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Volumn 314, Issue 1, 2012, Pages 63-72

EGFR and KRAS mutations and altered c-Met gene copy numbers in primary non-small cell lung cancer and associated stage N2 lymph node-metastasis

Author keywords

Epidermal growth factor receptor; Gene copy number; KRAS; MET; Mutation; Non small cell lung cancer

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GENOMIC DNA; K RAS PROTEIN; SCATTER FACTOR RECEPTOR;

EID: 82355191770     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.09.012     Document Type: Article
Times cited : (32)

References (33)
  • 6
    • 34249810645 scopus 로고    scopus 로고
    • KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Massarelli E., Varella-Garcia M., Tang X., Xavier A., Ozburn N., Liu D., Bekele B., Herbst R., Wistuba I. KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. Clin. Cancer Res. 2007, 13:2890-2896.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2890-2896
    • Massarelli, E.1    Varella-Garcia, M.2    Tang, X.3    Xavier, A.4    Ozburn, N.5    Liu, D.6    Bekele, B.7    Herbst, R.8    Wistuba, I.9
  • 7
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou H., Dahabreh I.J., Kanaloupiti D., Siannis F., Bafaloukos D., Kosmidis P., Papadimitriou C.A., Murray S. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008, 9:962-972.
    • (2008) Lancet Oncol. , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6    Papadimitriou, C.A.7    Murray, S.8
  • 8
    • 34249821410 scopus 로고    scopus 로고
    • An analysis of the prognostic and predictive importance of predictive importance of K-ras mutation status in the National Cancer Institute of Canada Clinical Trials Group BR.21 study of erlotinib versus placebo in the treatment of non-small cell lung cancer
    • Tsao M.S., Zhu C., Sakurada A. An analysis of the prognostic and predictive importance of predictive importance of K-ras mutation status in the National Cancer Institute of Canada Clinical Trials Group BR.21 study of erlotinib versus placebo in the treatment of non-small cell lung cancer. J. Clin. Oncol. 2006, 24:18S.
    • (2006) J. Clin. Oncol. , vol.24
    • Tsao, M.S.1    Zhu, C.2    Sakurada, A.3
  • 9
    • 68949201629 scopus 로고    scopus 로고
    • Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors
    • Gazdar A.F. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009, 28(Suppl 1):S24-31.
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1
    • Gazdar, A.F.1
  • 10
    • 34548009812 scopus 로고    scopus 로고
    • Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a nonsmall cell lung cancer cell line
    • Ogino A., Kitao H., Hirano S., Uchida A., Ishiai M., Kozuki T., Takigawa N., Takata M., Kiura K., Tanimoto M. Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a nonsmall cell lung cancer cell line. Cancer Res. 2007, 67:7807-7814.
    • (2007) Cancer Res. , vol.67 , pp. 7807-7814
    • Ogino, A.1    Kitao, H.2    Hirano, S.3    Uchida, A.4    Ishiai, M.5    Kozuki, T.6    Takigawa, N.7    Takata, M.8    Kiura, K.9    Tanimoto, M.10
  • 12
    • 77952519096 scopus 로고    scopus 로고
    • Clinical implications of MET gene copy number in lung cancer
    • Toschi L., Cappuzzo F. Clinical implications of MET gene copy number in lung cancer. Future Oncol. 2010, 6:239-247.
    • (2010) Future Oncol. , vol.6 , pp. 239-247
    • Toschi, L.1    Cappuzzo, F.2
  • 15
    • 0020616225 scopus 로고
    • Human tumor cell heterogeneity and metastasis
    • Spremulli E.N., Dexter D.L. Human tumor cell heterogeneity and metastasis. J. Clin. Oncol. 1983, 1:496-509.
    • (1983) J. Clin. Oncol. , vol.1 , pp. 496-509
