An estimate of the dispersion of repolarization times based on a biophysical model of the ECG

IEEE Transactions on Biomedical Engineering

Volumn 58, Issue 12 PART 1, 2011, Pages 3396-3405

  Sassi, Roberto ^a   Mainardi, Luca T ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b POLITECNICO DI MILANO   (Italy)

Author keywords

Cardiac transmembrane potentials (TMPs); dominant T wave (DTW); repolarization heterogeneity; statistical modeling of repolarization times (RTs); T wave analysis

Indexed keywords

DOMINANT T-WAVE (DTW); REPOLARIZATION HETEROGENEITY; STATISTICAL MODELING; T-WAVE ANALYSIS; TRANSMEMBRANE POTENTIALS;

ELECTROPHYSIOLOGY;

ELECTROCARDIOGRAPHY;

ARTICLE; BIOPHYSICS; ELECTROCARDIOGRAM; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; MATHEMATICAL MODEL; REPOLARIZATION; T WAVE; TELEMETRY;

ALGORITHMS; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HUMANS; MALE; MEMBRANE POTENTIALS; MODELS, CARDIOVASCULAR; MODELS, STATISTICAL; MYOCYTES, CARDIAC; REPRODUCIBILITY OF RESULTS; VENTRICULAR FUNCTION;

EID: 82155185306     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2011.2166263     Document Type: Article

References (44)

