Depressive symptoms in patients with hepatitis C treated with pegylated interferon alpha therapy: A 24-week prospective study

Psychiatria Danubina

Volumn 23, Issue 4, 2011, Pages 370-377

  Pavlović, Zorana ^a   Délić, Dragan ^a,b   Marić, Nadja P ^a,b   Vuković, Olivera ^a,b   Jašović Gašić, Miroslava ^a,b  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Assessment; Depressive symptoms; Hepatitis C; Interferon alpha

Indexed keywords

PEGINTERFERON ALPHA; RIBAVIRIN;

ADULT; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HAMILTON SCALE; HEPATITIS C; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; RATING SCALE; RISK FACTOR; SELF EVALUATION; ZUNG SELF RATING DEPRESSION SCALE;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; COMORBIDITY; DEPRESSIVE DISORDER; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; PERSONALITY INVENTORY; PSYCHOMETRICS; RIBAVIRIN; RISK FACTORS; YOUNG ADULT;

EID: 82155191314     PISSN: 03535053     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Altindag A, Ozbulut O, Ozen S, Ucmak H. Interferon-alpha-induced mood disorder with manic features. Gen Hosp Psychiatry 2001; 23:168-70. (Pubitemid 32586823)
2. Beratis S, Katrivanou A, Georgiou S, Monastirli A, Pasmatzi E, Gourzis P, Tsambaos D. Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-alpha treatment J Psychosom Res 2005; 58:15-8. (Pubitemid 40354337)
3. Bonaccorso S, Puzella A, Marino V, Pasquini M, Biondi M, Artini M et al. Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms Psychiatry Res 2001; 105:45-55. (Pubitemid 34015882)
4. Bonaccorso S, Marino V, Biondi M, Grimaldi F, Ippoliti F, Maes M. Depression induced by treatment with interferon-alpha in patient affected by hepatitis C virus. J Affect Disord 2002; 72:237-41. (Pubitemid 35351283)
5. Cai W, Khaoustov VI, Xie Q, Pan T, Le W, Yoffe B. Interferon-alpha- induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. J Hepatol 2005; 42:880-7.
6. Crone C, Gabriel GM. Comprehensive review of hepatitis C for psychiatrists: risks, screening, diagnosis, treatment, and interferon-based therapy complications. J Psychiatr Pract 2003; 9:93-110. (Pubitemid 36717609)
7. Davidson JR, Meltzer-Brody SE. The underrecognition and undertreatment of depression: what is the breadth and depth of the problem? J Clin Psychiatry 1999; 60:4-9.
8. Davis GL, Esteban-Mur R, Rustgi V, Hoefs J, Gordon SC, Trepo C et al. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N Engl J Med 1998;339:1493-9. (Pubitemid 28543497)
9. Davis GL. Treatment of chronic hepatitis C. BMJ 2001; 323:1141-2. (Pubitemid 33078158)
10. Delić D. Infectious diseases.Beograd: Institute for text books and teaching materials, 2001.
11. Delić D. Efficacy and safety of peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C virus infection. Medicinski Pregled 2006; 59:415-9.
12. Dieperink E, Willenbring M, Ho SB. Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: A review. Am J Psychiatry 2000; 157:867-76. (Pubitemid 30412335)
13. Edlin BR, Seal KH, Lorvick J, Kral AH, Ciccarone DH, Moore LD et al. Is it justifiable to withhold treatment for hepatitis C from illicit-drug users? N Engl J Med 2001; 345:211-4. (Pubitemid 32662133)
14. Gharry MG, Strader DB, Thomas DL, Seeff LB, American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009; 49:1335-74.
15. Golden J, Dwyer AM, Conroy R. Depression and anxiety in patients with hepatitis C:prevalence, detection rates and risk factors. Gen Hosp Psychiatry 2005; 27:431-8. (Pubitemid 41566070)
16. Goodman ZD, Ishak KG. Histopathology of hepatitis C virus infection. Semin Liver Dis 1995; 15:70-81.
17. Grothe B, Dutton R, Jones N, Bodenlos J, Ancona M, Brantley J. Validation of the Beck Depression Inventory-II in a low-income African American sample of medical outpatients. Psychol Assess 2005; 17:110-4. (Pubitemid 40389391)
18. Fontana RJ, Kronfol Z, Lindsay KL, Bieliauskas LA, Padmanabhan L, Back-Madruga C et al. Changes in mood states and biomarkers during peginterferon and ribavirin treatment of chronic hepatitis C. Am J Gastroenterol 2008; 103:2766-75.
19. Hamilton M: A rating scale for depression. J Neural Psychiatry 1960; 23:56-62.
20. Harris M. Injecting, Infection, Illness: Abjection and Hepatitis C Stigma. Body & Society 2009; 15:33-51.
21. Hauser P, Khosla J, Aurora H, Laurin J, Kling MA, Hill J et al. A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. Mol psychiatry 2002; 7:942-7. (Pubitemid 35333048)
22. Horikawa N, Yamazaki T, Izumi N, Uchihara M. Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: a prospective study. General Hospital Psychiatry 2003; 25:34-8. (Pubitemid 36173783)
23. Hosoda S, Takimura H, Shibayama M, Kanamura H, Ikeda K, Kumada H. Psychiatric symptoms related to interferon therapy for chronic hepatitis C: clinical features i prognosis. Psychiatry Clin Neurosci 2000; 54:565-72.