    • Spremulli, E.N.1    Dexter, D.L.2
  • 16
    • 68049088934 scopus 로고    scopus 로고
    • EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
    • Schmid K., Oehl N., Wrba F., Pirker R., Pirker C., Filipits M. EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin. Cancer Res. 2009, 15:4554-4560.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4554-4560
    • Schmid, K.1    Oehl, N.2    Wrba, F.3    Pirker, R.4    Pirker, C.5    Filipits, M.6
  • 19
    • 63549140887 scopus 로고    scopus 로고
    • Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer
    • Gow C.H., Chang Y.L., Hsu Y.C., Tsai M.F., Wu C.T., Yu C.J., Yang C.H., Lee Y.C., Yang P.C., Shih J.Y. Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer. Ann. Oncol. 2009, 20:696-702.
    • (2009) Ann. Oncol. , vol.20 , pp. 696-702
    • Gow, C.H.1    Chang, Y.L.2    Hsu, Y.C.3    Tsai, M.F.4    Wu, C.T.5    Yu, C.J.6    Yang, C.H.7    Lee, Y.C.8    Yang, P.C.9    Shih, J.Y.10
  • 20
    • 68549111225 scopus 로고    scopus 로고
    • Discordance of molecular biomarkers associated with epidermal growth factor receptor pathway between primary tumors and lymph node metastasis in non-small cell lung cancer
    • Park S., Holmes-Tisch A.J., Cho E.Y., Shim Y.M., Kim J., Kim H.S., Lee J., Park Y.H., Ahn J.S., Park K., Jänne P.A., Ahn M.J. Discordance of molecular biomarkers associated with epidermal growth factor receptor pathway between primary tumors and lymph node metastasis in non-small cell lung cancer. J. Thorac. Oncol. 2009, 4:809-815.
    • (2009) J. Thorac. Oncol. , vol.4 , pp. 809-815
    • Park, S.1    Holmes-Tisch, A.J.2    Cho, E.Y.3    Shim, Y.M.4    Kim, J.5    Kim, H.S.6    Lee, J.7    Park, Y.H.8    Ahn, J.S.9    Park, K.10    Jänne, P.A.11    Ahn, M.J.12
  • 22
    • 77952822151 scopus 로고    scopus 로고
    • KRAS mutation status in primary nonsmall cell lung cancer and matched metastases
    • Cortot A.B., Italiano A., Burel-Vandenbos F., Martel-Planche G., Hainaut P. KRAS mutation status in primary nonsmall cell lung cancer and matched metastases. Cancer 2010, 116:2682-2687.
    • (2010) Cancer , vol.116 , pp. 2682-2687
    • Cortot, A.B.1    Italiano, A.2    Burel-Vandenbos, F.3    Martel-Planche, G.4    Hainaut, P.5
  • 23
    • 78049372832 scopus 로고    scopus 로고
    • Comparison of EGFR and KRAS status between primary non-small cell lung cancer and corresponding metastases: a systematic review and meta-analysis
    • Han C., Zou H., Ma J., Zhou Y., Zhao J. Comparison of EGFR and KRAS status between primary non-small cell lung cancer and corresponding metastases: a systematic review and meta-analysis. Zhongguo Fei Ai Za Zhi 2010, 13:882-891.
    • (2010) Zhongguo Fei Ai Za Zhi , vol.13 , pp. 882-891
    • Han, C.1    Zou, H.2    Ma, J.3    Zhou, Y.4    Zhao, J.5
  • 25
    • 34547616992 scopus 로고    scopus 로고
    • Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status
    • Badalian G., Barbai T., Rásó E., Derecskei K., Szendrôi M., Tímár J. Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status. Pathol. Oncol. Res. 2007, 13:99-104.
    • (2007) Pathol. Oncol. Res. , vol.13 , pp. 99-104
    • Badalian, G.1    Barbai, T.2    Rásó, E.3    Derecskei, K.4    Szendrôi, M.5    Tímár, J.6
  • 30
    • 70349464846 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway
    • Nguyen K.S., Kobayashi S., Costa D.B. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin. Cancer Res. 2009, 10:281-289.
    • (2009) Clin. Cancer Res. , vol.10 , pp. 281-289
    • Nguyen, K.S.1    Kobayashi, S.2    Costa, D.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.