Number needed to treat is incorrect without proper time-related considerations

Journal of Clinical Epidemiology

Volumn 65, Issue 1, 2012, Pages 42-46

  Suissa, Daniel ^a   Brassard, Paul ^b,c   Smiechowski, Brielan ^b,c   Suissa, Samy ^b,c  

^a NOTRE DAME HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Biostatistics; Epidemiology; Impact measure; Methods; Observational studies; Randomized controlled trials

Indexed keywords

ARTICLE; CLINICAL ASSESSMENT TOOL; FOLLOW UP; HUMAN; INCIDENCE; NUMBER NEEDED TO TREAT; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCIENTIFIC LITERATURE; TIME; TREATMENT OUTCOME;

ACYCLOVIR; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BREAST NEOPLASMS; DATA INTERPRETATION, STATISTICAL; DIPHOSPHONATES; EVIDENCE-BASED MEDICINE; FEMALE; FOLLOW-UP STUDIES; HERPES SIMPLEX; HUMANS; IMIDAZOLES; KAPLAN-MEIER ESTIMATE; LIFE TABLES; PERIODICALS AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; RISK ASSESSMENT; RISK FACTORS; SAMPLE SIZE; SURVIVAL RATE; TIME FACTORS; VALINE;

EID: 82255175055     PISSN: 08954356     EISSN: 18785921     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2011.04.009     Document Type: Article

References (27)

1. A. Laupacis, D.L. Sackett, and R.S. Roberts An assessment of clinically useful measures of the consequences of treatment N Engl J Med 318 1988 1728 1733
2. F.A. McAlister The "number needed to treat" turns 20 - and continues to be used and misused CMAJ 179 2008 549 553
3. S.D. Aaron, and D.A. Fergusson Exaggeration of treatment benefits using the "event-based" number needed to treat CMAJ 179 7 2008 669 671
4. S. Suissa Calculation of number needed to treat N Engl J Med 361 2009 424 425
5. D. Collett Modelling survival data in medical research 1994 Chapman & Hall London, UK
6. D.G. Altman, and P.K. Andersen Calculating the number needed to treat for trials where the outcome is time to an event Br Med J 319 1999 1492 1495
7. S. Wiebe, W.T. Blume, J.P. Girvin, and M. Eliasziw A randomized, controlled trial of surgery for temporal-lobe epilepsy N Engl J Med 345 2001 311 318 (Pubitemid 32703233)
8. M. Kalliomaki, S. Salminen, H. Arvilommi, P. Kero, P. Koskinen, and E. Isolauri Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial Lancet 357 2001 1076 1079 (Pubitemid 32322538)
9. P.J. Meunier, C. Roux, E. Seeman, S. Ortolani, J.E. Badurski, and T.D. Spector The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis N Engl J Med 350 2004 459 468 (Pubitemid 38133766)
10. P.W. Serruys, M.C. Morice, A.P. Kappetein, A. Colombo, D.R. Holmes, and M.J. Mack Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease N Engl J Med 360 2009 961 972
11. R.J. Glynn, E. Danielson, F.A. Fonseca, J. Genest, A.M. Gotto Jr., and J.J. Kastelein A randomized trial of rosuvastatin in the prevention of venous thromboembolism N Engl J Med 360 2009 1851 1861
12. B. Zinman, S.B. Harris, J. Neuman, H.C. Gerstein, R.R. Retnakaran, and J. Raboud Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study Lancet 376 2010 103 111
13. G. Bucaneve, A. Micozzi, F. Menichetti, P. Martino, M.S. Dionisi, and G. Martinelli Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia N Engl J Med 353 2005 977 987 (Pubitemid 41262332)
14. N. Hill, G. Moor, M.M. Cameron, A. Butlin, S. Preston, and M.S. Williamson Single blind, randomised, comparative study of the Bug Buster kit and over the counter pediculicide treatments against head lice in the United Kingdom Br Med J 331 2005 384 387
15. L. Corey, A. Wald, R. Patel, S.L. Sacks, S.K. Tyring, and T. Warren Once-daily valacyclovir to reduce the risk of transmission of genital herpes N Engl J Med 350 2004 11 20 (Pubitemid 38032179)
16. J.V. Tu, J. Bowen, M. Chiu, D.T. Ko, P.C. Austin, and Y. He Effectiveness and safety of drug-eluting stents in Ontario N Engl J Med 357 2007 1393 1402 (Pubitemid 47541971)
17. G. Comi, V. Martinelli, M. Rodegher, L. Moiola, O. Bajenaru, and A. Carra Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial Lancet 374 2009 1503 1511
18. M. Gnant, B. Mlineritsch, W. Schippinger, G. Luschin-Ebengreuth, S. Postlberger, and C. Menzel Endocrine therapy plus zoledronic acid in premenopausal breast cancer N Engl J Med 360 2009 679 691
19. P. Kannus, J. Parkkari, S. Niemi, M. Pasanen, M. Palvanen, and M. Jarvinen Prevention of hip fracture in elderly people with use of a hip protector N Engl J Med 343 2000 1506 1513
20. M. Hurlen, M. Abdelnoor, P. Smith, J. Erikssen, and H. Arnesen Warfarin, aspirin, or both after myocardial infarction N Engl J Med 347 2002 969 974
21. S. Hulley, C. Furberg, E. Barrett-Connor, J. Cauley, D. Grady, and W. Haskell Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II) JAMA 288 2002 58 66 (Pubitemid 34705519)
22. D.J. Graham, J.A. Staffa, D. Shatin, S.E. Andrade, S.D. Schech, and G.L. La Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs JAMA 292 2004 2585 2590 (Pubitemid 39577514)
23. H.M. Colhoun, D.J. Betteridge, P.N. Durrington, G.A. Hitman, H.A. Neil, and S.J. Livingstone Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial Lancet 364 2004 685 696 (Pubitemid 39140624)
24. N.S. Beckett, R. Peters, A.E. Fletcher, J.A. Staessen, L. Liu, and D. Dumitrascu Treatment of hypertension in patients 80 years of age or older N Engl J Med 358 2008 1887 1898 (Pubitemid 351620109)
25. J.P. Forman, M.J. Stampfer, and G.C. Curhan Diet and lifestyle risk factors associated with incident hypertension in women JAMA 302 2009 401 411
26. P.M. Calverley, J.A. Anderson, B. Celli, G.T. Ferguson, C. Jenkins, and P.W. Jones Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease N Engl J Med 356 2007 775 789 (Pubitemid 46294610)
27. J. Lacroix, P.C. Hebert, J.S. Hutchison, H.A. Hume, M. Tucci, and T. Ducruet Transfusion strategies for patients in pediatric intensive care units N Engl J Med 356 2007 1609 1619 (Pubitemid 46631670)