Chloroquine self-treatment and clinical outcome of cerebral malaria in children

Clinical and Experimental Immunology

Volumn 108, Issue 2, 1997, Pages 279-283

  Picot, S ^a   Nkwelle Akede, A ^b   Chaulet, J F ^c   Tetanye, E ^b   Ringwald, P ^d   Prevosto J M ^c   Boudin, C ^d   Ambroise Thomas, P ^a  

^a HÔPITAL MICHALLON   (France)

^b UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^c HIA Desgenettes   (France)

^d Laboratoire de Recherche sur le Paludisme Yaounde   (Cameroon)

Author keywords

chloroquine resistance; malaria; Plasmodium falciparum; self medication; tumour necrosis factor alpha

Indexed keywords

AMODIAQUINE; AMPICILLIN; CHLORAMPHENICOL; CHLOROQUINE; DEETHYLCHLOROQUINE; PENICILLIN G; PENICILLIN V; QUININE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; BRAIN MALARIA; CAMEROON; CHILD; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE COURSE; ENDEMIC DISEASE; FEMALE; HUMAN; HUMAN CELL; INFANT; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MENINGITIS; ORAL DRUG ADMINISTRATION; PARASITEMIA; PLASMODIUM FALCIPARUM; PNEUMONIA; PRIORITY JOURNAL; SELF MEDICATION; TREATMENT OUTCOME;

EID: 8244255926     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.d01-996.x     Document Type: Article

References (19)

1. World Health Organization. World malaria situation in 1993. Wkly Epidem Rec 1996; 3:17-22.
2. Foster SDF. The distribution and use of antimalarial drugs - not a pretty picture. In: Targett GAT, ed. Malaria: waiting for the vaccine. Chichester: John Wiley 1991:123-39.
3. Deming M, Gayibor A, Murphy K, Jones TS, Karsa T. The home treatment of febrile children with anti-malarial drugs in Togo. Bull WHO 1989; 67:695-700.
4. Greenberg AE, Ntumbanzondo M, Ntula N, Mawa L, Howell J, Davachi F. Hospital-based surveillance of malaria-related morbidity and mortality in Kinshsa, Zaire. Bull WHO 1989; 67:189-96.
5. World Health Organization. Practical chemotherapy of malaria: report of a WHO scientific group. Geneva: Technical Report Series 1990: 805.
6. Grau GE, Piguet PF, Vassalli P, Lambert PH. Tumor necrosis factor and other cytokines in cerebral malaria: experimental and clinical data. Immunol Rev 1989; 112:49-70.
7. Kwiatkowski D, Hill AV, Sambou I et al. TNF concentration in fatal cerebral, non-fatal cerebral and uncomplicated P. falciparum malaria. Lancet 1990; 336:1201-4.
8. Picot S, Peyron F, Vuillez JP, Polack B, Ambroise-Thomas P. Chloroquine inhibits TNF production by human macrophages in vitro. J Infect Dis 1991; 164:830.
9. Picot S, Peyron F, Donadille A, Vuillez JP, Barbe G, Ambroise-Thomas P. Chloroquine induced inhibition of the production of TNF, but not of IL6, is affected by disruption of iron metabolism. Immunol 1993; 80:127-33.
10. Louis JP, Hengy C, Louis FJ. Proposal for a new therapeutic strategy for simple P. falciparum malaria attacks in Cameroon. Trop Med Parasitol 1992; 43:118-20.
11. Warrell DA, Molyneux ME, Beales PF. Severe and complicated malaria. Trans Roy Soc Trop Med Hyg 1990; 84:1-65.
12. Tetanye E, Yondo D, Bernard-Bonnin AC et al. Initial treatment of bacterial meningitis in Yaounde, Cameroon: theoretical benefits of the ampicillin-chloramphenicol combination vs. chloramphenicol alone. Ann Trop Paed 1990; 10:285-91.
13. Chaulet JF, Grelaud G, Bellemin-Magninot P, Mounier C, Brazier JL. Simultaneous determination of chloroquine, proguanil and their metabolites in human biological fluids by high-performance liquid chromatography. J Pharmaceut Biomed Anal 1994; 1:111-7.
14. Le Bras J, Deloron P. In vitro study of drug sensitivity of P. falciparum: an evaluation of a new semi-microtest. Am J Trop Med Hyg 1983; 32:447-51.
15. Grau GE, Taylor TE, Molyneux ME et al. Tumor necrosis factor and disease severity in children with falciparum malaria. New Engl J Med 1989; 320:1586-91.
16. Ertel W, Morrison MH, Ayala A, Chaudry IH. Chloroquine attenuates hemorrhagic shock-induced suppression of kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. Blood 1991; 78:1781-8.
17. Wetstey JCFM. Inhibition of tumour necrosis factor production by antimalarial drugs used in cerebral malaria. Trans Roy Soc Trop Med Hyg 1995; 89:700.
18. Kwiatkowski D, Bate C. Inhibition of tumour necrosis factor (TNF) production by antimalarial drugs used in cerebral malaria. Trans Roy Soc Trop Med Hyg 1995; 89:215-6.
19. Kirby GC, Warhurst DC. The use of chloroquine in combination with arteminisinin derivatives. Trans Roy Soc Trop Med Hyg 1995; 89:699.