Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41852-41861

  Mao, Yifan ^a,b   Shang, Yonglei ^a   Pham, Victoria C ^a   Ernst, James A ^a   Lill, Jennie R ^a   Scales, Suzie J ^a   Zha, Jiping ^a,c  

^a GENENTECH INC   (United States)

^b Mendel Biotechnology   (United States)

^c Crown Bioscience Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; ANTIPROLIFERATIVE ACTIVITIES; BREAST CANCER CELLS; CELLULAR RESPONSE; DOWN-REGULATION; INSULIN-LIKE GROWTH FACTOR-I; LIGAND STIMULATION; LYSINE RESIDUES; MOLECULAR CASCADES; POLYUBIQUITIN; POLYUBIQUITINATION; RELATIVE STABILITIES; RESISTANCE MECHANISMS; UBIQUITINATION;

AMINO ACIDS; ANTIBODIES; CELL CULTURE; DISEASES; PEPTIDES; PHOSPHORYLATION;

INSULIN;

H10H5 ANTIBODY; LYSINE; RECEPTOR ANTIBODY; SOMATOMEDIN C RECEPTOR; UBIQUITIN; UNCLASSIFIED DRUG;

ACTIVATION LOOP; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; INTERNALIZATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; UBIQUITINATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; IMMUNOLOGIC CAPPING; INSULIN-LIKE GROWTH FACTOR I; MICE; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, IGF TYPE 1; UBIQUITINATION;

EID: 82355171859     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.288514     Document Type: Article

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