Atypical pneumonia in the Nordic countries: Aetiology and clinical results of a trial comparing fleroxacin and doxycycline

Journal of Antimicrobial Chemotherapy

Volumn 39, Issue 4, 1997, Pages 499-508

  Norrby, Ragnar ^a   Ahonen, A ^b   Koskinen, R ^b   Rantanen, P ^b   Billheden, J ^c   Brathen G ^d   Briem, H ^e   Cronberg, S ^a   Haidl, S ^a   Elmrud, H ^f   Banke, S ^f   Forsberg, P ^g   Hanninen P ^h   Hedstrom S A ⁱ   Erntell, M ⁱ   Lahdevirta J ^j   Hakulinen, A ^j   Siikamaki H ^j   Lindahl, L ^k   Neringer, R ^l   Eklund, P O ^l   Norrby, S R ^a   Schliamser, S E ^a   Permin, H ^m   Salmi, H A ⁿ   Gerlin Piira, L ⁿ   Klemets, P ⁿ   Lindholm, L ⁿ   Pollonen M P ⁿ   Rosengren, L M ⁿ   Sinasalo, J P ⁿ   Takal, A ⁿ   Yliapalosaari, P ⁿ   Seefeldt Nielsen, T ^o   Tarp, B ^o   Soderstrom C ^p   Tauris, P ^q   Tikkinen, J ^r   Walstad, R A ^s   Thomassen, T ^s   more..

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Laakso Hospital   (Finland)

^c UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^d Bardu Hospital   (Norway)

^e Reykjavik City Hospital   (Iceland)

^f CENTRAL HOSPITAL   (Sweden)

^g Växjä Central Hospital   (Sweden)

^h TURKU CITY HOSPITAL   (Finland)

ⁱ HALMSTAD HOSPITAL   (Sweden)

^j Aurora Hospital   (Finland)

^k HELSINGBORG HOSPITAL   (Sweden)

^l CENTRAL HOSPITAL   (Sweden)

^m Rigshospitalet   (Denmark)

ⁿ CENTRAL MILITARY HOSPITAL   (Finland)

^o AARHUS UNIVERSITY HOSPITAL   (Denmark)

^p Central Hospital of Kalmar   (Sweden)

^q HERNING HOSPITAL   (Denmark)

^r Military Hospital   (Finland)

^s TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; FLEROXACIN;

ADULT; ANTIMICROBIAL ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CHLAMYDIACEAE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; INSOMNIA; LEGIONELLA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MYCOPLASMA; NAUSEA; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; STREPTOCOCCUS PNEUMONIAE; TASTE DISORDER; THORAX PAIN; VERTIGO; VIRUS INFECTION; VIRUS PNEUMONIA; VOMITING;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CHLAMYDIA INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; DENMARK; DOUBLE-BLIND METHOD; DOXYCYCLINE; FINLAND; FLEROXACIN; HUMANS; ICELAND; LEGIONELLOSIS; LONGITUDINAL STUDIES; MYCOPLASMA PNEUMONIAE; NORWAY; PNEUMONIA, BACTERIAL; SLEEP INITIATION AND MAINTENANCE DISORDERS; SWEDEN;

