SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians

Molecular Genetics and Metabolism

Volumn 104, Issue 4, 2011, Pages 661-665

  Dong, Yan ^a   Guo, Tingwei ^b   Traurig, Michael ^b   Mason, Clint C ^b   Kobes, Sayuko ^b   Perez, Jessica ^b   Knowler, William C ^b   Bogardus, Clifton ^b   Hanson, Robert L ^b   Baier, Leslie J ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Genetic associations; Insulin secretion; SIRT1; Type 2 diabetes

Indexed keywords

DNA; GLUCOSE; INSULIN; SIRTUIN 1;

ADIPOSE TISSUE; ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA SEQUENCE; FAMILY; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; GLUCOSE TOLERANCE TEST; HUMAN; INDIA; INSULIN RELEASE; INSULIN RESPONSE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; POPULATION RESEARCH; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ARIZONA; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INDIANS, NORTH AMERICAN; INSULIN; LINKAGE DISEQUILIBRIUM; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEQUENCE ANALYSIS, DNA; SEX CHARACTERISTICS; SEX FACTORS; SIRTUIN 1; YOUNG ADULT;

PIMA;

EID: 82255191744     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2011.08.001     Document Type: Article

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