19    Bandiera, F.20    more..
  • 15
    • 77950810323 scopus 로고    scopus 로고
    • Immediate virological response predicts the success of short-term peg-interferon monotherapy for chronic hepatitis C
    • 20333792 10.3748/wjg.v16.i12.1506 1:CAS:528:DC%2BC3cXkt1CrsLg%3D
    • M Yada A Masumoto N Yamashita K Motomura T Koyanagi S Sakamoto 2010 Immediate virological response predicts the success of short-term peg-interferon monotherapy for chronic hepatitis C World J Gastroenterol 16 1506 1511 20333792 10.3748/wjg.v16.i12.1506 1:CAS:528:DC%2BC3cXkt1CrsLg%3D
    • (2010) World J Gastroenterol , vol.16 , pp. 1506-1511
    • Yada, M.1    Masumoto, A.2    Yamashita, N.3    Motomura, K.4    Koyanagi, T.5    Sakamoto, S.6
  • 17
    • 24944552848 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C with interferon alone or combined with ribavirin in Japan
    • DOI 10.1159/000087273
    • T Kumada H Toyoda T Honda T Kuzuya Y Katano I Nakano H Goto 2006 Treatment of chronic hepatitis C with interferon alone or combined with ribavirin in Japan Intervirology 49 112 118 16166799 10.1159/000087273 1:CAS:528:DC%2BD2MXhtVWntr%2FK (Pubitemid 41318186)
    • (2006) Intervirology , vol.49 , Issue.1-2 , pp. 112-118
    • Kumada, T.1    Toyoda, H.2    Honda, T.3    Kuzuya, T.4    Katano, Y.5    Nakano, I.6    Goto, H.7
  • 18
    • 79953738444 scopus 로고    scopus 로고
    • Virological response is associated with decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in hepatitis C virus genotype 1
    • 21480317 10.1002/hep.24180 1:CAS:528:DC%2BC3MXktl2jurk%3D
    • W Sievert GJ Dore GW McCaughan M Yoshihara DH Crawford W Cheng M Weltman W Rawlinson B Rizkalla JK Depamphilis SK Roberts 2011 Virological response is associated with decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in hepatitis C virus genotype 1 Hepatology 53 1109 1117 21480317 10.1002/hep.24180 1:CAS:528:DC%2BC3MXktl2jurk%3D
    • (2011) Hepatology , vol.53 , pp. 1109-1117
    • Sievert, W.1    Dore, G.J.2    McCaughan, G.W.3    Yoshihara, M.4    Crawford, D.H.5    Cheng, W.6    Weltman, M.7    Rawlinson, W.8    Rizkalla, B.9    Depamphilis, J.K.10    Roberts, S.K.11
  • 19
    • 49349107315 scopus 로고    scopus 로고
    • Early predictors of anemia in patients with hepatitis C genotype 1 treated with peginterferon alfa-2a (40KD) plus ribavirin
    • 18796095 10.1111/j.1572-0241.2008.01957.x 1:CAS:528:DC%2BD1cXhtFGhurrI
    • N Reau SJ Hadziyannis D Messinger MW Fried DM Jensen 2008 Early predictors of anemia in patients with hepatitis C genotype 1 treated with peginterferon alfa-2a (40KD) plus ribavirin Am J Gastroenterol 103 1981 1988 18796095 10.1111/j.1572-0241.2008.01957.x 1:CAS:528:DC%2BD1cXhtFGhurrI
    • (2008) Am J Gastroenterol , vol.103 , pp. 1981-1988
    • Reau, N.1    Hadziyannis, S.J.2    Messinger, D.3    Fried, M.W.4    Jensen, D.M.5
  • 21
    • 33747056830 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 promoter polymorphism and the outcome of hepatitis C virus infection
    • DOI 10.1097/01.meg.0000224478.89545.76, PII 0004273720060900000010
    • P Wietzke-Braun AB Maouzi LB Manhardt H Bickeboller G Ramadori S Mihm 2006 Interferon regulatory factor-1 promoter polymorphism and the outcome of hepatitis C virus infection Eur J Gastroenterol Hepatol 18 991 997 16894313 10.1097/01.meg.0000224478.89545.76 1:CAS:528:DC%2BD28Xnsl2htLg%3D (Pubitemid 44213043)
    • (2006) European Journal of Gastroenterology and Hepatology , vol.18 , Issue.9 , pp. 991-997
