Mycophenolate mofetil added to immunosuppression after liver transplantation - First results

Transplant International

Volumn 10, Issue 3, 1997, Pages 223-228

  Klupp, J ^a   Bechstein, W O ^a   Platz, K P ^a   Keck, H ^a   Lemmens, H P ^a   Knoop, M ^a   Langrehr, J M ^a   Neuhaus, R ^a   Pratschke, J ^a   Neuhaus, P ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Immunosuppressive agents; Liver transplantation; Mycophenolate, mofetil

Indexed keywords

CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DEATH; DRUG TOXICITY; FEMALE; GRAFT REJECTION; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LEUKOPENIA; LIVER FUNCTION; LIVER TOXICITY; LIVER TRANSPLANTATION; MAINTENANCE THERAPY; MALE; MULTIPLE ORGAN FAILURE; NEPHROTOXICITY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ACUTE DISEASE; ADULT; CHRONIC DISEASE; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; PRODRUGS; TACROLIMUS;

EID: 8244231266     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001470050046     Document Type: Article

References (28)

1. Allison AC, Eugui EM (1993) Immunosuppressive and other effects of mycophenolic acid and an ester prodrug. mycophenolate mofetil. Immunol Rev 136: 5-28
2. Allison AC, Eugui EM (1993) Mycophenolate mofetil, a rational designed immunosuppressive drug. Clin Transplantation 7: 96-112
3. Allison AC, Eugui EM (1994) Preferential suppression of lymphocyte proliferation by mycophenolic acid and predicted long-term effects of mycophenolate mofetil in transplantation. Transplant Proc 26: 3205-3210
4. Allison AC, Eugui EM, Sollinger HW (1993) Mycophenolate Mofetil (RS-61 443): mechanisms of action and effects in transplantation. Transplant Rev 7: 129-139
5. Bechstein WO, Schilling M, Steele DM, Hullett DA, Sollinger HW (1993) RS-61443/cyclosporine combination therapy prolongs canine liver allograft survival. Transplant Proc 25: 702-703
6. Ensley RD, Bristow MR, Olsen SL, Taylor DO, Hammond EH, O' Connell J, Dunn D, Osburn L, Jones KW, Kauffman RS, Gay WA, Renlund DG (1993) The use of mycophenolate mofetil (RS-61 443) in human heart transplant recipients. Transplantation 56: 75-82
7. Epinette WW, Parker CM, Jones EL, Greist MC (1987) Mycophenolic acid for psoriasis. J Am Acad Dermatol 17: 962-971
8. European Mycophenolate Mofetil Cooperative Study Group (1995) Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345: 1321-1325
9. Freise CE, Hebert M, Osorio RW, Nikolai B, Lake JR, Kauffmann RS, Ascher NL, Roberts JP (1993) Maintenance immunosuppression with prednisone and RS-61 443 alone following liver transplantation. Transplant Proc 25: 1758
10. Gonwa TA (1996) Mycophenolate mofetil for maintenance therapy in kidney transplantation. Clin Transplant 10: 128-130
11. Hebert M, Ascher N, Lake J, Emond J, Linna TJ, Shah J, Nikolai B, Roberts J (1994) Mycophenolate mofetil for prophylaxis against rejection following orthotopic liver transplantation. XVth World Congress of the Transplantation Society, Kyoto, Japan
12. Kirklin JK, Bourge RC, Naftel DC, Morrow WR, Deierhoi MH, Kauffman RS, White-Williams C, Nomberg RI, Holman WL, Smith DCJ (1994) Treatment of recurrent heart rejection with mycophenolate mofetil (RS-61 443): initial clinical experience. J Heart Lung Transplant 13: 444-450
13. Klintmalm GB, Ascher NL, Busuttil RW, Deierhoi M, Gonwa TA, Kauffman R, McDiarmid S, Poplawski S, Sollinger H, Roberts J (1993) RS-61 443 for treatment-resistant human liver rejection. Transplant Proc 25: 697
14. McDiarmid SV (1996) Mycophenolate mofetil in liver transplantation. Clin Transplant 10: 140-145
15. McManus RP, O' Hair D, Komorowski R, Scott JP (1993) Immunosuppressant combinations in primate cardiac xenografts. A review. Ann N Y Acad Sci 696: 281-284
16. Morris RE, Hoyt EG, Murphy MP, Eugui EM, Allison AC (1990) Mycophenolic acid morpholinoethylester (RS-61 443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis. Transplant Proc 22: 1659
17. Mycophenolate Mofetil Renal Rejection Study Group (1996) Rescue therapy with mycophenolate mofetil. Clin Transplant 10: 131-135
18. O' Hair D, McManus RP, Komorowski R (1994) Inhibition of chronic vascular rejection in primate cardiac xenografts using mycophenolate mofetil. Ann Thorac Surg 58: 1311-1315
19. Platz KP, Bechstein WO, Eckhoff DE, Suzuki Y, Sollinger HW (1991) RS-61 443 reverses acute aliograft rejection in dogs. Surgery 110: 736-741
20. Platz KP, Eckhoff DE, Hullett DA, Sollinger HW (1991) Prolongation of dog renal allograft survival by RS-61443, a new, potent immunosuppressive agent. Transplant Proc 23: 497-498
21. Platz KP, Sollinger HW, Hullett DA, Eckhoff DE, Eugui EM, Allison AC (1991) RS-61 443 - a new, potent immunosuppressive agent. Transplantation 51: 27-31
22. Raisanen-Sokolowski A, Myllarniemi M, Hayry P (1994) Effect of mycophenolate mofetil on allograft arteriosclerosis (chronic rejection). Transplant Proc 26: 3225
23. Savoie A, Perpete C, Carpentier L, Joncas J, Alfieri C (1994) Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 83: 2715-2722
24. Sollinger HW for the U.S. Renal Transplant Mycophenolate Mofetil Study Group (1995) Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. Transplantation 60: 225-232
25. Sollinger HW (1996) From mice to man: the preclinical history of mycophenolate mofetil. Clin Transplant 10: 85-92
26. Sollinger HW, Beizer FO, Deierhoi MH, Diethelm AG, Gonwa TA, Kauffman RS, Klintmalm GB, McDiarmid SV, Roberts J, Rosenthal JT, Tomlanovich SJ (1992) RS-61 443 (mycophenolate mofetil). A multicenter study for refractory kidney transplant rejection. Ann Surg 216: 513-518
27. Steele DM, Hullett DA, Bechstein WO, Kowalski J, Smith LS, Kennedy E, Allison AC, Sollinger HW (1993) Effects of immunosuppressive therapy on the rat aortic allograft model. Transplant Proc 25: 754-755
28. Taylor DO, Ensley RD, Olsen SL, Dunn D, Renlund DG (1994) Mycophenolate mofetil (RS-61 443): preclinical, clinical, and three-year experience in heart transplantation. J Heart Lung Transplant 13: 571-582