MicroRNAs regulating cell pluripotency and vascular differentiation

Vascular Pharmacology

Volumn 55, Issue 4, 2011, Pages 69-78

  Howard, Lynsey ^a   Kane, Nicole M ^a   Milligan, Graeme ^b   Baker, Andrew H ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cardiomyocyte cells; Embryonic stem cells; MicroRNA; Pluripotency; Vascular endothelial cells; Vascular smooth muscle cells

Indexed keywords

MICRORNA; MICRORNA 291A 3P; MICRORNA 291B 3P; MICRORNA 294; MICRORNA 295; MICRORNA 302; UNCLASSIFIED DRUG;

ACCURACY; CARDIOVASCULAR SYSTEM; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL PROLIFERATION; CELL RENEWAL; CELL THERAPY; CELL TYPE; DNA MODIFICATION; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; EPIGENETICS; GENE CONTROL; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; HEART MUSCLE CELL; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; RNA DEGRADATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; VASCULAR DIFFERENTIATION;

ANGIOGENESIS MODULATING AGENTS; ANIMALS; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE;

EID: 82155185185     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2011.08.002     Document Type: Review

References (100)

1. Becker K.A., Stein J.L., Lian J.B., van Wijnen A.J., Stein G.S. Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells. Journal of Cellular Physiology 2007, 210(2):517-526.
2. Benetti R., Gonzalo S., Jaco I., Munoz P., Gonzalez S., Schoeftner S., Murchison E., Andl T., Chen T., Klatt P., Li E., Serrano M., Millar S., Hannon G., Blasco M.A. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat. Struct. Mol. Biol. 2008, 15(3):268-279.
3. Boettger T., Beetz N., Kostin S., Schneider J., Krüger M., Hein L., Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. The Journal of Clinical Investigation 2009, 119(9):2634-2647.
4. Bonauer A., Carmona G., Iwasaki M., Mione M., Koyanagi M., Fischer A., Burchfield J., Fox H., Doebele C., Ohtani K., Chavakis E., Potente M., Tjwa M., Urbich C., Zeiher A.M., Dimmeler S. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 2009, 324(5935):1710-1713.
5. Brons I.G., Smithers L.E., Trotter M.W., Rugg-Gunn P., Sun B., de Sousa Chuva, Lopes S.M., Howlett S.K., Clarkson A., Ahrlund-Richter L., Pedersen R.A., Vallier L. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007, 448(7150):191-195.
6. Caporali A., Meloni M., Völlenkle C., Bonci D., Sala-Newby G.B., Addis R., Spinetti G., Losa S., Masson R., Baker A.H., Agami R., le Sage C., Condorelli G., Madeddu P., Martelli F., Emanueli C. Deregulation of microRNA-503 Contributes to Diabetes Mellitus -Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia / Clinical Perspective. Circulation 2011, 123(3):282-291.
7. Carmeliet P., Jain R.K. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 473(7347):298-307.
8. Chang T.-C., Zeitels L.R., Hwang H.-W., Chivukula R.R., Wentzel E.A., Dews M., Jung J., Gao P., Dang C.V., Beer M.A., Thomas-Tikhonenko A., Mendell J.T. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proceedings of the National Academy of Sciences 2009, 106(9):3384-3389.
9. Chen Y., Gorski D.H. Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood 2008, 111(3):1217-1226.
10. Chen J.-F., Mandel E.M., Thomson J.M., Wu Q., Callis T.E., Hammond S.M., Conlon F.L., Wang D.-Z. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nature Genetics 2006, 38(2):228-233.
11. Chen X., Xu H., Yuan P., Fang F., Huss M., Vega V.B., Wong E., Orlov Y.L., Zhang W., Jiang J., Loh Y.-H., Yeo H.C., Yeo Z.X., Narang V., Govindarajan K.R., Leong B., Shahab A., Ruan Y., Bourque G., Sung W.-K., Clarke N.D., Wei C.-L., Ng H.-H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008, 133(6):1106-1117.
12. Condorelli G., Latronico M.V.G., Dorn G.W. MicroRNAs in heart disease: putative novel therapeutic targets?. European Heart Journal 2010, 31(6):649-658.
13. Cordes K.R., Sheehy N.T., White M.P., Berry E.C., Morton S.U., Muth A.N., Lee T.-H., Miano J.M., Ivey K.N., Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 2009, 460(7256):705-710.
14. Davis B.N., Hilyard A.C., Nguyen P.H., Lagna G., Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. Journal of Biological Chemistry 2009, 284(6):3728-3738.