    • Wietzke-Braun, P.1    Maouzi, A.B.2    Manhardt, L.B.3    Bickeboller, H.4    Ramadori, G.5    Mihm, S.6
  • 24
    • 79952214262 scopus 로고    scopus 로고
    • IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection
    • 21374656 10.1002/hep.24154 1:CAS:528:DC%2BC3MXkt1Clsbk%3D
    • A Moghaddam E Melum N Reinton H Ring-Larsen H Verbaan K Bjoro O Dalgard 2011 IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection Hepatology 53 746 754 21374656 10.1002/hep.24154 1:CAS:528:DC%2BC3MXkt1Clsbk%3D
    • (2011) Hepatology , vol.53 , pp. 746-754
    • Moghaddam, A.1    Melum, E.2    Reinton, N.3    Ring-Larsen, H.4    Verbaan, H.5    Bjoro, K.6    Dalgard, O.7
  • 25
    • 0031055840 scopus 로고    scopus 로고
    • Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype
    • DOI 10.1002/hep.510250340
    • S Mihm A Fayyazi H Hartmann G Ramadori 1997 Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype Hepatology 25 735 739 9049227 10.1002/hep.510250340 1:STN:280:DyaK2s3gtFCnsw%3D%3D (Pubitemid 27106462)
    • (1997) Hepatology , vol.25 , Issue.3 , pp. 735-739
    • Mihm, S.1    Fayyazi, A.2    Hartmann, H.3    Ramadori, G.4
  • 26
    • 0029682112 scopus 로고    scopus 로고
    • Preferential virological response to interferon-α(2a) in patients with chronic hepatitis C infected by virus genotype 3a and exhibiting a low γ-GT/ALT ratio
    • DOI 10.1007/BF02088246
    • S Mihm H Hartmann A Fayyazi G Ramadori 1996 Preferential virological response to interferon-alpha 2a in patients with chronic hepatitis C infected by virus genotype 3a and exhibiting a low gamma-GT/ALT ratio Dig Dis Sci 41 1256 1264 8654161 10.1007/BF02088246 1:STN:280:DyaK283lvVyrtw%3D%3D (Pubitemid 26227902)
    • (1996) Digestive Diseases and Sciences , vol.41 , Issue.6 , pp. 1256-1264
    • Mihm, S.1    Hartmann, H.2    Fayyazi, A.3    Ramadori, G.4
  • 27
    • 0028235641 scopus 로고
    • Classification of chronic hepatitis: Diagnosis, grading and staging
    • DOI 10.1016/0270-9139(94)90250-X
    • VJ Desmet M Gerber JH Hoofnagle M Manns PJ Scheuer 1994 Classification of chronic hepatitis: diagnosis, grading and staging Hepatology 19 1513 1520 8188183 10.1002/hep.1840190629 1:STN:280:DyaK2c3ksFWisw%3D%3D (Pubitemid 24166476)
    • (1994) Hepatology , vol.19 , Issue.6 , pp. 1513-1520
    • Desmet, V.J.1    Gerber, M.2    Hoofnagle, J.H.3    Manns, M.4    Scheuer, P.J.5
  • 28
    • 46249129460 scopus 로고    scopus 로고
    • Randomized comparison of 12 or 24 weeks of peginterferon α-2a and ribavirin in chronic hepatitis C virus genotype 2/3 infection
    • DOI 10.1002/hep.22253
    • M Lagging N Langeland C Pedersen M Farkkila MR Buhl K Morch AP Dhillon A Alsio K Hellstrand J Westin G Norkrans 2008 Randomized comparison of 12 or 24 weeks of peginterferon alpha-2a and ribavirin in chronic hepatitis C virus genotype 2/3 infection Hepatology 47 1837 1845 18454508 10.1002/hep.22253 1:CAS:528:DC%2BD1cXotVagtr4%3D (Pubitemid 351945551)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1837-1845
    • Lagging, M.1    Langeland, N.2    Pedersen, C.3    Farkkila, M.4    Buhl, M.R.5    Morch, K.6    Dhillon, A.P.7    Alsio, A.8    Hellstrand, K.9    Westin, J.10    Norkrans, G.11
  • 31
    • 79955148913 scopus 로고    scopus 로고
    • Efficacy of pegylated interferon-alpha2a monotherapy in Japanese children with chronic hepatitis C
    • 21518401 10.1111/j.1872-034X.2011.00789.x 1:CAS:528:DC%2BC3MXotFWhu78%3D
