Ribavirin pharmacokinetics and interleukin 28B plus cytochrome P450 27B1 single-nucleotide polymorphisms as predictors of response to pegylated interferon/ribavirin treatment in patients infected with hepatitis C virus genotype 1/4

Hepatology

Volumn 54, Issue 6, 2011, Pages 2279-

  D'Avolio, Antonio ^a   Ciancio, Alessia ^a   Siccardi, Marco ^a   Baietto, Lorena ^a   Simiele, Marco ^a   Cariti, Giuseppe ^a   Calcagno, Andrea ^a   Smedile, Antonina ^a   Cusato, Jessica ^a   Bonora, Stefano ^a   Rizzetto, Mario ^a   Di Perri, Giovanni ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; CYTOCHROME P450; CYTOCHROME P450 27B1; INTERLEUKIN 28B; PEGINTERFERON; RIBAVIRIN; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE;

GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LETTER; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; FEMALE; GENETICS; MALE; NOTE; VIROLOGY; VITAMIN D DEFICIENCY;

FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERLEUKINS; MALE; VITAMIN D DEFICIENCY;

EID: 82455167754     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24636     Document Type: Letter

References (5)

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2. Orton SM, Morris AP, Herrera BM, Ramagopalan SV, Lincoln MR, Chao MJ, et al. Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis. Am J Clin Nutr 2008; 88: 441-447.
3. Aparicio E, Parera M, Franco S, Perez-Alvarez N, Tural C, Clotet B, et al. IL28B SNP rs8099917 is strongly associated with pegylated interferon-alpha and ribavirin therapy treatment failure in HCV/HIV-1 coinfected patients. PLoS One 2010; 5: e13771.
4. Aguilar Marucco D, Gonzalez de Requena D, Bonora S, Tettoni C, Bonasso M, De Blasi T, et al. The use of trough ribavirin concentration to predict sustained virological response and haematological toxicity in HIV/HCV-co-infected patients treated with ribavirin and pegylated interferon. J Antimicrob Chemother 2008; 61: 919-924.
5. van Vlerken LG, van Oijen MG, van Erpecum KJ. Ribavirin concentration is a more important predictor of sustained viral response than anemia in hepatitis C patients. Gastroenterology 2011; 140: 1693-1694.