Effects of Deliberate Ingestion of Organophosphate or Paraquat on Brain Stem Auditory-Evoked Potentials

Journal of Medical Toxicology

Volumn 7, Issue 4, 2011, Pages 277-280

  Jayasinghe, Sudheera Sammanthi ^a,b   Pathirana, Kithsiri Dedduwa ^a  

^a UNIVERSITY OF RUHUNA   (Sri Lanka)

^b UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

Evoked potentials; Organophosphorus compounds; Paraquat; Suicide

Indexed keywords

ORGANOPHOSPHATE; PARAQUAT; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; HUMAN; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; OTOTOXICITY; SELF POISONING; SRI LANKA; TERTIARY HEALTH CARE;

ADULT; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; HUMANS; MALE; MIDDLE AGED; PARAQUAT; PHOSPHORIC ACID ESTERS;

EID: 82555172411     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-011-0173-3     Document Type: Article

References (17)

1. Jayarathnam J, Senevirathna RSDA, Copplestone JF (1982) Survey of pesticide poisoning in Sri Lanka. Bull World Health Organ 60: 615-619.
2. Jayarathnam J (1990) Acute pesticide poisoning: a major global health problem. World Health Stat Q 43: 139-144.
3. Gawarammana IB, Dawson AH (2010) Peripheral burning sensation: a novel clinical marker of poor prognosis and higher plasma-paraquat concentrations in paraquat poisoning. Clin Toxicol (Phila) 48: 347-349.
4. Bus JS, Gibson JE (1984) Paraquat: model for oxidant-initiated toxicity. Environ Health Perspect 55: 37-46.
5. Dandapani M, Zachariah A, Kavitha MR, Jeyaseelan L, Oommen A (2003) Oxidative damage in intermediate syndrome of acute organophosphorous poisoning. Indian J Med Res 117: 253-259.
6. Slotkin TFS, Frederic J, Seidler FJ (2009) Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Environ Health Perspect 117: 587-596.
7. Clerici WJ, Yang L (1996) Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res 101: 14-22.
8. Priuska EM, Schacht J (1995) Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 50: 1749-1752.
9. Harris KC, Bielefeld E, Hu BH, Henderson D (2006) Increased resistance to free radical damage induced by low-level sound conditioning. Hear Res 213: 118-129.
10. Ohlemiller KK, Wright JS, Dugan LL (1999) Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 4: 229-236.
11. Bielefeld EC, Hu BH, Harris KC, Henderson D (2005) Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide. Hear Res 207: 35-42.
12. Dassanayake T, Gawarammana IB, Weerasinghe V, Dissanayake PS, Pragaash S, Dawson A, Senanayake N (2009) Auditory event-related potential changes in chronic occupational exposure to organophosphate pesticides. Clin Neurophysiol 120: 1693-1698.
13. Kimura K, Yokoyama K, Sato H, Nordin RB, Naing L, Kimura S, Okabe S, Maeno T, Kobayashi Y, Kitamura F, Araki S (2005) Effects of pesticides on the peripheral and central nervous system in tobacco farmers in Malaysia: studies on peripheral nerve conduction, brain-evoked potentials and computerized posturography. Ind Health 43: 285-294.
14. Chen GH, Lin JL, Huang YK (2002) Combined methylprednisolone and dexamethasone therapy for paraquat poisoning. Crit Care Med 30: 2584-2587.
15. Lin JL, Leu ML, Liu YC, Chen GH (1999) A prospective clinical trial of pulse therapy with glucocorticoid and cyclophosphamide in moderate to severe paraquat-poisoned patients. Am J Respir Crit Care Med 159: 357-360.
16. Otto D, Hudnell K, Boyes W, Janssen R, Dyer R (1988) Electrophysiological measures of visual and auditory function as indices of neurotoxicity. Toxicology 49: 205-218.
17. Legatt AD, Arezzo JC, Vaughan HG (1988) The anatomic and physiologic bases of brain stem auditory evoked potentials. Neurol Clin 6: 681-704.