Structure of the complex of an Fab fragment of a neutralizing antibody with foot-and-mouth disease virus: Positioning of a highly mobile antigenic loop

EMBO Journal

Volumn 16, Issue 7, 1997, Pages 1492-1500

  Hewat, Elizabeth A ^a   Verdaguer, Nuria ^b   Fita, Ignacio ^b   Blakemore, Wendy ^c   Brookes, Sharon ^c   King, Andrew ^c   Newman, John ^c   Domingo, Esteban ^d   Mateu, Mauricio G ^d   Stuart, David I ^e,f  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^c INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antigenicity; Cryo electron microscopy; Crystallography; Foot and mouth disease virus; Virus Fab structure

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; INTEGRIN; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; RECEPTOR; VIRUS PROTEIN;

ANTIGEN ANTIBODY COMPLEX; ANTIGENICITY; ARTICLE; CRYOELECTRON MICROSCOPY; FOOT AND MOUTH DISEASE VIRUS; IMMUNOGLOBULIN STRUCTURE; NONHUMAN; PRIORITY JOURNAL; SEROTYPING; VIRUS CAPSID; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; APHTHOVIRUS; BINDING SITES; CAPSID; CAPSID PROTEINS; COMPUTER GRAPHICS; FREEZING; IMMUNOGLOBULIN FAB FRAGMENTS; INTEGRINS; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

EID: 8244249460     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.7.1492     Document Type: Article

References (49)