15. Denli A.M., Tops B.B.J., Plasterk R.H.A., Ketting R.F., Hannon G.J. Processing of primary microRNAs by the microprocessor complex. Nature 2004, 432(7014):231-235.
16. Dews M., Homayouni A., Yu D., Murphy D., Sevignani C., Wentzel E., Furth E.E., Lee W.M., Enders G.H., Mendell J.T., Thomas-Tikhonenko A. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nature Genetics 2006, 38(9):1060-1065.
17. Doebele C., Bonauer A., Fischer A., Scholz A., Reiss Y., Urbich C., Hofmann W.-K., Zeiher A.M., Dimmeler S. Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 2010, 115(23):4944-4950.
18. Elia L., Quintavalle M., Zhang J., Contu R., Cossu L., Latronico M.V., Peterson K.L., Indolfi C., Catalucci D., Chen J., Courtneidge S.A., Condorelli G. The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death and Differentiation 2009, 16(12):1590-1598.
19. Fasanaro P., D'Alessandra Y., Di Stefano V., Melchionna R., Romani S., Pompilio G., Capogrossi M.C., Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-A3. Journal of Biological Chemistry 2008, 283(23):15878-15883.
20. Feldman N., Gerson A., Fang J., Li E., Zhang Y., Shinkai Y., Cedar H., Bergman Y. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat. Cell. Biol. 2006, 8(2):188-194.
21. Fish J.E., Santoro M.M., Morton S.U., Yu S., Yeh R.-F., Wythe J.D., Ivey K.N., Bruneau B.G., Stainier D.Y.R., Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Developmental Cell 2008, 15(2):272-284.
22. Giraldez A.J., Cinalli R.M., Glasner M.E., Enright A.J., Thomson J.M., Baskerville S., Hammond S.M., Bartel D.P., Schier A.F. MicroRNAs regulate brain morphogenesis in zebrafish. Science 2005, 308(5723):833-838.
23. Greer Card D.A., Hebbar P.B., Li L., Trotter K.W., Komatsu Y., Mishina Y., Archer T.K. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Molecular and Cellular Biology 2008, 28(20):6426-6438.
24. Gregory R.I., Yan K.-p., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R. The microprocessor complex mediates the genesis of microRNAs. Nature 2004, 432(7014):235-240.
25. Guo H., Ingolia N.T., Weissman J.S., Bartel D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010, 466(7308):835-840.
26. Harris T.A., Yamakuchi M., Ferlito M., Mendell J.T., Lowenstein C.J. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proceedings of the National Academy of Sciences 2008, 105(5):1516-1521.
27. Heng J.-C.D., Ng H.-H. Transcriptional regulation in embryonic stem cells. The Cell Biology of Stem Cells 2010, vol. 695:76-91. Springer, US. E. Meshorer, K. Plath (Eds.).
28. Hosoda T., Zheng H., Cabral-da-Silva M., Sanada F., Ide-Iwata N., Ogórek B., Ferreira-Martins J., Arranto C., D'Amario D., del Monte F., Urbanek K., D'Alessandro D.A., Michler R.E., Anversa P., Rota M., Kajstura J., Leri A. Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism / Clinical Perspective. Circulation 2011, 123(12):1287-1296.
29. Houbaviy H.B., Murray M.F., Sharp P.A. Embryonic stem cell-specific microRNAs. Developmental Cell 2003, 5(2):351-358.
30. Huang H., Xie C., Sun X., Ritchie R.P., Zhang J., Chen Y.E. miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation. Journal of Biological Chemistry 2010, 285(13):9383-9389.
31. Huntzinger E., Izaurralde E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nature Reviews Genetics 2011, 12(2):99-110.
32. Hurst D.R., Edmonds M.D., Scott G.K., Benz C.C., Vaidya K.S., Welch D.R. Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Research 2009, 69(4):1279-1283.
33. Ivey K.N., Muth A., Arnold J., King F.W., Yeh R.F., Fish J.E., Hsiao E.C., Schwartz R.J., Conklin B.R., Bernstein H.S., Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2008, 2(3):219-229.
34. Judson R.L., Babiarz J.E., Venere M., Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat. Biotech. 2009, 27(5):459-461.
35. Kane N.M., Meloni M., Spencer H.L., Craig M.A., Strehl R., Milligan G., Houslay M.D., Mountford J.C., Emanueli C., Baker A.H. Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology 2010, 30(7):1389-1397.
36. Kanellopoulou C., Muljo S.A., Kung A.L., Ganesan S., Drapkin R., Jenuwein T., Livingston D.M., Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes & Development 2005, 19(4):489-501.
