Correlation of the antimicrobial activity of ME1036 with its binding affinities to the penicillin-binding proteins from Streptococcus pneumoniae strains

Journal of Antibiotics

Volumn 64, Issue 11, 2011, Pages 741-746

  Hirai, Yoko ^a   Takahata, Sho ^a   Yamada, Keiko ^a   Ida, Takashi ^a   Maebashi, Kazunori ^a  

^a MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

Carbapenem; ME1036; Penicillin binding proteins; Penicillin resistant Streptococcus pneumoniae

Indexed keywords

BETA LACTAM; CARBAPENEM DERIVATIVE; ME 1036; PENICILLIN BINDING PROTEIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BINDING AFFINITY; DRUG POTENCY; FLUOROGRAPHY; GENE MUTATION; GENOTYPE; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; CARBAPENEMS; COLONY COUNT, MICROBIAL; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL VIABILITY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENICILLIN-BINDING PROTEINS; PROTEIN BINDING; STREPTOCOCCUS PNEUMONIAE;

EID: 82355172989     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2011.76     Document Type: Article

References (16)

1. Goto, H., Shimada, K., Ikemoto, H., Oguri, T. & Study Group on Antimicrobial Susceptibility of Pathogens Isolated from Respiratory Infections. Antimicrobial susceptibility of pathogens isolated from more than 10000 patients with infectious respiratory diseases: A 25-year longitudinal study. J. Infect. Chemother. 15, 347-360 (2009).
2. Doern, G. V. et al. Antimicrobial resistance among Streptococcus pneumoniae in the United States: Have we begun to turn the corner on resistance to certain antimicrobial classes? Clin. Infect. Dis. 41, 139-148 (2005). (Pubitemid 40962493)
3. Kurazono, M. et al. In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci. Antimicrob. Agents Chemother. 48, 2831-2837 (2004). (Pubitemid 38989143)
4. Kosowska-Shick, K., McGhee, P. L. & Appelbaum, P. C. Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 54, 1670-1677 (2010).
5. Yamada, M. et al. Crystal structures of biapenem and tebipenem complexed with penicillin-binding proteins 2X and 1A from Streptococcus pneumoniae. Antimicrob. Agents Chemother. 52, 2053-2060 (2008). (Pubitemid 351758542)
6. Contreras-Martel, C., Dahout-Gonzalez, C., Martins Ados, S., Kotnik, M. & Dessen, A. PBP active site flexibility as the key mechanism for beta-lactam resistance in pneumococci. J. Mol. Biol. 387, 899-909 (2009).
7. Cafini,F.et al. Alterations of the penicillin-binding proteins and murM alleles of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin in Spain. J. Antimicrob. Chemother. 57, 224-229 (2006). (Pubitemid 43160162)
8. Dalhoff, A., Nasu, T. & Okamoto, K. Target affinities of faropenem to and its impact on the morphology of gram-positive and gram-negative bacteria. Chemotherapy 49, 172-183 (2003). (Pubitemid 36928692)
9. Ho, P. L., Chiu, S. S., Ang, I. & Lau, Y. L. Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009. Vaccine 29, 3270-3275 (2011).
10. Rozenbaum, M. H., Boersma, C., Postma, M. J. & Hak, E. Observed differences in invasive pneumococcal disease epidemiology after routine infant vaccination. Expert Rev. Vaccines 10, 187-199 (2011).
11. Yao, K. H. et al. Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia. Vaccine 29, 2296-2301 (2011).
12. Kobayashi, R. et al. In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae. Antimicrob. Agents Chemother. 49, 889-894 (2005). (Pubitemid 40327701)
13. Ubukata, K. et al. Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002. Antimicrob. Agents Chemother. 48, 1488-1494 (2004). (Pubitemid 38544349)
14. Clinical and Laboratory Standards Institute.. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved standard M7-A7 (Clinical and Laboratory Standards Institute: Wayne, PA, 2006).
15. Garcia, P., Garcia, J. L., Garcia, E. & Lopez, R. Nucleotide sequence and expression of the pneumococcal autolysin gene from its own promotor in Escherichia coli. Gene 43, 265-272 (1986). (Pubitemid 16015378)
16. Utsui, Y. & Yokota, T. Role of an altered penicillin-binding protein in methicillinand cephem-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 28, 397-403 (1985). (Pubitemid 15016630)