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Volumn 44, Issue 5, 2011, Pages 643-652

All-trans retinoic acid loaded block copolymer nanoparticles efficiently induce cellular differentiation in HL-60 cells

Author keywords

Acute Promyelocytic Leukemia; All trans retinoic acid; Differentiation therapy; PEG PC; PEG PLA; Polymer nanoparticles

Indexed keywords

CD11B ANTIGEN; COPOLYMER; MACROGOL; NANOPARTICLE; POLYCAPROLACTONE; POLYLACTIDE; RETINOIC ACID;

EID: 82155166242     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.10.014     Document Type: Article
Times cited : (11)

References (52)
  • 1
    • 0028836169 scopus 로고
    • Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3, retinoic acid and DMSO
    • D. Brackman, F. Lund-Johansen, and D. Aarskog Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3, retinoic acid and DMSO Leuk. Res. 19 1995 57 64
    • (1995) Leuk. Res. , vol.19 , pp. 57-64
    • Brackman, D.1    Lund-Johansen, F.2    Aarskog, D.3
  • 4
    • 0033974883 scopus 로고    scopus 로고
    • Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia
    • X. Cai, Y.-L. Shen, Q. Zhu, P.-M. Jia, Y. Yu, L. Zhou, Y. Huang, J.-W. Zhang, S.-M. Xiong, S.-J. Chen, Z.-Y. Wang, Z. Chen, and G.-Q. Chen Arsenic trioxide-induced apoptosis and differentiation are associated, respectively, with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia Leukemia 14 2000 262 270 (Pubitemid 30095381)
    • (2000) Leukemia , vol.14 , Issue.2 , pp. 262-270
    • Cai, X.1    Shen, Y.-L.2    Zhu, Q.3    Jia, P.-M.4    Yu, Y.5    Zhou, L.6    Huang, Y.7    Zhang, J.-W.8    Xiong, S.-M.9    Chen, S.-J.10    Wang, Z.-Y.11    Chen, Z.12    Chen, G.-Q.13
  • 5
    • 0025201879 scopus 로고
    • All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results
    • S. Castaigne, C. Chomienne, M.T. Daniel, P. Ballerini, R. Berger, P. Fenaux, and L. Degos All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results Blood 76 1990 1704 1709
    • (1990) Blood , vol.76 , pp. 1704-1709
    • Castaigne, S.1    Chomienne, C.2    Daniel, M.T.3    Ballerini, P.4    Berger, R.5    Fenaux, P.6    Degos, L.7
  • 6
    • 0035857708 scopus 로고    scopus 로고
    • Long-term delivery of all-trans-retinoic acid using biodegradable PLLA/PEG-PLLA blended microspheres
    • DOI 10.1016/S0378-5173(00)00676-1, PII S0378517300006761
    • Y. Choi, S.Y. Kim, S.H. Kim, K.-S. Lee, C. Kim, and Y. Byun Long-term delivery of all-trans-retinoic acid using biodegradable PLLA/PEG-PLLA blended microspheres Int. J. Pharm. 215 2001 67 81 (Pubitemid 32206605)
    • (2001) International Journal of Pharmaceutics , vol.215 , Issue.1-2 , pp. 67-81
    • Choi, Y.1    Kim, S.Y.2    Kim, S.H.3    Lee, K.-S.4    Kim, C.5    Byun, Y.6
  • 7
    • 0020663584 scopus 로고
    • Differentiation of promyelocytic (HL-60) cells into mature granulocytes: Mitochondrial specific rhodamine 123 fluorescence
    • DOI 10.1083/jcb.96.1.94
    • J.M. Collins, and K.A. Foster Differentiation of promyelocytic (HL-60) cells into mature granulocytes: mitochondrial-specific rhodamine 123 fluorescence J. Cell Biol. 96 1983 94 99 (Pubitemid 13155565)
    • (1983) Journal of Cell Biology , vol.96 , Issue.1 , pp. 94-99