37. Kashyap V., Rezende N.C., Scotland K.B., Shaffer S.M., Persson J.L., Gudas L.J., Mongan N.P. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the nanog, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells and Development 2009, 18(7):1093-1108.
38. Kazenwadel J., Michael M.Z., Harvey N.L. Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood 2010, 116(13):2395-2401.
39. Kim K.-S., Kim J.S., Lee M.R., Jeong H.S., Kim J. A study of microRNAs in silico and in vivo: emerging regulators of embryonic stem cells. FEBS Journal 2009, 276(8):2140-2149.
40. Knight S.W., Bass B.L. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 2001, 293(5538):2269-2271.
41. Kuhn A.R., Schlauch K., Lao R., Halayko A.J., Gerthoffer W.T., Singer C.A. MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype. American Journal of Respiratory Cell and Molecular Biology 2010, 42(4):506-513.
42. Kwon C., Han Z., Olson E.N., Srivastava D. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(52):18986-18991.
43. Laflamme M.A., Murry C.E. Heart regeneration. Nature 2011, 473(7347):326-335.
44. Lai M., Wendy-Yeo W., Ramasamy R., Nordin N., Rosli R., Veerakumarasivam A., Abdullah S. Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. Journal of Assisted Reproduction and Genetics 2011, 1-11.
45. Lakshmipathy U., Love B., Goff L.A., Jörnsten R., Graichen R., Hart R.P., Chesnut J.D. MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells. Stem Cells and Development 2007, 16(6):1003-1016.
46. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., Lin C., Socci N.D., Hermida L., Fulci V., Chiaretti S., Foà R., Schliwka J., Fuchs U., Novosel A., Müller R.-U., Schermer B., Bissels U., Inman J., Phan Q., Chien M., Weir D.B., Choksi R., De Vita G., Frezzetti D., Trompeter H.-I., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler C.E., Nagle J.W., Ju J., Papavasiliou F.N., Benzing T., Lichter P., Tam W., Brownstein M.J., Bosio A., Borkhardt A., Russo J.J., Sander C., Zavolan M., Tuschl T. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007, 129(7):1401-1414.
47. Larsson E., Fredlund Fuchs P., Heldin J., Barkefors I., Bondjers C., Genove G., Arrondel C., Gerwins P., Kurschat C., Schermer B., Benzing T., Harvey S., Kreuger J., Lindahl P. Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Medicine 2009, 1(11):108.
48. Laurent L.C., Chen J., Ulitsky I., Mueller F.-J., Lu C., Shamir R., Fan J.-B., Loring J.F. Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell Signature Dominated by a Single Seed Sequence. Stem Cells 2008, 26(6):1506-1516.
49. Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Radmark O., Kim S., Kim V.N. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003, 425(6956):415-419.
50. Lee D.Y., Deng Z., Wang C.-H., Yang B.B. MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proceedings of the National Academy of Sciences 2007, 104(51):20350-20355.
51. Lin C.-H., Jackson A.L., Guo J., Linsley P.S., Eisenman R.N. Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO Journal 2009, 28(20):3157-3170.
52. Lin S.-L., Chang D.C., Lin C.-H., Ying S.-Y., Leu D., Wu D.T.S. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Research 2011, 39(3):1054-1065.
53. Liu N., Bezprozvannaya S., Williams A.H., Qi X., Richardson J.A., Bassel-Duby R., Olson E.N. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes & Development 2008, 22(23):3242-3254.
54. Lund E., Guttinger S., Calado A., Dahlberg J.E., Kutay U. Nuclear export of microRNA precursors. Science 2004, 303(5654):95-98.
55. Marson A., Levine S.S., Cole M.F., Frampton G.M., Brambrink T., Johnstone S., Guenther M.G., Johnston W.K., Wernig M., Newman J., Calabrese J.M., Dennis L.M., Volkert T.L., Gupta S., Love J., Hannett N., Sharp P.A., Bartel D.P., Jaenisch R., Young R.A. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008, 134(3):521-533.
56. Matsa E., Rajamohan D., Dick E., Young L., Mellor I., Staniforth A., Denning C. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. European Heart Journal 2011, 32(8):952-962.
57. Melton C., Blelloch R. MicroRNA regulation of embryonic stem cell self-renewal and differentiation. Advances in Experimental Medicine and Biology 2010, 695:105-117.
