Identification of a TPX2-like microtubule-associated protein in Drosophila

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Goshima, Gohta ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; INSECT PROTEIN; KINESIN 5; MEI 38 PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN SSP1; TPX2 LIKE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTROMERE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DROSOPHILA; ENZYME BINDING; GENE SILENCING; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; METAPHASE; MICROTUBULE ASSEMBLY; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CHROMOSOME SEGREGATION; CONSERVED SEQUENCE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; KINETOCHORES; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 82355183877     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028120     Document Type: Article

References (40)

1. Walczak CE, Heald R, (2008) Mechanisms of mitotic spindle assembly and function. Int Rev Cytol 265: 111-158.
2. Goshima G, Scholey JM, (2010) Control of mitotic spindle length. Annu Rev Cell Dev Biol 26: 21-57.
3. Heald R, Tournebize R, Blank T, Sandaltzopoulos R, Becker P, et al. (1996) Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 382: 420-425.
4. Goshima G, Kimura A, (2010) New look inside the spindle: microtubule-dependent microtubule generation within the spindle. Curr Opin Cell Biol 22: 44-49.
5. Goshima G, Mayer M, Zhang N, Stuurman N, Vale RD, (2008) Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol 181: 421-429.
6. Koffa MD, Casanova CM, Santarella R, Kocher T, Wilm M, et al. (2006) HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol 16: 743-754.
7. Sillje HH, Nagel S, Korner R, Nigg EA, (2006) HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol 16: 731-742.
8. Ems-McClung SC, Zheng Y, Walczak CE, (2004) Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal. Mol Biol Cell 15: 46-57.
9. Kalab P, Heald R, (2008) The RanGTP gradient- a GPS for the mitotic spindle. J Cell Sci 121: 1577-1586.
10. Wittmann T, Boleti H, Antony C, Karsenti E, Vernos I, (1998) Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J Cell Biol 143: 673-685.
11. Garrett S, Auer K, Compton DA, Kapoor TM, (2002) hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Curr Biol 12: 2055-2059.
12. Ozlu N, Srayko M, Kinoshita K, Habermann B, O'Toole ET, et al. (2005) An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. Dev Cell 9: 237-248.
13. Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, et al. (2002) Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nat Cell Biol 4: 871-879.
14. Bird AW, Hyman AA, (2008) Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol 182: 289-300.
15. Wittmann T, Wilm M, Karsenti E, Vernos I, (2000) TPX2, A novel xenopus MAP involved in spindle pole organization. J Cell Biol 149: 1405-1418.
16. Vos JW, Pieuchot L, Evrard JL, Janski N, Bergdoll M, et al. (2008) The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown. Plant Cell 20: 2783-2797.
17. Brunet S, Dumont J, Lee KW, Kinoshita K, Hikal P, et al. (2008) Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. PLoS One 3: e3338.
18. Eckerdt F, Eyers PA, Lewellyn AL, Prigent C, Maller JL, (2008) Spindle pole regulation by a discrete Eg5-interacting domain in TPX2. Curr Biol 18: 519-525.
19. Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, et al. (2001) Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell 104: 83-93.
20. Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, et al. (2004) Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts. Mol Biol Cell 15: 5318-5328.
21. Bayliss R, Sardon T, Vernos I, Conti E, (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell 12: 851-862.
22. Tsai MY, Zheng Y, (2005) Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly. Curr Biol 15: 2156-2163.
23. Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ, (2009) Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Mol Biol Cell 20: 2766-2773.
24. Tulu US, Fagerstrom C, Ferenz NP, Wadsworth P, (2006) Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr Biol 16: 536-541.
25. Zhang G, Breuer M, Forster A, Egger-Adam D, Wodarz A, (2009) Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions. J Cell Sci 122: 535-545.
26. Goshima G, Vale RD, (2005) Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell 16: 3896-3907.
27. Goshima G, Wollman R, Goodwin N, Zhang JM, Scholey JM, et al. (2007) Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316: 417-421.
28. Baker BS, Carpenter AT, (1972) Genetic analysis of sex chromosomal meiotic mutants in Drosophilia melanogaster. Genetics 71: 255-286.
29. Wu C, Singaram V, McKim KS, (2008) mei-38 is required for chromosome segregation during meiosis in Drosophila females. Genetics 180: 61-72.
30. Chintapalli VR, Wang J, Dow JA, (2007) Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet 39: 715-720.
31. Schatz CA, Santarella R, Hoenger A, Karsenti E, Mattaj IW, et al. (2003) Importin alpha-regulated nucleation of microtubules by TPX2. EMBO J 22: 2060-2070.
32. Ma N, Titus J, Gable A, Ross JL, Wadsworth P, (2011) TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle. J Cell Biol 195: 87-98.
33. Manning AL, Compton DA, (2007) Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells. Curr Biol 17: 260-265.
34. Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, et al. (2009) The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A 106: 6998-7003.
35. Goshima G, Vale RD, (2003) The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J Cell Biol 162: 1003-1016.
36. Goshima G, (2010) Assessment of mitotic spindle phenotypes in Drosophila S2 cells. Methods Cell Biol 97: 259-275.
37. Bettencourt-Dias M, Goshima G, (2009) RNAi in Drosophila S2 cells as a tool for studying cell cycle progression. Methods Mol Biol 545: 39-62.
38. Goshima G, Kiyomitsu T, Yoda K, Yanagida M, (2003) Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J Cell Biol 160: 25-39.
39. Li W, Miki T, Watanabe T, Kakeno M, Sugiyama I, et al. (2011) EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. J Cell Biol 193: 973-983.
40. Bieling P, Telley IA, Hentrich C, Piehler J, Surrey T, (2010) Fluorescence microscopy assays on chemically functionalized surfaces for quantitative imaging of microtubule, motor, and +TIP dynamics. Methods Cell Biol 95: 555-580.