1. C. S. Kuo, K. Munakata, C. P. Reddy, and B. Surawicz, "Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations," Circulation, vol. 67, no. 6, pp. 1356-1367, 1983. (Pubitemid 13105361)
2. J. A. Vassallo, D. M. Cassidy, K. E. Kindwall, F. E. Marchlinski, and M. E. Josephson, "Nonuniform recovery of excitability in the left ventricle," Circulation, vol. 78, no. 6, pp. 1365-1372, 1988. (Pubitemid 19004237)
3. L. D. Ambroggi, "Heterogeneities of ventricular repolarization and vulnerability to arrhythmia. How to detect them with noninvasive methods?" Cardiologia, vol. 44, no. 4, pp. 355-360, 1999.
4. M. Malik, "Nondipolar electrocardiographic components and myocardial heterogeneity," Ann. Noninvasive Electrocardiol., vol. 14, no. 2, pp. 103-107, 2009.
5. P. D. Arini, G. C. Bertran, E. R. Valverde, and P. Laguna, "T-wave width as an index for quantification of ventricular repolarization dispersion: Evaluation in an isolated rabbit heart model," Biomed. Signal Process. Control, vol. 3, pp. 67-77, 2008. (Pubitemid 351211224)
6. M.Kesek,O.Gustavsson, andU.Wiklund, "Nondipolar content of Twave derived from a myocardial source simulation with increased repolarization inhomogeneity," Ann. Noninvasive Electrocardiol., vol. 14, no. 2, pp. 185-192, 2009.
7. C. P. Day, J. M. McComb, and R. W. Campbell, "QT dispersion: An indication of arrhythmia risk in patients with long QT intervals," Br. Heart J., vol. 63, no. 6, pp. 342-344, 1990. (Pubitemid 20182179)
8. G. X. Yan and C. Antzelevitch, "Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome," Circulation, vol. 98, no. 18, pp. 1928-1936, 1998. (Pubitemid 28509291)
9. A. Minchole, E. Pueyo, J. F. Rodriguez, E. Zacur, M. Doblare, and P. Laguna, "Quantification of restitution dispersion from the dynamic changes of the T-wave peak to end, measured at the surface ECG," IEEE Trans. Biomed. Eng., vol. 58, no. 5, pp. 1172-1182, 2011.
10. C. Antzelevitch, S. Sicouri, J. M. D. Diego, A. Burashnikov, S. Viskin,W. Shimizu, G.-X. Yan, P. Kowey, and L. Zhang, "Does Tpeak -Tend provide an index of transmural dispersion of repolarization?" Heart Rhythm, vol. 4, no. 8, pp. 1114-1116 (Author's reply pp. 1116-1119), 2007. (Pubitemid 47163756)
11. W. Zareba, "Dispersion of repolarization: Time to move beyond QT dispersion," Ann. Noninvasive Electrocardiol., vol. 5, pp. 373-381, 2000. (Pubitemid 32099693)
12. A. J. Moss, "What resides in T-wave residuum?" J. Cardiovasc. Electrophysiol., vol. 16, no. 9, pp. 952-953, 2005.
13. T. Opthof, R. Coronel, F. J. G. Wilms-Schopman, A. N. Plotnikov, I. N. Shlapakova, P. Danilo, M. R. Rosen, and M. J. Janse, "Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion," Heart Rhythm, vol. 4, no. 3, pp. 341-348, 2007. (Pubitemid 46323467)
14. Y. Xia, Y. Liang, O. Kongstad, Q. Liao,M. Holm, B. Olsson, and S. Yuan, "In vivo validation of the coincidence of the peak and end of the T wave with full repolarization of the epicardium and endocardium in swine," Heart Rhythm, vol. 2, no. 2, pp. 162-169, 2005. (Pubitemid 40220820)
15. B. H. V. Huysduynen, C. A. Swenne, H. H. M. Draisma, M. L. Antoni, H. V. D. Vooren, E. E. V. D. Wall, and M. J. Schalij, "Validation of ECG indices of ventricular repolarization heterogeneity:Acomputer simulation study," J. Cardiovasc. Electrophysiol., vol. 16, no. 10, pp. 1097-1103, 2005.
16. D. B. Geselowitz, "Description of cardiac sources in anisotropic cardiac muscle. Application of bidomain model," J. Electrocardiol., vol. 25, no. 1 (suppl.), pp. 65-67, 1992. (Pubitemid 23101751)
17. A. vanOosterom, "Genesis of the Twave as based on an equivalent surface source model," J. Electrocardiol., vol. 34 (suppl.), pp. 217-227, 2001.
18. A. van Oosterom, "The dominant T wave," J. Electrocardiol., vol. 37 (suppl.), pp. 193-197, 2004. (Pubitemid 39452890)
19. W. Miller and D. Geselowitz, "Simulation studies of the electrocardiogram-Part I: The normal heart," Circ. Res., vol. 43, no. 2, pp. 301-315, 1978. (Pubitemid 9004291)
20. L. Tung, "A bi-domain model for describing ischemic myocardial D-C potential" Ph.D. dissertation, Dept. Electr. Eng. Comput. Sci., Massachusetts Inst. Technol., Cambridge, 1978.
21. O. H. Schmitt, "Biological information processing using the concept of interpenetrating domains," in Information Processing in the Nervous System. New York: Springer-Verlag, 1969, pp. 325-331.
