Dual hormonal replacement therapy with insulin and recombinant human insulin-like growth factor (IGF)-I in insulin-dependent diabetes mellitus: Effects on the growth hormone/IGF/IGF-binding protein system

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 4, 1997, Pages 1181-1187

  Thrailkill, Kathryn ^a,d   Quattrin, Teresa ^b   Baker, Lester ^c   Litton, Jean ^a   Dwigun, Karen ^b   Rearson, Melissa ^c   Poppenheimer, Mary ^f   Kotlovker, Debbie ^f   Giltinan, David ^f   Gesundheit, Neil ^e   Martha Jr , Paul ^f  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF BUFFALO   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e Menlo Park and VIVUS   (United States)

^f GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOSYLATED HEMOGLOBIN; GROWTH HORMONE; HEMOGLOBIN A1C; INSULIN; PLACEBO; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3;

ADOLESCENT; ARTICLE; BLOOD GLUCOSE MONITORING; CHILD; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; LONG TERM CARE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ADOLESCENT; CHILD; DIABETES MELLITUS, TYPE 1; DRUG THERAPY, COMBINATION; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MALE; RECOMBINANT PROTEINS; SOMATOMEDINS;

EID: 8244233164     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.4.1181     Document Type: Article

References (53)

1. Hayford JT, Danney MM, Hendrix JA, Thompson RG. 1980 Integrated concentration of growth hormone in juvenile-onset diabetes. Diabetes. 29:391-398.
2. Asplin CM, Faria AC, Carlson EC, et al. 1988 Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 69:239-245.
3. Schaper NC. 1990 Growth hormone in Type I diabetic and healthy man. Acta Endocrinol (Copenh). 122:1-47.
4. Lanes R, Recker B, Fort P, Lefshetz F. 1985 Impaired somatomedin generation test in children with insulin-dependent diabetes mellitus. Diabetes. 43:156-160.
5. Tan K, Baxter RC. 1986 Serum insulin-like growth factor I levels in adult diabetic patients: the effect of age. J Clin Endocrinol Metab. 63:651-655.
6. Taylor AM, Dunger DB, Grant DB, Preece MA. 1988 Somatomedin-C/IGF-I measured by radioimmunoassay and somatomedin bioactivity in adolescents with insulin-dependent diabetes compared with puberty matched controls. Diabetes Res. 9:177-181.
7. Batch JA, Baxter RC, Werther G. 1991 Abnormal regulation of insulin-like growth factor binding proteins in adolescents with insulin-dependent diabetes. J Clin Endocrinol Metab. 73:964-968.
8. Crosby SR, Tsigos C, Anderson CD, Gordon C, Young RJ, White A. 1992 Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy. Diabetologia. 35:868-872.
9. Suikkari AM, Koivisto VA, Rutanen EM, Yki-Järvinen H, Karonen SL, Seppälä M. 1988 Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein. J Clin Endocrinol Metab. 66:266-272.
10. Wang M, Wilson DM, Lee PDK. 1989 Serum levels of 25 kDa insulin-like growth factor binding protein in children with insulin-dependent diabetes mellitus. In: Drop SLS, Hintz RL (eds) Insulin-like Growth Factor Binding Proteins. Elsevier Science Publishers; Amsterdam, 39-44.
11. Daughaday WH, Trivedi B, Andrews BA. 1987 The ontogeny of serum GH binding in man: a possible indicator of hepatic GH receptor development. J Clin Endocrinol Metab. 65:1072-1074.
12. Menon RK, Arslanian S, May B, Cutfield WS, Sperling MA. 1992 Diminished growth hormone-binding protein in children with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 74:934-938.
13. Holl RW, Siegler B, Scherbaum WA, Heinze E. 1993 The serum growth hormone-binding protein is reduced in young patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 76:165-167.
14. Ooi GT, Orlowski CC, Brown AL, Becker RE, Unterman TG, Rechler MM. 1990 Different tissue distribution and hormonal regulation of messenger RNAs encoding rat insulin-like growth factor-binding proteins-1 and -2. Mol Endocrinol. 4:321-328.