1. Acharya,R., Fry,E., Stuart,D., Fox,G., Rowlands,D. and Brown,F. (1989) The three dimensional structure of foot-and-mouth disease virus at 2.8 Å resolution, Nature, 337, 709-716.
2. Baker,T.S. and Cheng,R.H. (1996) A model based approach for determining orientations of biological macromolecules imaged by cryoelectron microscopy. J. Struct. Biol., 116, 120-130.
3. Barlow,D.J., Edwards,M.S. and Thornton,J.M. (1986) Continuous and discontinuous antigenic determinants. Nature, 322, 747-748.
4. Baxt,B. and Bachrach,H.L. (1980) Early interactions of foot-and-mouth disease virus with cultured cells. Virology, 104, 42-55.
5. Bittle,J.L., Houghten,R.A., Alexander,H., Shinnick,T.M., Sutcliffer,J.G., Lerner,R.A., Rowlands,D. and Brown,F. (1982) Protection against foot-and-mouth disease virus by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature, 298, 30-33.
6. Brown,F. (1992). New approaches to vaccination against foot-and-mouth disease virus. Vaccine, 10, 1022-1026.
7. Brünger,A.T. (1993) XPLOR Manual. Version 3.1. Yale University, New Haven, CT.
8. Crowther,R.A. (1971) Procedures for three-dimensional reconstruction of spherical viruses by Fourier synthesis from electron micrographs. Phil. Trans. R. Soc. Lond. Ser. B, 261, 221-230.
9. Curry,S. et al. (1992) Crystallisation and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus. J. Mol. Biol., 228, 1263-1268.
10. Curry,S. et al. (1996) Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and immunogenicity. Structure, 4, 135-145.
11. Dimmock,N.J. (1993) Neutralization of Animal Viruses. Springer-Verlag, Berlin.
12. Domingo,E., Mateu,M.G., Martinez,M.A., Dopazo,J. and Moya,A. (1990) Genetic variability and antigenic diversity of foot-and-mouth disease virus. In Kursta,K.E., Marusyk,R.G., Murphy,F.A. and Van Regenmortel,M.H.V. (eds), Applied Virology Research. Plenum Press, New York, Vol. 3, pp. 223-226.
13. Fuller,S.D. (1987) The T=4 envelope of sinbis virus is organised by complementary interactions with a T=3 icosahedral capsid. Cell, 48, 923-934.
14. Fuller,S.D., Butcher,S.J., Cheng,R.H. and Baker,T.S. (1996) Three-dimensional reconstruction of icosahedral particles. The uncommon line. J. Struct. Biol., 116, 48-55.
15. Ghiara,J.B., Stura,E.A., Stanfield,R.L., Profy,A.T. and Wilson,I.A. (1994) Crystal structure of the principal neutralization site of HIV-1. Science, 264, 82-85.
16. Hewat,E.A. and Blaas,D. (1996) Structure of a neutralizing antibody bound bivalently to human rhinovirus 2. EMBO J., 15, 1515-1523.
17. Hewat,E.A., Booth,T.F. Loudon,P.T. and Roy,P. (1992a) Three dimensional reconstruction of baculovirus expressed bluetongue virus core-like particles by cryo-electron microscopy. Virology, 189, 10-20.
18. Hewat,E.A., Booth,T.F. and Roy,P. (1992b) Structure of bluetongue virus particles by cryoelectron microscopy. J. Struct. Biol., 109, 61-69.
19. Hogle,J.M. (1993) The viral canyon. Curr. Biol., 3, 278-281.
20. Jones,T.A., Zou,Y.J., Cowan,S.W. and Kjeldgaard,M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr., A47, 110-119.
21. Krebs,O., Ahl.,R., Straube,O.C. and Marquardt,O. (1993) Amino acid changes outside the G-H loop of capsid protein VP1 of type O foot-and-mouth disease virus confer resistance to neutralization by antipeptide G-H serum. Vaccine, 11, 359-362.
22. Lea,S. et al. (1994) The structure and antigenicity of serotype C foot-and-mouth disease virus. Structure, 2, 123-139.
23. 1 and a laboratory antigenic variant, G67. Structure, 3, 571-580.
24. Logan,D. et al. (1993) Structure of a major immunogenic site on foot-and-mouth disease virus. Nature, 362, 566-568.
25. Mason,P.W., Rieder,E. and Baxt,B. (1994) RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor but can be bypassed by an antibody-dependent enhancement pathway. Proc. Natl Acad. Sci. USA, 91, 1932-1936.
26. Mateu,M.G. (1995) Antibody recognition of picornaviruses and escape from neutralization: a structural view. Virus Res., 38, 1-24.
27. Mateu,M.G., Rocha,E., Vicente,O., Vayreda,F., Navalpotro,C., Pedroso,E., Enjuanes,L., Giralt,E. and Domingo,E. (1987) Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease. Virus Res., 8, 261-274.
28. Mateu,M.G. et al. (1994) Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by a very limited sequence variation at several antigenic sites. J. Virol., 68, 1407-1411.
29. Novella,I.S., Borrego,B., Mateu,M.G., Domingo,E., Giralt,E. and Andreu,D. (1993) Use of substituted and tandem-repeated peptides to probe the relevance of the highly conserved RGD tripeptide in the immune response against foot-and-mouth disease virus. FEBS Lett., 330, 253-259.
30. Olson,N.H., Kolatkar,P.R., Oliveira,M.A., Cheng,R.H., Greve,J.M., McClelland,A., Baker,T.S. and Rossmann,M.G. (1993) Structure of a human rhinovirus complexed with its receptor molecule. Proc. Natl Acad. Sci. USA, 90, 507-511.
31. Parry,N., Fox,G., Rowlands,D., Brown,F., Fry,E., Acharya,R., Logan,D. and Stuart,D. (1990) Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus. Nature, 347, 569-572.
32. Pfaff,E., Mussgay,M, Bohm,H.O., Schultz,G.E. and Shaller,H. (1982) Antibodies against a preselected peptide recognize and neutralize foot-and-mouth disease virus. EMBO J., 1, 869-874.
33. Rossman,M.G. et al. (1985) Structure of a common cold virus and functional relationship to other picornaviruses. Nature, 317, 145-153.
34. Rousel,A. and Cambillau,C. (1991) TURBO. In Silicon Graphics Directory: Mountain View, CA.
35. Rueckert,R.R. (1990) Picornaviridae. In Fields,B.N. and Knope,D.M. (eds), Virology. Raven Press, New York, pp. 507-548.
36. Smith,T.J. et al. (1993a) Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody. J. Virol., 67, 1148-1158.
37. Smith,T.J., Olson,N.H., Cheng,R.H., Chase,E.S. and Baker,T.S. (1993b) Structure of a human rhinovirus-bivalently bound antibody complex: implications for viral neutralization and antibody flexibility. Proc. Natl Acad. Sci. USA, 90, 7015-7018.
38. Smith,T.J., Chase,E.S., Schmidt,T.J., Olson,N.H. and Baker,T.S. (1996) Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon. Nature, 383, 350-354.
39. Strassheim,M.L., Gruenberg,A., Veijalainen,P., Sgro,J.Y. and Parish,C.R. (1994) Two dominant neutralizing antigenic determinants of canine parvovirus are found on the three-fold spike of the virus capsid. Virology, 198, 175-184.
40. Stromaier,K., Franze,R. and Ada,K.H. (1982) Location and characterization of the antigenic portion of the FMDV immunizing protein. J. Gen. Virol., 59, 295-306.
41. Stuart,D.I. (1993) Viruses. Curr. Opin. Struct. Biol., 3, 167-174.
42. Tormo,J., Blaas,D., Parry,N.R., Rowlands,D., Stuart,D. and Fita,I. (1994) Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2. EMBO J., 13, 2247-2256.
43. Vasquez,D., Denoya,C.D., LaTorre,J.L. and Palma,E.L. (1979) Structure of foot-and-mouth disease virus capsid. Virology, 97, 195-200.
44. Verdaguer,N., Mateu,M.G., Bravo,J., Tormo,J., Giralt,E., Andreu,D., Domingo,E. and Fita,I. (1994) Crystallization and preliminary X-ray difraction of a monoclonal antibody Fab fragment against foot-and-mouth disease virus and of its complex with the main antigenic site peptide. Proteins, 18, 201-203.
45. Verdaguer,N., Mateu,M.G., Andreu,D., Giralt,E., Domingo,E. and Fita,I. (1995) Structure of the major antigenic loop of foot-and-mouth disease virus complexed to anti-virus neutralizing antibody. Direct involvement of Arg-Gly-Asp in the interaction. EMBO J., 14, 1690-1696.
46. Verdaguer,N., Mateu,M.G., Bravo,J.E., Domingo,E. and Fita,I. (1996) Induced pocket to accommodate the cell atachment Arg-Gly-Asp motif in a neutralizing antibody against foot-and-mouth disease virus. J. Mol. Biol., 256, 364-376.
47. Wang,G., Porta,C. Chen,Z., Baker,T.S. and Johnson,J.E. (1992) Identification of a Fab interaction footprint site on an icosahedral virus by cryoelectron microscopy and X-ray diffraction. Nature, 355, 275-278.
48. Wikoff,W.R., Wang,G., Parrish,C.R., Cheng,R.H., Strassheim,M.L., Baker,T.S. and Rossmann,M. (1994) The structure of a neutralized virus: canine parvovirus complexed with neutralizing antibody fragment. Structure, 2, 595-607.
49. Wein,M.W., Filman,D.J., Stura,E.A., Guillot,S., Delpeyroux,F., Crainic,R. and Hogle,J.M. (1995) Structure of the complex between the Fab fragment of a neutralizing antibody for poliovirus type 1 and its viral epitope. Nature Struct. Biol., 2, 232-243.