    • Collins, J.M.1    Foster, K.A.2
  • 8
    • 0023605430 scopus 로고
    • The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression
    • S. Collins The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression Blood 70 1987 1233 1244 (Pubitemid 18026122)
    • (1987) Blood , vol.70 , Issue.5 , pp. 1233-1244
    • Collins, S.J.1
  • 9
    • 0018918247 scopus 로고
    • Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murine leukemia cells
    • DOI 10.1002/ijc.2910250208
    • S.J. Collins, A. Bodner, R. Ting, and R.C. Gallo Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murine leukemia cells Int. J. Cancer 25 1980 213 218 (Pubitemid 10217394)
    • (1980) International Journal of Cancer , vol.25 , Issue.2 , pp. 213-218
    • Collins, S.J.1    Bodner, A.2    Ting, R.3    Gallo, R.C.4
  • 10
    • 0025880967 scopus 로고
    • Retinoids and their receptors in differentiation, embryogenesis, and neoplasia
    • L.M. De Luca Retinoids and their receptors in differentiation, embryogenesis, and neoplasia FASEB J. 5 1991 2924 2933 (Pubitemid 21905833)
    • (1991) FASEB Journal , vol.5 , Issue.14 , pp. 2924-2933
    • De Luca, L.M.1
  • 12
    • 0035872253 scopus 로고    scopus 로고
    • 3 or all-trans-retinoic acid
    • DOI 10.1006/excr.2001.5200
    • M.T. Drayson, R.H. Michell, J. Durham, and G. Brown Cell proliferation and CD11b expression are controlled independently during HL60 cell differentiation initiated by 1,25[α]-dihydroxyvitamin D3 or all-trans-retinoic acid Exp. Cell Res. 266 2001 126 134 (Pubitemid 32989049)
    • (2001) Experimental Cell Research , vol.266 , Issue.1 , pp. 126-134
    • Drayson, M.T.1    Michell, R.H.2    Durham, J.3    Brown, G.4
  • 13
    • 12544255422 scopus 로고    scopus 로고
    • Use of HL-60 cell line to measure opsonic capacity of pneumococcal antibodies
    • R.A. Fleck, S. Romero-Steiner, and M.H. Nahm Use of HL-60 cell line to measure opsonic capacity of pneumococcal antibodies Clin. Diagn. Lab. Immunol. 12 2005 19 27
    • (2005) Clin. Diagn. Lab. Immunol. , vol.12 , pp. 19-27
    • Fleck, R.A.1    Romero-Steiner, S.2    Nahm, M.H.3
  • 14
    • 0037442128 scopus 로고    scopus 로고
    • The mitochondrial network of human neutrophils: Role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis
    • G. Fossati, D.A. Moulding, D.G. Spiller, R.J. Moots, M.R.H. White, and S.W. Edwards The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis J. Immunol. 170 2003 1964 1972 (Pubitemid 36197416)
    • (2003) Journal of Immunology , vol.170 , Issue.4 , pp. 1964-1972
    • Fossati, G.1    Moulding, D.A.2    Spiller, D.G.3    Moots, R.J.4    White, M.R.H.5    Edwards, S.W.6
  • 15
    • 0344394175 scopus 로고    scopus 로고
    • Retinoids in cancer therapy and chemoprevention: Promise meets resistance
    • DOI 10.1038/sj.onc.1206936, Drug Resistance
    • S.J. Freemantle, M.J. Spinella, and E. Dmitrovsky Retinoids in cancer therapy and chemoprevention: promise meets resistance Oncogene 22 2003 7305 7315 (Pubitemid 37487162)
    • (2003) Oncogene , vol.22 , pp. 7305-7315
    • Freemantle, S.J.1    Spinella, M.J.2    Dmitrovsky, E.3
  • 18
    • 0028279223 scopus 로고
    • Determination of orally administered all-trans-retinoic acid in human plasma by high-performance liquid chromatography