    • T Tsunoda A Inui Y Etani Y Kiyohara T Sugiura K Ito R Miyazawa I Nagata S Ida T Fujisawa 2011 Efficacy of pegylated interferon-alpha2a monotherapy in Japanese children with chronic hepatitis C Hepatol Res 41 399 404 21518401 10.1111/j.1872-034X.2011.00789.x 1:CAS:528:DC%2BC3MXotFWhu78%3D
    • (2011) Hepatol Res , vol.41 , pp. 399-404
    • Tsunoda, T.1    Inui, A.2    Etani, Y.3    Kiyohara, Y.4    Sugiura, T.5    Ito, K.6    Miyazawa, R.7    Nagata, I.8    Ida, S.9    Fujisawa, T.10
  • 32
    • 58349122475 scopus 로고    scopus 로고
    • Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C
    • 19144941 10.1056/NEJMoa0805062 1:CAS:528:DC%2BD1MXnsFGitA%3D%3D
    • M Rodriguez-Torres LJ Jeffers MY Sheikh L Rossaro V Ankoma-Sey FM Hamzeh P Martin 2009 Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C N Engl J Med 360 257 267 19144941 10.1056/NEJMoa0805062 1:CAS:528:DC%2BD1MXnsFGitA%3D%3D
    • (2009) N Engl J Med , vol.360 , pp. 257-267
    • Rodriguez-Torres, M.1    Jeffers, L.J.2    Sheikh, M.Y.3    Rossaro, L.4    Ankoma-Sey, V.5    Hamzeh, F.M.6    Martin, P.7
  • 33
    • 84984562129 scopus 로고    scopus 로고
    • Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: A multicenter, randomized controlled trial
    • 18834319 10.1086/592579 1:CAS:528:DC%2BD1cXhsVeqs7jP
    • CH Liu CJ Liu CL Lin CC Liang SJ Hsu SS Yang CS Hsu TC Tseng CC Wang MY Lai JH Chen PJ Chen DS Chen JH Kao 2008 Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial Clin Infect Dis 47 1260 1269 18834319 10.1086/592579 1:CAS:528:DC%2BD1cXhsVeqs7jP
    • (2008) Clin Infect Dis , vol.47 , pp. 1260-1269
    • Liu, C.H.1    Liu, C.J.2    Lin, C.L.3    Liang, C.C.4    Hsu, S.J.5    Yang, S.S.6    Hsu, C.S.7    Tseng, T.C.8    Wang, C.C.9    Lai, M.Y.10    Chen, J.H.11    Chen, P.J.12    Chen, D.S.13    Kao, J.H.14
  • 34
    • 0033001639 scopus 로고    scopus 로고
    • Ratio of serum γ-GT/ALT rather than ISDR variability is predictive for initial virological response to IFN-α in chronic HCV infection
    • DOI 10.1002/(SICI)1096-9071(199907)58: 3<227::AID-JMV7>3.0.CO;2-7
    • S Mihm M Monazahian S Grethe C Fechner G Ramadori R Thomssen 1999 Ratio of serum gamma-GT/ALT rather than ISDR variability is predictive for initial virological response to IFN-alpha in chronic HCV infection J Med Virol 58 227 234 10447417 10.1002/(SICI)1096-9071(199907)58:3<227::AID-JMV7>3.0.CO;2-7 1:CAS:528:DyaK1MXjvFKhur8%3D (Pubitemid 29278024)
    • (1999) Journal of Medical Virology , vol.58 , Issue.3 , pp. 227-234
    • Mihm, S.1    Monazahian, M.2    Grethe, S.3    Fechner, C.4    Ramadori, G.5    Thomssen, R.6
  • 36
    • 0036089296 scopus 로고    scopus 로고
    • High sustained response rate in patients with histologically mild (low grade and stage) chronic hepatitis C infection. A randomized, double blind, placebo controlled trial of interferon alpha-2b with and without ribavirin
    • DOI 10.1097/00042737-200206000-00007
    • HP Verbaan HE Widell TL Bondeson SC Lindgren 2002 High sustained response rate in patients with histologically mild (low grade and stage) chronic hepatitis C infection. A randomized, double blind, placebo controlled trial of interferon alpha-2b with and without ribavirin Eur J Gastroenterol Hepatol 14 627 633 12072596 10.1097/00042737-200206000-00007 1:CAS:528:DC%2BD38XlsF2js7s%3D (Pubitemid 34666641)
    • (2002) European Journal of Gastroenterology and Hepatology , vol.14 , Issue.6 , pp. 627-633