58. Mendell J.T. miRiad Roles for the miR-17-92 Cluster in Development and Disease. Cell 2008, 133(2):217-222.
59. Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J.-i., Matoba R., Ko M.S.H., Niwa H. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Molecular and Cellular Biology 2006, 26(20):7772-7782.
60. Nicoli S., Standley C., Walker P., Hurlstone A., Fogarty K.E., Lawson N.D. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature 2010, 464(7292):1196-1200.
61. O'Donnell K.A., Wentzel E.A., Zeller K.I., Dang C.V., Mendell J.T. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005, 435(7043):839-843.
62. Ohtsuka S., Dalton S. Molecular and biological properties of pluripotent embryonic stem cells. Gene Therapy 2008, 15(2):74-81.
63. Pan Y., Balazs L., Tigyi G., Yue J. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochemical and Biophysical Research Communications 2011, 408(3):369-374.
64. Qi J., Yu J.Y., Shcherbata H.R., Mathieu J., Wang A.J., Seal S., Zhou W., Stadler B.M., Bourgin D., Wang L., Nelson A., Ware C., Raymond C., Lim L.P., Magnus J., Ivanovska I., Diaz R., Ball A., Cleary M.A., Ruohola-Baker H. MicroRNAs regulate human embryonic stem cell division. Cell Cycle 2009, 8(22):3729-3741.
65. Qiu C., Ma Y., Wang J., Peng S., Huang Y. Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Research 2010, 38(4):1240-1248.
66. Rao P.K., Kumar R.M., Farkhondeh M., Baskerville S., Lodish H.F. Myogenic factors that regulate expression of muscle-specific microRNAs. Proceedings of the National Academy of Sciences 2006, 103(23):8721-8726.
67. Reddy K., Zhou Z., Schadler K., Jia S.-F., Kleinerman E.S. Bone marrow subsets differentiate into endothelial cells and pericytes contributing to ewing's tumor vessels. Molecular Cancer Research 2008, 6(6):929-936.
68. Rybak A., Fuchs H., Smirnova L., Brandt C., Pohl E.E., Nitsch R., Wulczyn F.G. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nature Cell Biology 2008, 10(8):987-993.
69. Sengupta S., Nie J., Wagner R.J., Yang C., Stewart R., Thomson J.A. MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells 2009, 27(7):1524-1528.
70. Sinkkonen L., Hugenschmidt T., Berninger P., Gaidatzis D., Mohn F., Artus-Revel C.G., Zavolan M., Svoboda P., Filipowicz W. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nature Structural and Molecular Biology 2008, 15(3):259-267.
71. Sluijter J.P.G., van Mil A., van Vliet P., Metz C.H.G., Liu J., Doevendans P.A., Goumans M.-J. MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2010, 30(4):859-868.
72. Smale S.T. Pioneer factors in embryonic stem cells and differentiation. Current Opinion in Genetics & Development 2010, 20(5):519-526.
73. Small E.M., Olson E.N. Pervasive roles of microRNAs in cardiovascular biology. Nature 2011, 469(7330):336-342.
74. Smith K.N., Singh A.M., Dalton S. Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell 2010, 7(3):343-354.
75. Stadler B., Ivanovska I., Mehta K., Song S., Nelson A., Tan Y., Mathieu J., Darby C., Blau C.A., Ware C., Peters G., Miller D.G., Shen L., Cleary M.A., Ruohola-Baker H. Characterization of microRNAs involved in embryonic stem cell states. Stem Cells and Development 2010, 19(7):935-950.
76. Suarez Y., Fernandez-Hernando C., Pober J.S., Sessa W.C. Dicer dependent MicroRNAs regulate gene expression and functions in human endothelial cells. Circulation Research 2007, 100(8):1164-1173.
77. Suárez Y., Fernández-Hernando C., Yu J., Gerber S.A., Harrison K.D., Pober J.S., Iruela-Arispe M.L., Merkenschlager M., Sessa W.C. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proceedings of the National Academy of Sciences 2008, 105(37):14082-14087.
78. Suh M.-R., Lee Y., Kim J.Y., Kim S.-K., Moon S.-H., Lee J.Y., Cha K.-Y., Chung H.M., Yoon H.S., Moon S.Y., Kim V.N., Kim K.-S. Human embryonic stem cells express a unique set of microRNAs. Developmental Biology 2004, 270(2):488-498.
79. Taguchi A., Yanagisawa K., Tanaka M., Cao K., Matsuyama Y., Goto H., Takahashi T. Identification of hypoxia-inducible factor-1α as a novel target for miR-17-92 microrna cluster. Cancer Research 2008, 68(14):5540-5545.