    • DOI 10.1016/0378-4347(94)00080-8
    • G. Guiso, A. Rambaldi, B. Dimitrova, A. Biondi, and S. Caccia Determination of orally administered all-trans-retinoic acid in human plasma by high-performance liquid chromatography J. Chromatogr. B 656 1994 239 244 (Pubitemid 24190731)
    • (1994) Journal of Chromatography B: Biomedical Applications , vol.656 , Issue.1 , pp. 239-244
    • Guiso, G.1    Rambaldi, A.2    Dimitrova, B.3    Biondi, A.4    Caccia, S.5
  • 19
    • 34548140496 scopus 로고    scopus 로고
    • An epigenetic perspective on the free radical theory of development
    • DOI 10.1016/j.freeradbiomed.2007.06.027, PII S0891584907004601
    • M.J. Hitchler, and F.E. Domann An epigenetic perspective on the free radical theory of development Free Rad. Biol. Med. 43 2007 1023 1036 (Pubitemid 47302657)
    • (2007) Free Radical Biology and Medicine , vol.43 , Issue.7 , pp. 1023-1036
    • Hitchler, M.J.1    Domann, F.E.2
  • 20
    • 15044345225 scopus 로고    scopus 로고
    • Accelerated photostability study of tretinoin and isotretinoin in liposome formulations
    • DOI 10.1016/j.ijpharm.2005.01.012
    • G. Ioele, E. Cione, A. Risoli, G. Genchi, and G. Ragno Accelerated photostability study of tretinoin and isotretinoin in liposome formulations Int. J. Pharm. 293 2005 251 260 (Pubitemid 40381097)
    • (2005) International Journal of Pharmaceutics , vol.293 , Issue.1-2 , pp. 251-260
    • Ioele, G.1    Cione, E.2    Risoli, A.3    Genchi, G.4    Ragno, G.5
  • 21
    • 1542298890 scopus 로고    scopus 로고
    • All-trans-retinoic acid release from core-shell type nanoparticles of poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymer
    • DOI 10.1016/j.ijpharm.2003.12.012, PII S0378517303007014
    • Y.-I. Jeong, M.-K. Kang, H.-S. Sun, S.-S. Kang, H.-W. Kim, K.-S. Moon, K.-J. Lee, S.-H. Kim, and S. Jung All-trans-retinoic acid release from core-shell type nanoparticles of poly([]-caprolactone)/poly(ethylene glycol) diblock copolymer Int. J. Pharm. 273 2004 95 107 (Pubitemid 38317044)
    • (2004) International Journal of Pharmaceutics , vol.273 , Issue.1-2 , pp. 95-107
    • Jeong, Y.-I.1    Kang, M.-K.2    Sun, H.-S.3    Kang, S.-S.4    Kim, H.-W.5    Moon, K.-S.6    Lee, K.-J.7    Kim, S.-H.8    Jung, S.9
  • 22
    • 1642541103 scopus 로고    scopus 로고
    • Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds
    • DOI 10.1615/CritRevTherDrugCarrierSyst.v20.i5.20
    • G.S. Kwon Polymeric micelles for delivery of poorly water-soluble compounds Crit. Rev. Ther. Drug Carrier Syst. 20 2003 357 403 (Pubitemid 38129592)
    • (2003) Critical Reviews in Therapeutic Drug Carrier Systems , vol.20 , Issue.5 , pp. 357-403
    • Kwon, G.S.1
  • 24
    • 0024990349 scopus 로고
    • Induction of the respiratory burst in HL-60 cells: Correlation of function and protein expression
    • R. Levy, D. Rotrosen, O. Nagauker, T.L. Leto, and H.L. Malech Induction of the respiratory burst in HL-60 cells: correlation of function and protein expression J. Immunol. 145 1990 2595 2601 (Pubitemid 20374584)
    • (1990) Journal of Immunology , vol.145 , Issue.8 , pp. 2595-2601
    • Levy, R.1    Rotrosen, D.2    Nagauker, O.3    Leto, T.L.4    Malech, H.L.5
