Low cost-effectiveness of CD3/CD20 immunostains for initial triage of lymphoid-rich effusions: An evidence-based review of the utility of these stains in selecting cases for full hematopathologic workup

Diagnostic Cytopathology

Volumn 40, Issue 7, 2012, Pages 565-569

  Walts, Ann E ^a   Marchevsky, Alberto M ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

CD20; CD3; lymphoid rich; lymphoma; pleural effusion

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN;

ADULT; AGED; ALGORITHM; ARTICLE; BLOOD CELL COUNT; CELL STRUCTURE; COST EFFECTIVENESS ANALYSIS; CYTOLOGY; DIAGNOSTIC PROCEDURE; EMERGENCY HEALTH SERVICE; EVIDENCE BASED PRACTICE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKEMIA; LYMPHOCYTOMA; LYMPHOCYTOSIS; LYMPHOID CELL; LYMPHOMA; MEDICAL RECORD REVIEW; PLEURA EFFUSION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ALGORITHMS; ANTIGENS, CD20; ANTIGENS, CD3; COLORING AGENTS; COST-BENEFIT ANALYSIS; EVIDENCE-BASED MEDICINE; HEMATOLOGIC DISEASES; HUMANS; IMMUNOLOGIC TESTS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTE COUNT; LYMPHOCYTES; LYMPHOCYTOSIS; PLEURAL EFFUSION, MALIGNANT; RETROSPECTIVE STUDIES;

EID: 82555167817     PISSN: 87551039     EISSN: 10970339     Source Type: Journal    
DOI: 10.1002/dc.21578     Document Type: Article

References (24)

1. Potrykus AM, Steinmann G, Stein E, Mertelsmann R,. T and B-cell responses in patients with malignant pleural effusions. Br J Cancer 1981; 43: 471-477.
2. Morrone N, Gama e Silva Volpe VL, Dourado AM, Mitre F, Coletta EN,. Bilateral pleural effusion due to mediastinal fibrosis induced by radiotherapy. Chest 1993; 104: 1276-1278.
3. Alexandrakis MG, Passam FH, Kyriakou DS, Bouros D,. Pleural effusions in hematologic malignancies. Chest 2004; 125: 1546-1555.
4. Hirsch A, Ruffie P, Nebut M, Bignon J, Chretien J,. Pleural effusion: Laboratory tests in 300 cases. Thorax 1979; 34: 106-112.
5. Prabhudesai PP, Mahashur AA, Mehta N, Ajay R,. Exudative pleural effusions in patients over forty years of age-An analysis of seventy-six patients. J Postgrad Med 1993; 39: 190-193.
6. Valdes L, Alvarez D, Valle JM, Pose A, San Jose E,. The etiology of pleural effusions in an area with high incidence of tuberculosis. Chest 1996; 109: 158-162.
7. Johnston WW,. The malignant pleural effusion. A review of cytopathologic diagnoses of 584 specimens from 472 consecutive patients. Cancer 1985; 56: 905-909.
8. Westfall DE, Fan X, Marchevsky AM,. Evidence-based guidelines to optimize the selection of antibody panels in cytopathology: Pleural effusions with malignant epithelioid cells. Diagn Cytopathol 2010; 38: 9-14.
9. Marchevsky AM,. The application of special technologies in anatomic pathology: Is it consistent with the principles of evidence-based medicine? Semin Diagn Pathol 2005; 22: 156-166.
10. Marchevsky AM, Wick MR,. Evidence-based guidelines for the utilization of immunostains in diagnostic pathology: Pulmonary adenocarcinoma versus mesothelioma. Appl Immunohistochem Mol Morphol 2007; 15: 140-144.
11. www.ascp.org.
12. www.uscap.org.
13. www.cytopathology.org.
14. www.cap.org.
15. Cellerin L, Marcq M, Sagan C, Chailleux E,. Malignant pleural effusion as the presenting site of cancer: Comparison with metastatic pleural effusions from known cancers. Rev Mal Respir 2008; 25: 1104-1109.
16. Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpesvirus. Blood 1996; 88: 645-656.
17. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM,. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDs-related body-cavity -based lymphomas. N Engl J Med 1995; 332: 1186-1191.
18. Dhingra KK, Singhal N, Nigam S, Jain S,. Unsuspected multiple myeloma presenting as bilateral pleural effusion-A cytological diagnosis. Cytojournal 2007; 4: 17.
19. Van den Berge M, Tinga CJ, Bieger R,. A 73-year old man with chronic lymphocytic leukaemia and a haemorrhagic pleural effusion. Ann Haematol 2001; 80: 183-186.
20. Wang J, Chen C, Lau S, et al. CD3-positive large B-cell lymphoma. Am J Surg Pathol 2009; 33: 505-512.
21. Cumiskey J, Noonan S, Cummins R, et al. T Cell lymphoma co-expressing CD20. Diagn Histopathol 2010; 16: 111-113.
22. Mohrman RL, Arber DA,. CD20-Positive peripheral T-cell lymphoma: Report of a case after nodular sclerosis Hodgkin's disease and review of the literature. Mod Pathol 2000; 13: 1244-1252.
23. Zukerberg LR, Collins AB, Ferry JA, Harris NL,. Coexpression of CD15 and CD20 by Reed-Sternberg cells in Hodgkin's disease. Am J Pathol 1991; 139: 475-483.
24. Tzankov A, Zimpfer A, Pehrs AC, et al. Expression of B-cell markers in classical Hodgkin lymphoma: A tissue microarray analysis of 330 cases. Mod Pathol 2003; 16: 1141-1147.