80. Takaya T., Ono K., Kawamura T., Takanabe R., Kaichi S., Morimoto T., Wada H., Kita T., Shimatsu A., Hasegawa K. MicroRNA-1 and microRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. Circulation Journal 2009, 73(8):1492-1497.
81. Tay Y., Zhang J., Thomson A.M., Lim B., Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008, 455(7216):1124-1128.
82. van Rooij E., Olson E.N. MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. The Journal of Clinical Investigation 2007, 117(9):2369-2376.
83. Ventura A., Young A.G., Winslow M.M., Lintault L., Meissner A., Erkeland S.J., Newman J., Bronson R.T., Crowley D., Stone J.R., Jaenisch R., Sharp P.A., Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 92 family of miRNA clusters. Cell 2008, 132(5):875-886.
84. Viswanathan S.R., Daley G.Q., Gregory R.I. Selective blockade of microRNA processing by Lin28. Science 2008, 320(5872):97-100.
85. Wakioka T., Sasaki A., Kato R., Shouda T., Matsumoto A., Miyoshi K., Tsuneoka M., Komiya S., Baron R., Yoshimura A. Spred is a sprouty-related suppressor of Ras signalling. Nature 2001, 412(6847):647-651.
86. Wang Y., Medvid R., Melton C., Jaenisch R., Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nature Genetics 2007, 39(3):380-385.
87. Wang S., Aurora A.B., Johnson B.A., Qi X., McAnally J., Hill J.A., Richardson J.A., Bassel-Duby R., Olson E.N. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Developmental Cell 2008, 15(2):261-271.
88. Wang Y., Baskerville S., Shenoy A., Babiarz J.E., Baehner L., Blelloch R. Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nature Genetics 2008, 40(12):1478-1483.
89. Weber F., Teresi R.E., Broelsch C.E., Frilling A., Eng C. A limited set of human microRNA is deregulated in follicular thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 2006, 91(9):3584-3591.
90. Wellner U., Schubert J., Burk U.C., Schmalhofer O., Zhu F., Sonntag A., Waldvogel B., Vannier C., Darling D., Hausen A.z., Brunton V.G., Morton J., Sansom O., Schuler J., Stemmler M.P., Herzberger C., Hopt U., Keck T., Brabletz S., Brabletz T. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biology 2009, 11(12):1487-1495.
91. Wilson K.D., Venkatasubrahmanyam S., Jia F., Sun N., Butte A.J., Wu J.C. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells and Development 2009, 18(5):749-757.
92. Wilson K.D., Hu S., Venkatasubrahmanyam S., Fu J.-D., Sun N., Abilez O.J., Baugh J.J.A., Jia F., Ghosh Z., Li R.A., Butte A.J., Wu J.C. Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells/clinical perspective. Circulation. Cardiovascular Genetics 2010, 3(5):426-435.
93. Würdinger T., Tannous B.A., Saydam O., Skog J., Grau S., Soutschek J., Weissleder R., Breakefield X.O., Krichevsky A.M. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 2008, 14(5):382-393.
94. Xie C., Huang H., Sun X., Guo Y., Hamblin M., Ritchie R.P., Garcia-Barrio M.T., Zhang J., Chen Y.E. MicroRNA-1 regulates smooth muscle cell differentiation by repressing kruppel-like factor 4. Stem Cells and Development 2011, 20(2):205-210.
95. Xin M., Small E.M., Sutherland L.B., Qi X., McAnally J., Plato C.F., Richardson J.A., Bassel-Duby R., Olson E.N. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes & Development 2009, 23(18):2166-2178.
96. Yang W.J., Yang D.D., Na S., Sandusky G.E., Zhang Q., Zhao G. Dicer is required for embryonic angiogenesis during mouse development. Journal of Biological Chemistry 2005, 280(10):9330-9335.
97. Zhang J., Lian Q., Zhu G., Zhou F., Sui L., Tan C., Mutalif R.A., Navasankari R., Zhang Y., Tse H.-F., Stewart C.L., Colman A. A human iPSC model of hutchinson gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell 2011, 8(1):31-45.
98. Zhao Y., Ransom J.F., Li A., Vedantham V., von Drehle M., Muth A.N., Tsuchihashi T., McManus M.T., Schwartz R.J., Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007, 129(2):303-317.
99. Zhao T., Zhang Z.-N., Rong Z., Xu Y. Immunogenicity of induced pluripotent stem cells. Nature 2011, 474(7350):212-215.
100. Zhou Q., Gallagher R., Ufret-Vincenty R., Li X., Olson E.N., Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proceedings of the National Academy of Sciences 2011, 108(20):8287-8292.