Non-adherence to drug therapy and drug acquisition costs in a national population - A patient-based register study

BMC Health Services Research

Volumn 11, Issue , 2011, Pages

  Hovstadius, Bo ^a   Petersson, Göran ^a  

^a LINNAEUS UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CHILD; DRUG COST; FEMALE; HUMAN; INFANT; MALE; MIDDLE AGED; PATIENT COMPLIANCE; PRESCHOOL CHILD; REGISTER; STATISTICAL MODEL; STATISTICS; SWEDEN;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DRUG COSTS; FEMALE; HUMANS; INFANT; MALE; MEDICATION ADHERENCE; MIDDLE AGED; MODELS, ECONOMIC; REGISTRIES; SWEDEN; YOUNG ADULT;

EID: 82155186111     PISSN: None     EISSN: 14726963     Source Type: Journal    
DOI: 10.1186/1472-6963-11-326     Document Type: Article

References (65)

1. A meta-analysis of the association between adherence to drug therapy and mortality. Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, Johnson JA, BMJ 2006 333 7557 15 10.1136/bmj.38875.675486.55 16790458
2. Impact of medication adherence on hospitalization risk and healthcare cost. Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS, Med Care 2005 43 6 521 530 10.1097/01.mlr.0000163641.86870.af 15908846 (Pubitemid 40847288)
3. Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. Rasmussen JN, Chong A, Alter DA, JAMA 2007 297 2 177 186 10.1001/jama.297.2.177 17213401 (Pubitemid 46089734)
4. Patient adherence to treatment: three decades of research. A comprehensive review. Vermeire E, Hearnshaw H, Van Royen P, Denekens J, J Clin Pharm Ther 2001 26 5 331 342 10.1046/j.1365-2710.2001.00363.x 11679023 (Pubitemid 32989555)
5. Adherence to long-term therapies: evidence for action. World Health Organization 2003
6. Treatment adherence in chronic disease. Dunbar-Jacob J, Mortimer-Stephens MK, J Clin Epidemiol 2001 54 Suppl 1 57 60 11750211
7. Patients at-risk for cost-related medication nonadherence: a review of the literature. Briesacher BA, Gurwitz JH, Soumerai SB, J Gen Intern Med 2007 22 6 864 871 10.1007/s11606-007-0180-x 17410403 (Pubitemid 46763978)
8. Unfilled prescriptions of medicare beneficiaries: prevalence, reasons, and types of medicines prescribed. Kennedy J, Tuleu I, Mackay K, J Manag Care Pharm 2008 14 6 553 560 18693779
9. Health insurance status, cost-related medication underuse, and outcomes among diabetes patients in three systems of care. Piette JD, Wagner TH, Potter MB, Schillinger D, Med Care 2004 42 2 102 109 10.1097/01.mlr.0000108742.26446.17 14734946
10. Measurement, correlates, and health outcomes of medication adherence among seniors. Vik SA, Maxwell CJ, Hogan DB, Ann Pharmacother 2004 38 2 303 312 14742770 (Pubitemid 38112246)
11. Factors associated with adherence to drug therapy: a population-based study. Bardel A, Wallander MA, Svardsudd K, Eur J Clin Pharmacol 2007 63 3 307 314 10.1007/s00228-006-0246-4 17211620 (Pubitemid 46233159)
12. Unclaimed prescriptions after automated prescription transmittals to pharmacies. Ekedahl A, Mansson N, Pharm World Sci 2004 26 1 26 31 15018256 (Pubitemid 38250177)
13. Adherence to multiple, prescribed medications in diabetic kidney disease: A qualitative study of consumers' and health professionals' perspectives. Williams AF, Manias E, Walker R, Int J Nurs Stud 2008 45 12 1742 1756 10.1016/j.ijnurstu.2008.07.002 18701103
14. Primary medication non-adherence: analysis of 195, 930 electronic prescriptions. Fischer MA, Stedman MR, Lii J, Vogeli C, Shrank WH, Brookhart MA, Weissman JS, J Gen Intern Med 25 4 284 290
15. New prescription medication gaps: a comprehensive measure of adherence to new prescriptions. Karter AJ, Parker MM, Moffet HH, Ahmed AT, Schmittdiel JA, Selby JV, Health Serv Res 2009 44 5 Pt 1 1640 1661 19500161
16. Maximizing patient adherence for optimal outcomes in psoriasis. Bewley A, Page B, J Eur Acad Dermatol Venereol 25 Suppl 4 9 14
17. Cost-related prescription nonadherence in the United States and Canada: a system-level comparison using the 2007 International Health Policy Survey in Seven Countries. Kennedy J, Morgan S, Clin Ther 2009 31 1 213 219 10.1016/j.clinthera.2009.01.006 19243719
18. Folkhälsorapport 2009 [Public Health report 2009] Swedish. Socialstyrelsen, Stockholm, Sweden 2009
