Minimal-invasive magnetic heating of tumors does not alter intra-tumoral nanoparticle accumulation, allowing for repeated therapy sessions: An in vivo study in mice

Nanotechnology

Volumn 22, Issue 50, 2011, Pages

  Kettering, Melanie ^a   Richter, Heike ^b   Wiekhorst, Frank ^b   Bremer Streck, Sibylle ^a   Trahms, Lutz ^b   Kaiser, Werner Alois ^a   Hilger, Ingrid ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b PHYSIKALISCH TECHNISCHE BUNDESANSTALT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE AREA; ADVERSE EFFECT; BIODISTRIBUTIONS; CANCER RESEARCH; HEALTHY TISSUES; HEATING TREATMENTS; IN-VIVO; INTERNAL ORGANS; LONG TERM MONITORING; MAGNETIC HEATING; MAGNETORELAXOMETRY; MULTI-CHANNEL; SINGLE-CHANNEL; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; TARGET CELLS; TARGET REGIONS; THERMAL ABLATION;

CELL DEATH; HEATING; HYPERTHERMIA THERAPY; IRON OXIDES; IRON RESEARCH; MAMMALS; NANOPARTICLES; SUPERPARAMAGNETISM; TUMORS;

NANOMAGNETICS;

FERUMOXYTOL; MAGNETITE NANOPARTICLE;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CHEMISTRY; CYTOCHEMISTRY; EXPERIMENTAL NEOPLASM; FEMALE; HUMAN; HYPERTHERMIC THERAPY; LIVER; MAGNETOMETRY; METABOLISM; METHODOLOGY; MOUSE; MOUSE MUTANT; RADIATION EXPOSURE; SPLEEN; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FEMALE; FERUMOXYTOL; HISTOCYTOCHEMISTRY; HUMANS; HYPERTHERMIA, INDUCED; LIVER; MAGNETITE NANOPARTICLES; MAGNETOMETRY; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; SPLEEN; TISSUE DISTRIBUTION;

EID: 82455206257     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/22/50/505102     Document Type: Article

References (25)

1. van der Zee J 2002 Heating the patient: a promising approach? Ann. Oncol. 13 1173-84
2. Stauffer P R 2005 Evolving technology for thermal therapy of cancer Int. J. Hyperthermia 21 731-44 (Pubitemid 41807100)
3. Jordan A et al 2006 The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma J. Neurooncol. 78 7-14 (Pubitemid 43786652)
4. Diederich C J 2005 Thermal ablation and high-temperature thermal therapy: overview of technology and clinical implementation Int. J. Hyperthermia 21 745-53 (Pubitemid 41807101)
5. Hilger I, Rapp A, Greulich K O and Kaiser W A 2005 Assessment of DNA damage in target tumor cells after thermoablation in mice Radiology 237 500-6 (Pubitemid 41509437)
6. Hilger I, Hiergeist R, Hergt R, Winnefeld K, Schubert H and Kaiser W A 2002 Thermal ablation of tumors using magnetic nanoparticles: an in vivo feasibility study Invest. Radiol. 37 580-6
7. Hergt R, Hiergeist R, Zeisberger M, Glöckl G, Weitschies W, Ramirez L P, Hilger I and Kaiser W A 2004 Enhancement of AC-losses of magnetic nanoparticles for heating applications J. Magn. Magn. Mater. 280 358-68
8. Kettering M et al 2007 Magnetic nanoparticles as bimodal tools in magnetically induced labelling and magnetic heating of tumour cells: an in vitro study Nanotechnology 18 175101
9. Johannsen M, Gneveckow U, Taymoorian K, Thiesen B, Waldofner N, Scholz R, Jung K, Jordan A, Wust P and Loening S A 2007 Morbidity and quality of life during thermotherapy using magnetic nanoparticles in locally recurrent prostate cancer: results of a prospective phase I trial Int. J. Hyperthermia 23 315-23 (Pubitemid 46860598)
10. 3 nanoparticles combined with magnetic fluid hyperthermia on cultured liver cancer cells and xenograft liver cancers J. Nanosci. Nanotechnol. 5 1185-92 (Pubitemid 44502127)
11. Maier-Hauff K et al 2007 Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme J. Neurooncol. 81 53-60 (Pubitemid 44963989)
12. Shubayev V I, Pisanic T R II and Jin S 2009 Magnetic nanoparticles for theragnostics Adv. Drug Deliv. Rev. 61 467-77
13. Richter H, Kettering M, Wiekhorst F, Steinhoff U, Hilger I and Trahms L 2010 Magnetorelaxometry for localization and quantification of magnetic nanoparticles for thermal ablation studies Phys. Med. Biol. 55 623-33
14. Richter H, Kettering M, Wiekhorst F, Kosch O, Hilger I and Trahms L 2010 Multichannel magnetorelaxometry in vivo monitoring of magnetic nanoparticle quantity for thermal ablation studies AIP Conf. Proc. 1311 255-60
15. Hilger I, Andra W, Hergt R, Hiergeist R, Schubert H and Kaiser W A 2001 Electromagnetic heating of breast tumors in interventional radiology: in vitro and in vivo studies in human cadavers and mice Radiology 218 570-5 (Pubitemid 32121077)
16. Schnabel A, Burghoff M, Hartwig S, Petsche F, Steinhoff U, Drung D and Koch H 2004 A sensor configuration for a 304 SQUID vector magnetometer Neurol. Clin. Neurophysiol. 2004 70
17. Eberbeck D, Wiekhorst F, Steinhoff U and Trahms L 2006 Aggregation behaviour of magnetic nanoparticle suspensions investigated by magnetorelaxometry J. Phys.: Condens. Matter 18 S2829-46 (Pubitemid 44523004)
18. Kötitz R, Fannin P C and Trahms L 1995 Time domain study of Brownian and Neél relaxation in ferrofluids J. Magn. Magn. Mater. 149 42-6
19. Wiekhorst F, Seliger C, Jurgons R, Steinhoff U, Eberbeck D, Trahms L and Alexiou C 2006 Quantification of magnetic nanoparticles by magnetorelaxometry and comparison to histology after magnetic drug targeting J. Nanosci. Nanotechnol. 6 3222-5 (Pubitemid 44580004)
20. Thiel F, Schnabel A, Knappe-Grüneberg S, Stollfu D and Burghoff M 2007 Demagnetization of magnetically shielded rooms Rev. Sci. Instrum. 78 035106
21. Hilger I, Hergt R and Kaiser W A 2005 Use of magnetic nanoparticle heating in the treatment of breast cancer IEE Proc. Nanobiotechnol. 152 33-9 (Pubitemid 40453794)
22. Tseng H Y, Lee G B, Lee C Y, Shih Y H and Lin X Z 2009 Localised heating of tumours utilising injectable magnetic nanoparticles for hyperthermia cancer therapy IET Nanobiotechnol. 3 46-54
23. Bankert R B, Hess S D and Egilmez N K 2002 SCID mouse models to study human cancer pathogenesis and approaches to therapy: potential, limitations, and future directions Front. Biosci. 7 c44-62
24. Eberbeck D, Kettering M, Bergemann C, Zirpel P, Hilger I and Trahms L 2010 Quantification of the aggregation of magnetic nanoparticles with different polymeric coatings in fetal calf serum J. Phys. D: Appl. Phys. 43 405002
25. Abe S et al 2009 Biodistribution imaging of magnetic particles in mice: x-ray scanning analytical microscopy and magnetic resonance imaging Biomed. Mater. Eng. 19 213-20