24. Kraus MR, Schäfer A, Faller H, Csef H, Scheurlen M.Psychiatric symptoms in patients with chronic hepatitis C receiving interferon alfa-2b therapy. J Clin Psychiatry 2004; 65:581-2.
25. Lee DH, Jamal H, Regenstein FG, Perrillo RP. Morbidity of chronic hepatitis C as seen in a tertiary care medical center. Dig Dis Sci 1997; 42:186-91. (Pubitemid 27059942)
26. Lotrich F, Rabinovitz M, Gironda P, Pollock B. Depression following pegylated interferon-alpha: characteristics and vulnerability. J Psychosom Res 2007; 63:131-5. (Pubitemid 47088561)
27. Majeed S, Memon A, Abdi MA. Frequency of Depression Among Hepatitis C Patients. KUST Med J 2009;1(2):42-5.
28. Mamman A, Yusuf AJ, Aminu Sm, Sheikh TL, Hassan A. Severe depression following á-interferon usage in a patient with chronic myeloid leukemia. Afr Health Sci 2009; 9:54-6.
29. Martín-Santos R, Díez-Quevedo C, Castellví P, Navinés R, Miquel M, Masnou H et al. De novo depression and anxiety disorders and influence onadherence during peginterferon-alpha-2a and ribavirin treatment in patients with hepatitis. Aliment Pharmacol Ther 2008; 27:257-65.
30. Matthews SC, Paulus MP, Dimsdale JE. Contribution of functional neuroimaging to understanding neuropsychiatric side effects of interferon in hepatitis C. Psychosomatics 2004; 45:281-6. (Pubitemid 38823601)
31. Mulder RT, Ang M, Chapman B, Ross A, Stevens IF, Edgar C et al. Edgar. Interferon treatment is not associated with a worsening of psychiatric symptoms in patients with hepatitis. J Gastroenterol Hepatol 2000; 15:300-3. (Pubitemid 30190745)
32. Navinés R, Gómez-Gil E, Puig S, Baeza I, De Pablo J, Martin-Santos R. Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: primary to induced disorders. Eur J Dermatol 2009; 19:611-5.
33. Nešić Z, Delić D, Prostran M, Sojanović R, Vuèković S, Todorović Z. Psychiatric side effects of the application of recombined interferon alpha in chronic hepatitis C patients. Medicinski Pregled 2004; 57:219-26.
34. Obhrai J, Hall Y, Anand BS. Assessment of fatigue and psychologic disturbances in patients with hepatitis C virus infection. J Clin Gastroenterol 2001; 32:413-7. (Pubitemid 32378274)
35. Orru M, Pariante CM. Depression and liver diseases. Dig Liver Dis 2005;37:564-5. (Pubitemid 44382337)
36. Pariante CM, Landau S, Carpiniello B. Interferon alfa-induced adverse effects in patients with a psychiatric diagnosis. N Engl J Med 2002; 347:148-9. (Pubitemid 34753496)
37. Raison CL, Borisov AS, Broadwell SD, Capuron L, Woolwine BJ, Jacobson IM et al. Depression during pegylated interferon-alpha plus ribavirin therapy: Prevalence and prediction. J Clin Psychiatry 2005; 66:41-8.
38. Reichenberg A, Gorman JM, Dieterich DT. Interferon-induced depression and cognitive impairment in hepatitis C virus patients: a 72 week prospective study. AIDS 2005; 19 (Suppl 3):174-8.
39. Sakamoto H, Inoue K, Shimada M, Yoshida H, Otsubo T, Miyaoka H et al. Depressionduring interferon therapy in renal cell cancer patients - comparison with chronic hepatitis C patients. Nippon Hinyokika Gakkai Zasshi 2000; 91:611-7.
40. Schaefer M, Schmidt F, Neumer R, Scholler G, Schwarz M. Interferon-alpha, cytokines and possible implications for mood disorders. Bipolar Disord 2002; 4(Suppl 1): 111-3.
41. Schaefer M, Schwaiger M, Garkisch AS, Pich M, Hinzpeter A, Uebelhack R et al. Prevention of interferon-alpha associated depression in psychiatric risk patients with chronic hepatitis C. J Hepatol 2005; 42:793-8. (Pubitemid 40693194)
42. Schafer A, Wittchen H, Seufert J, Kraus M. Methodological approaches in the assesment of interferon-alfa-induced depression in patients with chronic hepatitis C-a critical review. Int J Methods Psychiatr Res 2007; 16:186-201. (Pubitemid 351150050)
43. Schaefer M, Mauss S. Hepatitis C treatment in patients with drug addiction: clinical management of interferon-alpha-associated psychiatric side effects. Curr Drug Abuse Rev 2008; 1:177-87.
44. Tsao CW, Lin YS, Cheng JT, Lin CF, Wu HT, Wu SR et al. Interferon-alpha-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. J Psychopharmacol 2008; 22:753-60.
45. Weissenborn K, Tryc AB, Heeren M, Worthmann H, Pflugrad H, Berding G et al. Hepatitis C virus infection and the brain. Metab Brain Dis 2009; 24:197-210.
46. Park Y, Lee JH,Kim BS, Kim DY, Han KH, Kim HS. HCV RNA Quantification. Antigen Assay as an Alternative to Real-Time PCR for 2010. New Automated Hepatitis C Virus (HCV). J Clin Microbiol 2010.
47. Uzun S, Kozumplik O, Topic R & Jakovljevic M. Depressive disorders and comorbidity: somatic illness vs. Side effects. Psychiatria Danubina 2009; 21:391-8.
48. Younossi ZM, McHutchison JG. Serological tests for HCV infection. Hepatitis Rev 1996; 2:161-73.
49. Zung WW. Self-rating depression scale in an outpatient clinic. Further validation of the SDS. Arch Gen Psychiatry 1965; 13:508-15.