NF-κB signaling pathway is inhibited by heat shock independently of active transcription factor HSF1 and increased levels of inducible heat shock proteins

Genes to Cells

Volumn 16, Issue 12, 2011, Pages 1168-1175

  Janus, Patryk ^a   Pakuła Cis, Małgorzata ^a,d   Kalinowska Herok, Magdalena ^a   Kashchak, Natalia ^a,e   Szołtysek, Katarzyna ^a   Pigłowski, Wojciech ^a   Widlak, Wieslawa ^a   Kimmel, Marek ^b,c   Widlak, Piotr ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b Rice University   (United States)

^c SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

^d AARHUS UNIVERSITY   (Denmark)

^e INSTITUTE OF CELL BIOLOGY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRESS;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL NUCLEUS; CYTOSOL; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HOT TEMPERATURE; HUMANS; NF-KAPPA B; OSTEOSARCOMA; PLASMIDS; POLYMERASE CHAIN REACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 82355191506     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2011.01560.x     Document Type: Article

References (32)

1. Chen, Y. & Currie, R.W. (2006) Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NFκB and AP-1 in vascular smooth muscle cells. Cardiovasc. Res. 69, 66-75.
2. Ciocca, D.R. & Calderwood, S.K. (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10, 86-103.
3. Courtois, G. & Gilmore, T.G. (2006) Mutations in the NF-κB signaling pathway: implications for human disease. Oncogene 25, 6831-6843.
4. Curry, H.A., Clemens, R.A., Shah, S., Bradbury, C.M., Bolero, A., Goswami, P. & Gius, D. (1999) Heat shock inhibits radiation-induced activation of NF-κB via inhibition of I-κB kinase. J. Biol. Chem. 274, 23061-23067.
5. Dai, C., Whitesell, L., Rogers, A.B. & Lindquist, S. (2007) Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130, 1005-1018.
6. Daugaard, M., Rohde, M. & Jäättelä, M. (2007) The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett. 581, 3702-3710.
7. Feinstein, D.L., Galea, E., Aquino, D.A., Li, G.C., Xu, H. & Reis, D.J. (1996) Heat shock protein 70 suppresses astroglial-inducible nitric oxide synthase expression by decreasing NF-κB activation. J. Biol. Chem. 271, 17224-17232.
8. Feinstein, D.L., Galea, E. & Reis, D.J. (1997) Suppression of glial nitric oxide synthase induction by heat shock: effects on proteolytic degradation of IκB-α. Nitric Oxide 1, 167-176.
9. Goldring, C.E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D.A., Sester, D., Mignotte, B. & Jeannin, J.F. (2000) Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene. FASEB J. 14, 2393-2395.
10. Hayden, M.S. & Ghosh, S. (2004) Signaling to NF-κB. Genes Dev. 18, 2195-2224.
11. Inouye, S., Fujimoto, M., Nakamura, T., Takaki, E., Hayashida, N., Hai, T. & Nakai, A. (2007) Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor. J. Biol. Chem. 282, 33210-33217.
12. Jäättelä, M. & Wiking, D. (1993) Heat shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self protection. J. Exp. Med. 177, 231-236.
13. Knowlton, A.A. (2006) NFκB, heat shock proteins, HSF-1, and inflammation. Cardiovasc. Res. 69, 7-8.
14. Lee, K.H., Hwang, Y.H., Lee, C.T., Kim, Y.W., Han, S.K., Shim, Y.S. & Yoo, C.G. (2004) The heat-shock-induced suppression of the IκB/NF-κB cascade is due to inactivation of upstream regulators of IκBα through insolubilization. Exp. Cell Res. 299, 49-56.
15. Lee, K.H., Lee, C.T., Kim, Y.W., Han, S.K., Shim, Y.S. & Yoo, C.G. (2005) Heat shock protein 70 negatively regulates the heat-shock-induced suppression of the IκB/NF-κB cascade by facilitating IκB kinase renaturation and blocking its further denaturation. Exp. Cell Res. 307, 276-284.
16. Malhotra, V., Eaves-Pyles, T., Odoms, K., Quaid, G., Shanley, T.P. & Wong, H.R. (2002) Heat shock inhibits activation of NF-kappaB in the absence of heat shock factor-1. Biochem. Biophys. Res. Commun. 291, 453-457.
17. Nakai, A., Suzuki, M. & Tanabe, M. (2000) Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J. 19, 1545-1554.
18. Park, K.-J., Gaynor, R.B. & Kwak, Y.T. (2003) Heat Shock Protein 27 association with the IκB-Kinase complex regulates Tumor Necrosis Factor α-induced NF-κB activation. J. Biol. Chem. 278, 35272-35278.
19. Perkins, N.D. (2004) NF-κB: tumor promotor or suppressor. Trends Cell Biol. 14, 64-69.
20. Perkins, N.D. (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 8, 49-62.
21. Pirkkala, L., Nykanen, P. & Sistonen, L. (2001) Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 15, 1118-1131.
22. Ran, R., Lu, A., Zhang, L., Tang, Y., Zhu, H., Xu, H., Feng, Y., Han, C., Zhou, G., Rigby, A.C. & Sharp, F.R. (2004) Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev. 18, 1466-1481.
23. Singh, I.S., He, J.R., Calderwood, S. & Hasday, J.D. (2002) A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor. J. Biol. Chem. 277, 4981-4988.
24. Takii, R., Inouye, S., Fujimoto, M., Nakamura, T., Shinkawa, T., Prakasam, R., Tan, K., Hayashida, N., Ichikawa, H., Hai, T. & Nakai, A. (2010) Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3. J. Immunol. 184, 1041-1048.
25. Voellmy, R. (2004) On mechanisms that control heat shock transcription factor activity in metazoan cells. Cell Stress Chaperones 9, 122-133.
26. Vydra, N., Malusecka, E., Jarzab, M., Lisowska, K., Głowala-Kosinska, M., Benedykt, K., Widlak, P., Krawczyk, Z. & Widlak, W. (2006) Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells. Cell Death Differ. 13, 212-222.
27. Widlak, W., Vydra, N., Malusecka, E., Dudaladava, V., Winiarski, B., Ścieglinska, D. & Widlak, P. (2007) Heat shock transcription factor 1 down-regulates spermatocyte-specific 70kDa heat shock protein expression prior to the induction of apoptosis in mouse testes. Genes Cells 12, 487-499.
28. Wong, H.R., Ryan, M. & Wispé, J.R. (1997a) Stress response decreases NFκB nuclear translocation and increases IκBα expression in A549 cells. J. Clin. Invest. 99, 2423-2428.
29. Wong, H.R., Ryan, M. & Wispé, J.R. (1997b) The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking Iκ-B degradation and NF-κB nuclear translocation. Biochem. Biophys. Res. Commun. 231, 257-263.
30. Xiao, X., Zuo, X., Davis, A.A., McMillan, D.R., Curry, B.B., Richardson, J.A. & Benjamin, I.J. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 18, 5943-5952.
31. Yamamoto, A., Mizukami, Y. & Sakurai, H. (2005) Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae. J. Biol. Chem. 280, 11911-11919.
32. Yamamoto, Y. & Gaynor, R.B. (2004) IκB kinases: key regulators of the NF-κB pathway. Trends Biochem. Sci. 29, 72-79.