19. Cost-related skipping of medications and other treatments among Medicare beneficiaries between 1998 and 2000. Results of a national study. Wilson IB, Rogers WH, Chang H, Safran DG, J Gen Intern Med 2005 20 8 715 720 10.1111/j.1525-1497.2005.0128.x 16050880 (Pubitemid 41149107)
20. Comparison of drug adherence rates among patients with seven different medical conditions. Briesacher BA, Andrade SE, Fouayzi H, Chan KA, Pharmacotherapy 2008 28 4 437 443 10.1592/phco.28.4.437 18363527 (Pubitemid 351466455)
21. Comparing adherence and persistence across 6 chronic medication classes. Yeaw J, Benner JS, Walt JG, Sian S, Smith DB, J Manag Care Pharm 2009 15 9 728 740 19954264
22. Studies of Drug Utilization. Lee RD, Bergman U, Pharmacoepidemiology Chichester: John Wiley & Sons Ltd, Strom BL, Fourth 2005 401 417
23. Adherence to medication. Osterberg L, Blaschke T, N Engl J Med 2005 353 5 487 497 10.1056/NEJMra050100 16079372 (Pubitemid 41127293)
24. Patient compliance with antibiotic treatment for respiratory tract infections. Kardas P, J Antimicrob Chemother 2002 49 6 897 903 10.1093/jac/dkf046 12039881 (Pubitemid 34692883)
25. Primary compliance with medication prescribed for paediatric patients discharged from a regional hospital. Wright H, Forbes D, Graham H, J Paediatr Child Health 2003 39 8 611 612 10.1046/j.1440-1754.2003.00241.x 14629528 (Pubitemid 37463945)
26. Clinical consequences of polypharmacy in elderly: expect the unexpected, think the unthinkable. Salazar JA, Poon I, Nair M, Expert Opin Drug Saf 2007 6 6 695 704 10.1517/14740338.6.6.695 17967158 (Pubitemid 351308281)
27. Escalating polypharmacy. Gorard DA, QJM 2006 99 11 797 800 10.1093/qjmed/hcl109 17030528 (Pubitemid 44688412)
28. Methods for estimating the occurrence of polypharmacy by means of a prescription database. Bjerrum L, Rosholm JU, Hallas J, Kragstrup J, Eur J Clin Pharmacol 1997 53 1 7 11 10.1007/s002280050329 9349923 (Pubitemid 27430023)
29. Polypharmacy: the cure becomes the disease. Colley CA, Lucas LM, J Gen Intern Med 1993 8 5 278 283 10.1007/BF02600099 8505690 (Pubitemid 23169392)
30. Three complementary definitions of polypharmacy: methods, application and comparison of findings in a large prescription database. Fincke BG, Snyder K, Cantillon C, Gaehde S, Standring P, Fiore L, Brophy M, Gagnon DR, Pharmacoepidemiol Drug Saf 2005 14 2 121 128 10.1002/pds.966 15386712 (Pubitemid 40253621)
31. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. Rollason V, Vogt N, Drugs Aging 2003 20 11 817 832 10.2165/00002512-200320110-00003 12964888 (Pubitemid 37159599)
32. Daily regimen and compliance with treatment. Bloom BS, BMJ 2001 323 7314 647 10.1136/bmj.323.7314.647 11566816
33. Predictors of medication adherence in the elderly. Balkrishnan R, Clin Ther 1998 20 4 764 771 10.1016/S0149-2918(98)80139-2 9737835 (Pubitemid 28421497)
34. Drug therapy in the elderly: what doctors believe and patients actually do. Barat I, Andreasen F, Damsgaard EM, Br J Clin Pharmacol 2001 51 6 615 622 10.1046/j.0306-5251.2001.01401.x 11422022 (Pubitemid 32862751)
35. A systematic review of adherence with medications for diabetes. Cramer JA, Diabetes Care 2004 27 5 1218 1224 10.2337/diacare.27.5.1218 15111553 (Pubitemid 38579798)
36. Determinants of self-reported medicine underuse due to cost: a comparison of seven countries. Kemp A, Roughead E, Preen D, Glover J, Semmens J, J Health Serv Res Policy 15 2 106 114
37. Refill non-adherence to repeat prescriptions leads to treatment gaps or to high extra costs. Krigsman K, Melander A, Carlsten A, Ekedahl A, Nilsson JL, Pharm World Sci 2007 29 1 19 24 10.1007/s11096-005-4797-8 17268941 (Pubitemid 46295171)
38. The new Swedish Prescribed Drug Register - opportunities for pharmacoepidemiological research and experience from the first six months. Wettermark B, Hammar N, MichaelFored C, Leimanis A, Otterblad Olausson P, Bergman U, Persson I, Sundstrom A, Westerholm B, Rosen M, Pharmacoepidemiol Drug Saf 2007 16 7 726 735 10.1002/pds.1294 16897791 (Pubitemid 47180362)
39. Dispensed drugs and multiple medications in the Swedish population: an individual-based register study. Hovstadius B, Astrand B, Petersson G, BMC Clin Pharmacol 2009 9 1 11 19473486
40. The Swedish national pharmacy register. Astrand B, Hovstadius B, Antonov K, Petersson G, Stud Health Technol Inform 2007 129 345 349 17911736