15. Villafuerte BC, Goldstein S, Robertson DG, Pao C-I, Murphy LJ, Phillips LS. 1992 Molecular regulation of IGFBP-1 in hepatocyte primary culture. Diabetes. 41:835-842.
16. Bereket A, Lang CH, Blethen SL, et al. 1995 Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 80:1312-1317.
17. Rieu M, Binoux M. 1985 Serum levels of insulin-like growth factor (IGF) and IGF binding protein in insulin-dependent diabetics during an episode of severe metabolic decompensation and the recovery phase. J Clin Endocrinol Metab. 60:781-785.
18. Amiel SA, Sherwin RS, Hintz RL, Gertner JM, Press CM, Tamborlane WF. 1984 Effect of diabetes and its control on insulin-like growth factors in the young subject with type I diabetes. Diabetes. 33:1175-1179.
19. Strasser-Vogel B, Blum WF, Past R, et al. 1995 Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, -2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment. J Clin Endocrinol Metab. 80:1207-1213.
20. Clayton KL, Holly JMP, Carlsson LMS, et al. 1994 Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus. Clin Endocrinol (Oxf). 41:517-524.
21. Shishko PI, Dreval AV, Abugova IA, Zarjarny IU, Goncharov VC. 1994 Insulin-like growth factors and binding proteins in patients with recent-onset type 1 (insulin dependent) diabetes mellitus: influence of diabetes control and intraportal insulin infusion. Diab Res Clin Pract. 25:1-12.
22. Quattrin T, Thrailkill K, Baker L, Litton J, Dwigun K, Rearson M, Poppenheimer M, Giltinan D, Kotlovker D, Gesundheit N, Martha Jr, P. 1997 Dual hormonal replacement with insulin and recombinant human insulin-like growth factor I in insulin dependent diabetes mellitus: effects on glycemic control, IGF-I levels and safety profile. Diabetes Care. 20:374-380.
23. Liu F, Hintz RL, Khare A, DiAugustine RP, Powell DR, Lee PDK. 1994 Immunoblot studies of the IGF related acid-labile subunit. J Clin Endocrinol Metab. 79:1883-1886.
24. Lee PD, Conover CA, Powell DR. 1993 Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med. 204:4-29.
25. Baxter RC. 1994 Insulin-like growth factor binding proteins in the human circulation: a review. Horm Res. 42:140-144.
26. Savage MO, Blum, WF, Ranke MB, et al. 1993 Clinical features and endocrine status in patients with growth hormone insensitivity (Laron Syndrome). J Clin Endocrinol Metab. 77:1465-1471.
27. Lyall A, Innes JA. 1935 Diabetes and the pituitary gland: a case of diabetes with intercurrent pituitary lesion and concomitant improvement in diabetes. Lancet. 1:318-319.
28. Houssay BA, Biasotti A. 1930 La diabetes pancreatica de los perros hipofiseoprivos. Rev Soc Argent Biol. 6:251-296.
29. Campbell PJ, Bolli GB, Cryer PE, Gerich JE. 1985 Pathogenesis of the dawn phenomenon in patients with insulin-dependent diabetes mellitus. Accelerated glucose production and impaired glucose utilization due to nocturnal surges in growth hormone secretion. N Engl J Med. 312:1473-1479.
30. Block C, Clemens P, Sperling M. 1987 Puberty decreases insulin sensitivity. J Pediatr. 10:481-487.
31. Landau D, Chin E, Bondy C, et al. 1995 Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Endocrinology. 136:1835-1842.
32. Meyer-Schwickerath R, Pfeiffer A, Blum WF, et al. 1993 Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye diseases. Studies in nondiabetic and diabetic subjects. J Clin Invest. 92:2620-2625.
33. Cheetham TD, Jones J, Taylor AM, Holly J, Mathews DR, Dunger DB. 1993 The effects of recombinant insulin-like growth factor I administration on growth hormone levels and insulin requirements in adolescents with type I (insulin-dependent) diabetes mellitus. Diabetologia. 36:678-81.