22. S. Scacchi, P. C. Franzone, L. Pavarino, and B. Taccardi, "A reliability analysis of cardiac repolarization time markers," Math. Biosci., vol. 219, no. 2, pp. 113-128, 2009.
23. D. B. Geselowitz, "On the theory of the electrocardiogram," Proc. IEEE, vol. 77, no. 6, pp. 857-876, Jun. 1989.
24. R. Plonsey and R. C. Barr, "Current flow patterns in two-dimensional anisotropic bisyncytia with normal and extreme conductivities," Biophys. J., vol. 45, no. 3, pp. 557-571, 1984.
25. A. van Oosterom, "The dominant T wave and its significance," J. Cardiovasc. Electrophysiol., vol. 14, pp. S180-S187, 2003. (Pubitemid 37393001)
26. V. S. Chauhan, E. Downar, K. Nanthakumar, J. D. Parker, H. J. Ross, W. Chan, and P. Picton, "Increased ventricular repolarization heterogeneity in patients with ventricular arrhythmia vulnerability and cardiomyopathy: A human in vivo study," Am. J. Physiol. Heart Circ. Physiol., vol. 290, pp. 79-86, 2006.
27. D. Durrer, R. T. v. Dam, G. E. Freud, M. J. Janse, F. L. Meijler, and R. C. Arzbaecher, "Total excitation of the isolated human heart," Circulation, vol. 41, pp. 899-912, 1970.
28. M. Zaniboni, F. Cacciani, and N. Salvarani, "Temporal variability of repolarization in rat ventricular myocytes paced with time-varying frequencies," Exp. Physiol., vol. 92, no. 5, pp. 859-869, 2007. (Pubitemid 47283905)
29. M. Zaniboni, A. E. Pollard, L. Yang, and K. W. Spitzer, "Beat-to-beat repolarization variability in ventricular myocytes and its suppression by electrical coupling," Am. J. Physiol. Heart Circ. Physiol., vol. 278, no. 3, pp. H677-H687, 2000. (Pubitemid 30152522)
30. J.Walmsley, G.Mirams, M. Bahoshy, C. Bollensdorff, B. Rodriguez, and K. Burrage, "Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes," in Proc. Conf. IEEE Eng. Med. Biol. Soc., 2010, vol. 1, pp. 1457-1460.
31. A. M. Mood, F. A. Graybill, and D. C. Boes, Introduction to the Theory of Statistics, 3rd ed. New York: McGraw-Hill, 1974.
32. A. Papoulis, Probability, Random Variables, and Stochastic Processes, 3rd ed. New York: McGraw-Hill, 1991.
33. L. T. Mainardi and R. Sassi, "Analysis of T wave alternans using the dominant T-wave paradigm," J. Electrocardiol., vol. 44, pp. 119-125, 2011.
34. A. van Oosterom and T. F. Oostendorp, "ECGSIM: An interactive tool for studying the genesis of QRST waveforms," Heart, vol. 90, pp. 165-168, 2004. (Pubitemid 38147151)
35. A. vanOosterom andG. J.Huiskamp, "The effect of torso inhomogeneities on body surface potentials quantified using "tailored" geometry," J. Electrocardiol., vol. 22, pp. 53-72, 1989. (Pubitemid 19056642)
36. P. van Dam, T. Oostendorp, A. Linnenbank, and A. van Oosterom, "Noninvasive imaging of cardiac activation and recovery," Ann. Biomed. Eng., vol. 37, pp. 1739-1756, 2009.
37. J. Smith, E. Clancy, C. Valeri, J. Ruskin, and R. Cohen, "Electrical alternans and cardiac electrical instability," Circulation, vol. 77, no. 1, pp. 110-121, 1988. (Pubitemid 18031007)
38. R. Sassi and L. T. Mainardi, "Refined estimate of the dominant T-wave," Comput. Cardiol., vol. 37, pp. 845-848, 2010.
39. Medical Electrical Equipment-Part 2-51: Particular Requirements for Safety, Including Essential Performance, of Recording and Analysing Single Channel and Multichannel Electrocardiographs, IEC 60601-2-51 Standard, 2003.
40. S. Kaab, M. Hinterseer, M. Nabauer, and G. Steinbeck, "Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome-A case-control pilot study using i.v. sotalol," Eur. Heart J., vol. 24, no. 7, pp. 649-657, 2003. (Pubitemid 36343198)
41. F. Extramiana, R. Dubois, M. Vaglio, P. Roussel, G. Dreyfus, F. Badilini, A. Leenhardt, and P. Maison-Blanche, "The time course of new T-wave ECG descriptors following single-and double-dose administration of sotalol in healthy subjects," Ann. Noninvasive Electrocardiol., vol. 15, no. 1, pp. 26-35, 2010.
42. M. Lemay, J. M. Vesin, A. van Oosterom, V. Jacquemet, and L. Kappenberger, "Cancellation of ventricular activity in the ECG: Evaluation of novel and existing methods," IEEE Trans. Biomed. Eng., vol. 54, no. 3, pp. 542-546, Mar. 2007. (Pubitemid 46371237)
43. A. van Oosterom, "Singular value decomposition of the T wave: Its link with a biophysical model of repolarization," Int. J. Bioelectromagn., vol. 4, pp. 59-60, 2002.
44. G. Barbero and L. R. Evangelista, An Elementary Course on the Continuum Theory for Nematic Liquid Crystals. Singapore: World Scientific, 2000.