  • 25
    • 7444255422 scopus 로고    scopus 로고
    • Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders
    • DOI 10.1016/j.jconrel.2004.07.032, PII S0168365904003773
    • S.-J. Lim, M.-K. Lee, and C.-K. Kim Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders J. Cont. Rel. 100 2004 53 61 (Pubitemid 39445985)
    • (2004) Journal of Controlled Release , vol.100 , Issue.1 , pp. 53-61
    • Lim, S.-J.1    Lee, M.-K.2    Kim, C.-K.3
  • 26
    • 0029796637 scopus 로고    scopus 로고
    • Retinoids in cancer chemoprevention
    • R. Lotan Retinoids in cancer chemoprevention FASEB J. 10 1996 1031 1039 (Pubitemid 26285979)
    • (1996) FASEB Journal , vol.10 , Issue.9 , pp. 1031-1039
    • Lotan, R.1
  • 27
    • 0037006602 scopus 로고    scopus 로고
    • Niosomes as carriers for tretinoin. I. Preparation and properties
    • DOI 10.1016/S0378-5173(01)00971-1, PII S0378517301009711
    • M. Manconi, C. Sinico, D. Valenti, G. Loy, and A.M. Fadda Niosomes as carriers for tretinoin. I. Preparation and properties Int. J. Pharm. 234 2002 237 248 (Pubitemid 34142628)
    • (2002) International Journal of Pharmaceutics , vol.234 , Issue.1-2 , pp. 237-248
    • Manconi, M.1    Sinico, C.2    Valenti, D.3    Loy, G.4    Fadda, A.M.5
  • 28
    • 0025139398 scopus 로고
    • HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis
    • S.J. Martin, J.G. Bradley, and T.G. Cotter HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis Clin. Exp. Immunol. 79 1990 448 453 (Pubitemid 20082275)
    • (1990) Clinical and Experimental Immunology , vol.79 , Issue.3 , pp. 448-453
    • Martin, S.J.1    Bradley, J.G.2    Cotter, T.G.3
  • 29
    • 0037071405 scopus 로고    scopus 로고
    • Differentiation induction as a treatment for hematologic malignancies
    • DOI 10.1038/sj.onc.1205328
    • W.H. Miller Jr., and S. Waxman Differentiation induction as a treatment for hematologic malignancies Oncogene 21 2002 3496 3506 (Pubitemid 34587718)
    • (2002) Oncogene , vol.21 , pp. 3496-3506
    • Miller Jr., W.H.1    Waxman, S.2
  • 30
    • 77649185802 scopus 로고    scopus 로고
    • NB4 cells treated with all-trans retinoic acid generate toxic reactive oxygen species that cause endothelial hyperpermeability
    • T. Miyoshi, T. Arai, K. Yamashita, M. Sasada, and T. Uchiyama NB4 cells treated with all-trans retinoic acid generate toxic reactive oxygen species that cause endothelial hyperpermeability Leuk. Res. 34 2010 373 378
    • (2010) Leuk. Res. , vol.34 , pp. 373-378
    • Miyoshi, T.1    Arai, T.2    Yamashita, K.3    Sasada, M.4    Uchiyama, T.5
  • 31
    • 0026536835 scopus 로고
    • Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: Implications for relapse and retinoid ''resistance" in patients with acute promyelocytic leukemia
    • J. Muindi, S.R. Frankel, W.H. Miller Jr., A. Jakubowski, D.A. Scheinberg, C.W. Young, E. Dmitrovsky, and R.P. Warrell Jr. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid ''resistance" in patients with acute promyelocytic leukemia Blood 79 1992 299 303
    • (1992) Blood , vol.79 , pp. 299-303
    • Muindi, J.1    Frankel, S.R.2    Miller, Jr.W.H.3    Jakubowski, A.4    Scheinberg, D.A.5    Young, C.W.6    Dmitrovsky, E.7    Warrell, Jr.R.P.8