34. Bach MA, Chin E, Bondy CA. 1994 The effects of subcutaneous insulin-like growth factor-I infusion in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 79:1040-045.
35. Wilson KF, Fielder, PJ, Guevara-Aguirre J, et al. 1995 Long-term effects of insulin-like growth factor (IGF)-I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency. Clin Endocrinol (Oxf). 42:399-407.
36. Blum WF, Hall K, Ranke MB, Wilton P. 1993 Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I. Kabi Pharmacia Study Group on Insulin-like Growth Factor I Treatment in Growth Hormone Insensitivity Syndromes. Acta Paediatr Suppl. 391:15-19.
37. Hizuka N, Takano K, Asakawa K, et al. 1991 Single se administration of insulin-like growth actor I (IGF-I) in normal men. Adv Exp Med Biol. 293:105-112.
38. Young SCJ, Underwood LE, Celniker A, Clemmons DR. 1992 Effects of recombinant insulin-like growth factor-I (IGF-I) and growth hormone on serum IGF binding proteins in calorically restricted adults. J Clin Endocrinol Metab. 75:603-608.
39. Morrow LA, O'Brien MB, Moller DE, Flier JS, Moses AC. 1994 Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the Type A syndrome of severe insulin resistance. J Clin Endocrinol Metab. 79:205-210.
40. Kuzuya H, Matsuura N, Sakamoto M, et al. 1993 Trial of insulin-like growth factor I therapy for patients with extreme insulin resistance syndromes. Diabetes. 42:696-705.
41. Zapf J, Schmid C, Guler HP, et al. 1990 Regulation of binding proteins for insulin-like growth factors (IGF) in humans: increased expression of IGF binding protein 2 during IGF-I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia. J Clin Invest. 86:952-961.
42. Smith JA, Nam TJ, Underwood LE, Busby WH, Celnicker A, Clemmons DR. 1993 Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. J Clin Endocrinol Metab. 77:1294-1299.
43. Rajkumar K, Barron D, Lewitt MS, Murphy LJ. 1995 Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice. Endocrinology. 136:4029-4034.
44. Lewitt MS, Denyer GS, Cooney GJ, Baxter RC. 1991 Insulin-like growth factor-binding protein-1 modulates blood glucose levels. Endocrinology. 129:2254-2265.
45. Flyvbjerg A, Bornfeldt KE, Marchall SM, Arnquist HJ, Orskov H. 1990 Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats. Diabetologia. 33:334-338.
46. Phillip M, Werner H, Palese T, et al. 1994 Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats. J Mol Endocrinol. 12:215-224.
47. Thrailkill KM, Clemmons DR, Busby, Jr, WH, Handwerger S. 1990 Differential regulation of insulin-like growth factor binding protein secretion from human decidual cells by IGF-I, insulin and relaxin. J Clin Invest. 86:878-883.
48. Dor J, Costritsci N, Pariente C, et al. 1992 Insulin-like growth factor-I and follicle stimulating hormone suppress insulin-like growth factor binding protein-1 secretion by human granulosa-luteal cells. J Clin Endocrinol Metab. 75:969-971.
49. Ishii DN, Lupien SB. 1995 Insulin-like growth factors protect against diabetic neuropathy: effects on sensory nerve regeneration in rats. J Neurosci Res. 40:138-144.
50. Osterby R, Seyer-Hansen K, Gunderson HJG, Lundbaek K. 1978 Growth hormone enhances basement membrane thickening in experimental diabetes. A preliminary report. Diabetologia. 15:487-489.
51. Wright AD, Kohner EM, Oakley NW, Hartog M, Joplin GF, Fraser TM. 1969 Serum GH levels and response of diabetic retinopathy to pituitary ablation. Br Med J. 2:343-348.
52. Lundbaek K, Malmros R, Anderson HC, et al. 1969 Hypophysectomy for diabetic angiopathy: a controlled clinical trial. In: Goldberg MF, Fine S (eds) Symposium on the Treatment of Diabetic Retinopathy. 219-311.
53. Passa P, Rousselie F, Gauville C, Canivet J. 1977 Retinopathy and plasma growth hormone levels in idiopathic hemochromatosis with diabetes. Diabetes. 26:113-120.