EID: 8244247106     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Johnson, D. H. & Cunha, B. A. (1993). Atypical pneumonias. Clinical and extrapulmonary features of Chlamydia, Mycoplasma, and Legionella infections. Postgraduate Medicine 93, 69-72, 75-6, 79-82.
2. Hammerschlag, M. R., Qumei, K. K. & Roblin, P. M. (1992) In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae. Antimicrobial Agents and Chemotherapy 36, 1573-4.
3. Havlichek, D., Saravolatz, L, & Pohlod, D. (1987). Effect of quinolones and other antimicrobial agents on cell-associated Legionella pneumophila. Antimicrobial Agents and Chemotherapy 31, 1529-34.
4. Agacfidan, A., Moncada, J. & Schachter, J. (1993). In vitro activity of azithromycin (CP-62,993) against Chlamydia trachomatis and Chlamydia pneumoniae. Antimicrobial Agents and Chemotherapy 37, 1746-8.
5. Renaudin, H. & Bebear, C. (1992). Activité in vitro de la sparfloxacine sur les mycoplasmes. Pathologie Biologie 40, 450-4.
6. Kenny, G. E. & Cartwright, F. D. (1991). Susceptibility of Mycopiasma pneumoniae to several new quinolones, tetracycline, and erythromycin. Antimicrobial Agents and Chemotherapy 35, 587-9.
7. Hammerschlag, M. R., Hyman, C. L. & Roblin, P. M. (1992). In vitro activities of five quinolones against Chlamydia pneumoniae. Antimicrobial Agents and Chemotherapy 36, 682-3.
8. Edelstein, P. H. & Edelstein, M. A. (1992). In vitro activity of RO 23-9424 against clinical isolates of Legionella species. Antimicrobial Agents and Chemotherapy 36, 2559-61.
9. Edelstein, P. H., Edelstein, M. A. & Holzknecht, B. (1992). In vitro activities of fleroxacin against clinical isolates of Legionella spp., its pharmacokinetics in guinea pigs, and use to treat guinea pigs with L. pneumophila pneumonia. Antimicrobial Agents and Chemotherapy 36, 2387-91.
10. Wise, R., Honeybourne, D., Andrews, J. M. & Ashby, J. P. (1988). The penetration of fleroxacin into bronchial mucosa. Journal of Antimicrobial Chemotherapy 22, 203-6.
11. Paganoni, R., Herzog, C., Braunsteiner, A. & Hohl, P. (1988). Fleroxacin: in-vitro activity worldwide against 20,807 clinical isolates and comparison to ciprofloxacin and norfloxacin. Journal of Antimicrobial Chemotherapy 22, Suppl. D, 3-17.
12. Food and Drug Administration. (1989). 'COSTART, Coding Symbols for Thesaurus of Adverse Reaction Terms, 3rd edn. US Food and Drug Administration, Rockeville, MD.
13. Ukkonen, P., Hovi, T., von Bonsdorff, C. H., Saikku, P. & Penttinen, K. (1984). Age-specific prevalence of complement-fixing antibodies to sixteen viral antigens: a computer analysis of 58,500 patients covering a period of eight years. Journal of Medical Virology 13, 131-48.
14. Ekman, M. R., Leinonen, M., Syrjälä, H., Linnanmäki, E., Kujala, P. & Saikku, P. (1993). Evaluation of serological methods in the diagnosis of Chlamydia pneumoniae pneumonia during an epidemic in Finland. European Journal of Clinical Microbiology & Infectious Diseases 12, 756-60.
15. Wang, S. P. & Grayston, J. T. (1970). Immunologic relationship between genital TRIG, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. American Journal of Ophthalmology 70, 367-74.
16. Wang, S. P. & Grayston, J. T. (1986). Microimmunofluorescence serological studies with the TWAR organism. In Chlamydial Infections (Oriel, J. D. Ridgway, G., Schachter, J., Taylor-Robinson, D. & Ward, M., Eds), pp. 329-32. Cambridge University Press, Cambridge.
17. Jalonen, E., Taira, S., Paton, J. C., Kerttula, Y., Soumalainen, P. & Leinonen, M. (1990). Pneumolysin, produced in Bacillus subtills as antigen in enzyme immunoassay for etiological diagnosis of pneumococcal pneumonia. Serodiagnosis and Immunotherapy in Infectious Disease 4, 459-68.
18. Wilkinson, H. W., Cruce, D. D. & Broome, C. V. (1981). Validation of Legionella pneumophila indirect immunofluorescence assay with epidemic sera. Journal of Clinical Microbiology 13, 139-46.
19. Wilkinson, H. W., Reingold, A. L., Brake, B. J., McGiboney, D. L., Gorman, G. W. & Broome, C. V. (1983). Reactivity of serum from patients with suspected legionellosis against 29 antigens of Legionellaceae and Legionella-llke organisms by indirect immunofluorescence assay. Journal of Infectious Diseases 147, 23-31.
20. Kenny, G. E., Kaiser, G. G., Cooney, M. K. & Foy, H. M. (1990). Diagnosis of Mycoplasma pneumoniae pneumonia: sensitivities and specificities of serology with lipid antigen and isolation of the organism on soy peptone medium for identification of infections. Journal of Clinical Microbiology 28, 2087-93.
21. Denny, F. W., Clyde, W. A. & Glezen, W. P. (1971). Mycoplasma pneumoniae disease: clinical spectrum, pathophysiology, epidemiology, and control. Journal of Infectious Diseases 123, 74-92.
22. Schönwald, S., Barsic, B., Klinar, I. & Gunjaca, M. (1994). Three-day azithromycin compared with ten-day roxithromycin treatment of atypical pneumonia. Scandinavian Journal of Infectious Diseases 26, 706-10.
23. Bohte, R., van't Wout, J. W., Labatto, S., Blusse van Oud-Alblas, A., Boekhout, M., Nauta, E. H. et al. (1995). Efficacy and safety of azithromycin versus benzylpenicillin or erythromycin in community-acquired pneumonia. European Journal of Clinical Microbiology & Infectious Diseases 14, 182-7.
24. Cunha, B. A. (1995). The antibiotic treatment of community-acquired, atypical, and nosocomial pneumonias. Medical Clinics of North America 79, 581-97.
25. Lowe, N. J., Fakouhi, T. D., Stern, R. S., Bourget, T., Roniker, B. & Swabb, E. A. (1994). Photoreactions with a fluoroquinolone antimicrobial: evening versus morning dosing. Clinical Pharmacology and Therapeutics 56, 587-91.