Quantitation of the anti-HIV alkaloids michellamines A and B by high pressure liquid chromatography

Phytochemical Analysis

Volumn 8, Issue 3, 1997, Pages 120-123

  McCloud, Thomas G ^a   Britt, John R ^a   Cartner, Laura K ^a   Pearl, Kay C ^a,c   Majadly, Fathy D ^a   Muschik, Gary M ^a   Klueh, Paul A ^a,f   Cragg, Gordon M ^b   Thomas, Duncan W ^c   Jato, Johnson G ^d   Simon, James E ^e  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c University of Yaounde I ^*  (United States)

^d UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^e PURDUE UNIVERSITY   (United States)

^f WASHINGTON UNIVERSITY   (United States)

Author keywords

Alkaloids; Ancistrocladus; Anti HIV activity; High pressure liquid chromatography; Michellamines

Indexed keywords

DISEASES; HIGH PRESSURE LIQUID CHROMATOGRAPHY; METABOLITES; VIRUSES;

ANALYTICAL METHOD; ANCISTROCLADUS; ANTI-HUMAN IMMUNODEFICIENCY VIRUS ACTIVITY; DIMERIC ALKALOIDS; HUMAN IMMUNODEFICIENCY VIRUS; IN-VITRO; MICHELLAMINE; NEW SPECIES;

ALKALOIDS;

ALKALOID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MICHELLAMINE A; MICHELLAMINE B; PLANT EXTRACT;

ANALYTIC METHOD; ANTIVIRAL ACTIVITY; ARTICLE; BIOMASS; CONTROLLED STUDY; DRUG ANALYSIS; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF;

EID: 8244243236     PISSN: 09580344     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1565(199705)8:3<120::AID-PCA345>3.0.CO;2-4     Document Type: Article

References (12)

1. Boyd, M. R., Hallock, Y. F., Cardellina II, J. H., Manfredi, K. P., Blunt, J. W., McMahon, J. B., Buckheit, R. W., Bringmann, G., Schaffer, M. and Cragg, G. M. (1994). Anti-HIV michellamines from Ancistrocladus korupensis, J. Med. Chem. 37, 1740-1745.
2. Bringmann, G., Zagst, R., Reuscher, H. and Assi, L. A. (1992). Acetogenic isoquinoline alkaloids Part 34: ancistrobrevine B, the first naphthylisoquinoline alkaloid with a 5,8′-coupling site, and related compounds from Ancistrocladus abbreviatus. Phytochemistry 31, 4011-4014.
3. Bringmann, G., Zagst R., Schaffer, M., Hallock, Y. F., Cardellina II, J. H. and Boyd, M. R. (1993). The absolute configuration of michellamine B, a dimeric anti-HIV-active naphthylisoquinoline alkaloid. Angew. Chem. Intl. Ed. Engl. 32, 1190-1191.
4. Chan, K. C., Majadly, F., McCloud, T. G., Muschik, G. M., Issaq, H. J. and Snader, K. M. (1994). Micellar electrokinetic chromatography of the anti-human immunodeficiency virus (HIV) agent michellamine B with absorption and laser-induced fluorescence detection. Electrophoresis, 15, 1310-1315.
5. Cragg, G. M., Boyd, M. R., Cardellina II, J. H., Newman, D. J., Snader, K. M. and McCloud, T. G. (1994). Ethnobotany and the Search for New Drugs, Ciba Foundation Symposium Vol. 185, pp. 178-196. John Wiley, Chichester.
6. Hallock, Y. F., Manfredi, K. P., Blunt, J. E., Cardellina II, J. H., Schaffer, M., Gulden, K-P., Bringmann, G., Lee, A. Y., Clardy, J. and Francios, G. (1994). Korupenamines A-D, novel antimalarial alkaloids from Ancistrocladus korupensis. J. Org. Chem. 59, 6349-6355.
7. Manfredi, K. P., Blunt, J. W., Cardellina II, J. H., McMahon, J. B., Pannell, L. L., Cragg, G. M. and Boyd, M. R. (1991). Novel alkaloids from the tropical plant Ancistrocladus abbreviatus inhibit cell killing by HIV-1 and HIV-2. J. Med. Chem. 34, 3402-3405.
8. Simon, J. E., Jato, J., Symonds, P., Thomas, D., Gereau, R., Alkire, B., Jato, E. and McCloud, T. G. (1995). Feasibility studies on the cultivation of the Cameroon plant, Ancistrocladus korupensis. First Progress Report to the National Cancer Institute, Purdue University, West Lafayette, IN.
9. Simon, J. E., Jato, J. G., Thomas, D. W., Symonds, R, Alkire, B. H., McCloud, T. G., Cragg, G. M., Morales, M. R., Foster, P. F., Miller, J. S. and Gereau, R. E. (1996). Investigations on Ancistrocladus korupensis: A promising source of michellamine B from Cameroon. J. Soc. Econom. Bot. (submitted).
10. Supko, J. G. and Malspeis, L. (1994). Determination of michellamine B in biological fluids by high performance liquid chromatography with fluorescence detection. Anal. Biochem. 216, 52-60.
11. Thomas, D. W. and Gereau, R. E. (1993) Ancistrocladus korupensis (Ancistrocladaceae): a new species of liana from Cameroon. Novon 3, 494-498.
12. Weislow, O. S., Kiser, R., Fine, D. L., Bader, J., Shoemaker, R. H. and Boyd, M. R. (1989). New soluble-formazan assay for HIV-1 cytopathic effects: Application to high-flux screening of synthetic and natural products for AIDS-antiviral activity. J. Natl. Cancer Inst. 81, 577-586.