  • 32
    • 0028203794 scopus 로고
    • Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells
    • L. Naumovski, and M. Cleary Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells Blood 83 1994 2261 2267 (Pubitemid 24112739)
    • (1994) Blood , vol.83 , Issue.8 , pp. 2261-2267
    • Naumovski, L.1    Cleary, M.L.2
  • 33
    • 0021365851 scopus 로고
    • Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line
    • P.E. Newburger, C. Speier, N. Borregaard, C.E. Walsh, J.C. Whitin, and E.R. Simons Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line J. Biol. Chem. 259 1984 3771 3776 (Pubitemid 14173417)
    • (1984) Journal of Biological Chemistry , vol.259 , Issue.6 , pp. 3771-3776
    • Newburger, P.E.1    Speier, C.2    Borregaard, N.3
  • 35
    • 77957966086 scopus 로고    scopus 로고
    • Oxidative stress enhances granulocytic differentiation in HL 60 cells, an acute promyelocytic leukemia cell line
    • T. Ogino, M. Ozaki, and A. Matsukawa Oxidative stress enhances granulocytic differentiation in HL 60 cells, an acute promyelocytic leukemia cell line Free Rad. Res. 44 2010 1328 1337
    • (2010) Free Rad. Res. , vol.44 , pp. 1328-1337
    • Ogino, T.1    Ozaki, M.2    Matsukawa, A.3
  • 36
    • 11244302679 scopus 로고    scopus 로고
    • Retinoid-induced apoptosis in HL-60 cells is associated with nucleolin down-regulation and destabilization of Bcl-2 mRNA
    • DOI 10.1124/mol.104.006080
    • Y. Otake, T.K. Sengupta, S. Bandyopadhyay, E.K. Spicer, and D.J. Fernandes Retinoid-Induced Apoptosis in HL-60 Cells Is Associated with Nucleolin Down-Regulation and Destabilization of Bcl-2 mRNA Mol. Pharmacol. 67 2005 319 326 (Pubitemid 40069993)
    • (2005) Molecular Pharmacology , vol.67 , Issue.1 , pp. 319-326
    • Otake, Y.1    Sengupta, T.K.2    Bandyopadhyay, S.3    Spicer, E.K.4    Fernandes, D.J.5
  • 37
    • 0038771201 scopus 로고    scopus 로고
    • Rhodamine B as a mitochondrial probe for measurement and monitoring of mitochondrial membrane potential in drug-sensitive and -resistant cells
    • DOI 10.1016/S0165-022X(03)00032-0
    • P. Reungpatthanaphong, S. Dechsupa, J. Meesungnoen, C. Loetchutinat, and S. Mankhetkorn Rhodamine B as a mitochondrial probe for measurement and monitoring of mitochondrial membrane potential in drug-sensitive and -resistant cells J. Biochem. Biophys. Methods 57 2003 1 16 (Pubitemid 36776612)
    • (2003) Journal of Biochemical and Biophysical Methods , vol.57 , Issue.1 , pp. 1-16
    • Reungpatthanaphong, P.1    Dechsupa, S.2    Meesungnoen, J.3    Loetchutinat, C.4    Mankhetkorn, S.5
  • 40
    • 0032576692 scopus 로고    scopus 로고
    • Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
    • DOI 10.1038/35160
    • T. Rosse, R. Olivier, L. Monney, M. Rager, S. Conus, I. Fellay, B. Jansen, and C. Borner Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c Nature 391 1998 496 499 (Pubitemid 28086551)
    • (1998) Nature , vol.391 , Issue.6666 , pp. 496-499
    • Rosse, T.1    Olivier, R.2    Monney, L.3    Rager, M.4    Conus, S.5    Fellay, I.6    Jansen, B.7    Borner, C.8
  • 41
    • 0038171416 scopus 로고    scopus 로고
    • Neutrophil apoptosis pathways and their modifications in inflammation
