T cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): Crossreactivity with group I allergens of different grasses

Advances in Experimental Medicine and Biology

Volumn 409, Issue , 1996, Pages 141-146

  Schenk, Siegfried ^a   Breiteneder, Heimo ^a   Susani, Markus ^b   Najafian, Nader ^a   Laffer, Sylvia ^a   Duchêne, Michael ^a   Valenta, Rudolf ^a   Fischer, Gottfried ^c   Scheiner, Otto ^a   Kraft, Dietrich ^a   Ebner, Christof ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Institute of Molecular Biology Salzburg   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS REACTING ANTIGEN; CYTOKINE; EPITOPE; IMMUNOGLOBULIN E; POLLEN ANTIGEN; T LYMPHOCYTE RECEPTOR;

CLINICAL ARTICLE; CONFERENCE PAPER; CROSS REACTION; GRASS POLLEN; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; POLLEN ALLERGY; PRIORITY JOURNAL; RADIOALLERGOSORBENT TEST; SKIN TEST; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

PHLEUM PRATENSE; POACEAE;

EID: 8244246436     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5855-2_19     Document Type: Conference Paper

References (20)

1. Laffer S, Valenta R, Vrtala S et al. Recombinant major allergen Phl p I from timothy grass (Phleum pratense) inhibits IgE-binding to multiple isoforms of group I grass pollen allergens from eight different grass species. J Allergy Clin Immunol 1994 (in press).
2. Perez M, Isihoka GY, Walker LE, Chestnut RW. cDNA cloning and Immunological Characterization of the Rye Grass Allergen Lol p I. J Biol Chem 1990;265:16210-5.
3. Griffith IJ, Smith PM, Pollock J, Theerakalpisut P, et al. Cloning and sequencing of Lol p I, the major allergenic protein of rye-grass pollen. FEBS Lett 1991;279:210-5.
4. Mosmann TR, Coffman RL. Heterogeneity of cytokine secretion patterns and function of T helper cells. Adv Immunol 1989;46:111-47.
5. Wierenga AE, Snoek M, DeGroot C et al. Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 1990;144:4651-6.
6. Romagnani S. Human Th1 and Th2: Doubt no more. Immunol Today 1991;12:256-7.
7. Spiegelberg HL, Beck L, Stevenson D, Ishioka GY. Recognition of T Cell Epitopes and Lymphokine Secretion by Rye Grass Allergen Lolium perenne I-Specific Human T Cell Clones. J Immunol 1994;152:4706-11.
8. Fischer GF, Pickl WF, Faé I, et al. Association between IgE-response against Bet v 1, the major allergen of birch pollen, and HLA-DRB alleles. Hum Immunol 1991;33:259-65.
9. Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, Scheiner O, Kraft D. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa . Allergy 1989;44:385-95.
10. Ebner C, Szépfalusi Z., Ferreira F, et al. Identification of multiple T cell epitopes on Bet v 1, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 1993;150:1047-54.
11. Ebner C, Schenk, S, Szépfalusi, Z, et al. Multiple T cell specificities for Bet v 1, the major birch pollen allergen, within single individuals. Studies using specific T cell clones and overlapping peptides. Eur J Immunol 1993;23:1523-7.
12. Van Neerven RJJ, Van de Pol MM, Van Milligen FJ, Jansen HM, Aalberse RC, Kapsenberg M. Characterization of Cat Dander-Specific T Lymphocytes from Atopic Patients. J Immunol 1994;152:4203-10.
13. Hoyne GF, O'Hehir RE, Wraith DC, Thomas WR, Lamb JR. Inhibition of T cell and antibody response to the house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med 1993;178:1783-8.
14. Del Prete GF, Maggi E, Parronchi P, et al. IL-4 is an essential factor for the IgE-synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-8.
15. Norman PS, Winkenwerder WL, Lichtenstein LM. Immunotherapy of hay fever with antigen E: comparison with whole pollen extracts and placebos. J Allergy 1968;42:93-99.
16. Bousquet J, Becker WM, Hejjaoudi A, et al. Differences in clinical and immunological reactivity of patients allergic to grass pollen and to multiple-pollen species. II. Efficacy of a double blind, placebo controlled, specific immunotherapy with standardized extracts. J Allergy Clin Immunol 1991;88:43-53.
17. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993;178:2123-30.
18. Litwin A, Pesce AJ, Fischer T, Michael M, Michael JG. Regulation of the human response to ragweed pollen by immunotherapy. A controlled trial compasring the effect of immunosuppressive peptic fragments of short ragweed with standard treatment. Clin Exp Allergy 1991;21:457-65.
19. Briner TJ, Kuo MC, Keating, KM, Rogers BL, Greenstein JL. Peripheral T cell tolerance induced in naive mice and primed mice by subcutaneous injection of peptides from the cat major allergen Fel d 1. Proc Natl Acad Sci USA 1993;90:7608-12.
20. Wallner BP, Getter M.L. Immunotherapy with T-cell-reactive peptides derived from allergens. Allergy 1994;49:302-8.