    • Verbaan, H.P.1    Widell, H.E.A.2    Bondeson, T.L.3    Lindgren, S.C.4
  • 41
    • 79953856071 scopus 로고    scopus 로고
    • Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin
    • 21145807 10.1016/j.jhep.2010.08.024 1:CAS:528:DC%2BC3MXkvFGhurg%3D
    • TM Scherzer H Hofer AF Staettermayer K Rutter S Beinhardt P Steindl-Munda H Kerschner HH Kessler P Ferenci 2011 Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin J Hepatol 54 866 871 21145807 10.1016/j.jhep.2010.08.024 1:CAS:528:DC%2BC3MXkvFGhurg%3D
    • (2011) J Hepatol , vol.54 , pp. 866-871
    • Scherzer, T.M.1    Hofer, H.2    Staettermayer, A.F.3    Rutter, K.4    Beinhardt, S.5    Steindl-Munda, P.6    Kerschner, H.7    Kessler, H.H.8    Ferenci, P.9
  • 42
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy
    • DOI 10.1126/science.282.5386.103
    • AU Neumann NP Lam H Dahari DR Gretch TE Wiley TJ Layden AS Perelson 1998 Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Science 282 103 107 9756471 10.1126/science.282.5386. 103 1:CAS:528:DyaK1cXmsFOjsLc%3D (Pubitemid 28471138)
    • (1998) Science , vol.282 , Issue.5386 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6    Perelson, A.S.7
  • 43
    • 0031009603 scopus 로고    scopus 로고
    • Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa
    • NP Lam AU Neumann DR Gretch TE Wiley AS Perelson TJ Layden 1997 Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa Hepatology 26 226 231 9214474 10.1002/hep.510260130 1:CAS:528: DyaK2sXkslagtbo%3D (Pubitemid 27280329)
    • (1997) Hepatology , vol.26 , Issue.1 , pp. 226-231
    • Lam, N.P.1    Neumann, A.U.2    Gretch, D.R.3    Wiley, T.E.4    Perelson, A.S.5    Layden, T.J.6
  • 45
    • 0036892371 scopus 로고    scopus 로고
    • Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: Therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors
    • DOI 10.1016/S0168-8278(02)00301-X, PII S016882780200301X
    • N Akuta F Suzuki A Tsubota Y Suzuki T Someya M Kobayashi S Saitoh Y Arase K Ikeda H Kumada 2002 Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors J Hepatol 37 831 836 12445425 10.1016/S0168-8278(02) 00301-X 1:CAS:528:DC%2BD38XoslCjtbs%3D (Pubitemid 35404223)
    • (2002) Journal of Hepatology , vol.37 , Issue.6 , pp. 831-836
    • Akuta, N.1    Suzuki, F.2    Tsubota, A.3    Suzuki, Y.4    Someya, T.5    Kobayashi, M.6    Saitoh, S.7    Arase, Y.8    Ikeda, K.9    Kumada, H.10
  • 46
    • 9144260228 scopus 로고    scopus 로고
    • High sustained virologic response rate after interferon monotherapy in Japanese hepatitis C patients with a low HCV RNA titer and/or HCV genotype 2: A prospective study
    • DOI 10.1159/000080876
    • O Yokosuka S Iwama N Suzuki M Takashi Y Hirai K Uchiumi M Kimura N Gotou S Hino A Hayasaka T Kanda S Kawai K Fukai F Imazeki H Saisho 2004 High sustained virologic response rate after interferon monotherapy in Japanese hepatitis C patients with a low HCV RNA titer and/or HCV genotype 2. A prospective study Intervirology 47 328 334 15564744 10.1159/000080876 1:CAS:528:DC%2BD2cXhtVagsbbK (Pubitemid 39541279)
    • (2004) Intervirology , vol.47 , Issue.6 , pp. 328-334
    • Yokosuka, O.1    Iwama, S.2    Suzuki, N.3    Takashi, M.4    Hirai, Y.5    Uchiumi, K.6    Kimura, M.7    Gotou, N.8    Hino, S.9    Hayasaka, A.10    Kanda, T.11    Kawai, S.12    Fukai, K.13    Imazeki, F.14    Saisho, H.15


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.