    • DOI 10.1034/j.1600-065X.2003.00038.x
    • H.-U. Simon Neutrophil apoptosis pathways and their modifications in inflammation Immunol. Rev. 193 2003 101 110 (Pubitemid 36688044)
    • (2003) Immunological Reviews , vol.193 , pp. 101-110
    • Simon, H.-U.1
  • 42
    • 0027259417 scopus 로고
    • Antisense oligonucleotides to the p65 subunit of NF-κB block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes
    • J. Sokoloski, A. Sartorelli, C. Rosen, and R. Narayanan Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes Blood 82 1993 625 632 (Pubitemid 23206131)
    • (1993) Blood , vol.82 , Issue.2 , pp. 625-632
    • Sokoloski, J.A.1    Sartorelli, A.C.2    Rosen, C.A.3    Narayanan, R.4
  • 45
    • 0028865911 scopus 로고
    • Quantitative multiwell myeloid differentiation assay using dichlorodihydrofluorescein diacetate (H2DCF-DA) or dihydrorhodamine 123 (H2R123)
    • I.D. Trayner, A.P. Rayner, G.E. Freeman, and F. Farzaneh Quantitative multiwell myeloid differentiation assay using dichlorodihydrofluorescein diacetate (H2DCF-DA) or dihydrorhodamine 123 (H2R123) J. Immunol. Methods 186 1995 275 284
    • (1995) J. Immunol. Methods , vol.186 , pp. 275-284
    • Trayner, I.D.1    Rayner, A.P.2    Freeman, G.E.3    Farzaneh, F.4
  • 46
    • 26944452043 scopus 로고    scopus 로고
    • PEGylation, successful approach to drug delivery
    • DOI 10.1016/S1359-6446(05)03575-0, PII S1359644605035750
    • F.M. Veronese, and G. Pasut PEGylation, successful approach to drug delivery Drug Discov. Today 10 2005 1451 1458 (Pubitemid 41483874)
    • (2005) Drug Discovery Today , vol.10 , Issue.21 , pp. 1451-1458
    • Veronese, F.M.1    Pasut, G.2
  • 47
    • 0027448677 scopus 로고
    • Retinoid resistance in acute promyelocytic leukemia: New mechanisms, strategies, and implications
    • R.P. Warrell Jr. Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications Blood 82 1993 1949 1953 (Pubitemid 23293971)
    • (1993) Blood , vol.82 , Issue.7 , pp. 1949-1953
    • Warrell Jr., R.P.1
  • 49
    • 0342941158 scopus 로고    scopus 로고
    • Granulocytic differentiation of HL-60 cells results in spontaneous apoptosis mediated by increased caspase expression
    • DOI 10.1016/S0014-5793(97)00779-5, PII S0014579397007795
    • R.W.G. Watson, O.D. Rotstein, J. Parodo, R. Bitar, D. Hackam, and J.C. Marshall Granulocytic differentiation of HL-60 cells results in spontaneous apoptosis mediated by increased caspase expression FEBS Lett. 412 1997 603 609 (Pubitemid 27337118)
    • (1997) FEBS Letters , vol.412 , Issue.3 , pp. 603-609
    • William, R.1    Watson, G.2    Rotstein, O.D.3    Parodo, J.4    Bitar, R.5    Hackam, D.6    Marshall, J.C.7
  • 51
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • DOI 10.1126/science.275.5303.1129
    • J. Yang, X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.-I. Peng, D.P. Jones, and X. Wang Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked Science 275 1997 1129 1132 (Pubitemid 27097312)
    • (1997) Science , vol.275 , Issue.5303 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5    Cai, J.6    Peng, T.-I.7    Jones, D.P.8    Wang, X.9


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