41. Do patients cash prescriptions? Rashid A, Br Med J (Clin Res Ed) 1982 284 6308 24 26 10.1136/bmj.284.6308.24
42. Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction. Jackevicius CA, Li P, Tu JV, Circulation 2008 117 8 1028 1036 10.1161/CIRCULATIONAHA.107.706820 18299512
43. Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Hess LM, Raebel MA, Conner DA, Malone DC, Ann Pharmacother 2006 40 7-8 1280 1288 16868217 (Pubitemid 44204957)
44. Electronically transmitted prescriptions not picked up at pharmacies in Sweden. Ax F, Ekedahl A, Res Social Adm Pharm 6 1 70 77
45. Management and treatment perceptions among young adults with asthma in Melbourne: the Australian experience from the European Community Respiratory Health Survey. Reid D, Abramson M, Raven J, Walters HE, Respirology 2000 5 3 281 287 10.1046/j.1440-1843.2000.00265.x 11022992
46. One in 3 prescriptions are never redeemed: primary nonadherence in an outpatient clinic. Storm A, Andersen SE, Benfeldt E, Serup J, J Am Acad Dermatol 2008 59 1 27 33 10.1016/j.jaad.2008.03.045 18467003
47. Methods for evaluation of medication adherence and persistence using automated databases. Andrade SE, Kahler KH, Frech F, Chan KA, Pharmacoepidemiol Drug Saf 2006 15 8 565 574 discussion 575-567 10.1002/pds.1230 16514590 (Pubitemid 44336271)
48. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. DiMatteo MR, Med Care 2004 42 3 200 209 10.1097/01.mlr.0000114908.90348.f9 15076819
49. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM, Int J Clin Pract 2008 62 1 76 87 17983433 (Pubitemid 350294021)
50. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Kothawala P, Badamgarav E, Ryu S, Miller RM, Halbert RJ, Mayo Clin Proc 2007 82 12 1493 1501 10.4065/82.12.1493 18053457 (Pubitemid 350211697)
51. Patient adherence and persistence with oral anticancer treatment. Ruddy K, Mayer E, Partridge A, CA Cancer J Clin 2009 59 1 56 66 10.3322/caac.20004 19147869
52. Factors affecting adherence to antiretroviral therapy. Chesney MA, Clin Infect Dis 2000 30 Suppl 2 171 176 10860902
53. Compliance with medication regimens for mental and physical disorders. Cramer JA, Rosenheck R, Psychiatr Serv 1998 49 2 196 201 9575004 (Pubitemid 28071427)
54. The assessment of refill compliance using pharmacy records: methods, validity, and applications. Steiner JF, Prochazka AV, J Clin Epidemiol 1997 50 1 105 116 10.1016/S0895-4356(96)00268-5 9048695 (Pubitemid 27089212)
55. Importance of including early nonadherence in estimations of medication adherence. Raebel MA, Carroll NM, Ellis JL, Schroeder EB, Bayliss EA, Ann Pharmacother 45 9 1053 1060
56. You wrote the prescription, but will it get filled? Cooke CE, Xing S, Lee HY, Belletti DA, J Fam Pract 60 6 321 327
57. Failure to fill electronically prescribed antidepressant medications: a retrospective study. Xing S, Dipaula BA, Lee HY, Cooke CE, Prim Care Companion CNS Disord 13 1
58. Rational use of medicines: progress in implementing the WHO medicine strategy. Report by the secretariat. Executive Board 118th Session World Health Organization 2006
59. [What are the costs of diseases?] Swedish. Jacobsson L, Lindgren B, Stockholm Sweden: The National Board of Health and Welfare 1996
60. [Statistics-Health and Medical Care] Swedish. Official Statistics of Sweden Stockholm: Socialstyrelsen 2007
61. Impact of postal and telephone reminders on pick-up rates of unclaimed e-prescriptions. Ekedahl A, Oskarsson V, Sundberg B, Gustafsson V, Lundberg T, Gullberg B, Pharm World Sci 2008 30 5 503 508 10.1007/s11096-008-9196-5 18247155
62. Survey on unclaimed prescriptions in a community pharmacy. Hamilton WR, Hopkins UK, J Am Pharm Assoc (Wash) 1997 NS37 3 341 345
63. Postcard and telephone reminders for unclaimed prescriptions: a comparative evaluation using survival analysis. Secnik K, Pathak DS, Cohen JM, J Am Pharm Assoc (Wash) 2000 40 2 243 251 quiz 330-241
64. Can prescription refill feedback to physicians improve patient adherence? Schectman JM, Schorling JB, Nadkarni MM, Voss JD, Am J Med Sci 2004 327 1 19 24 10.1097/00000441-200401000-00005 14722392 (Pubitemid 38095394)
65. Thinking outside the pillbox - medication adherence as a priority for health care reform. Cutler DM, Everett W, N Engl J Med 362 17 1553 1555