Diclofenac topical solution compared with oral diclofenac: A pooled safety analysis

Journal of Pain Research

Volumn 4, Issue , 2011, Pages 159-167

  Roth, Sanford H ^a   Fuller, Philip ^b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b Medical Affairs   (United States)

Author keywords

Diclofenac; Gastropathy; Oral NSAIDs; Osteoarthritis; Topical NSAIDs

Indexed keywords

EID: 82155161124     PISSN: 11787090     EISSN: None     Source Type: Journal    
DOI: 10.2147/JPR.S20965     Document Type: Article

References (24)

1. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidencebased, expert consensus guidelines. Osteoarthr Cartil. 2008;16(2): 137-162.
2. Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthr Cartil. 2010;18(4):476-499.
3. National Collaborating Centre for Chronic Conditions. London: Royal College of Physicians; 2008. Osteoarthritis: National clinical guideline for care and management in adults. http://www.nice.org.uk/nicemedia/ pdf/CG059FullGuideline.pdf. Accessed May 5, 2010.
4. Lanas A, Tornero J, Zamorano JL. Assessment of gastrointestinal and cardiovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study. Ann Rheum Dis. 2010;69(8):1453-1458.
5. Roth SH. NSAID gastropathy. A new understanding. Arch Intern Med. 1996;156(15):1623-1628.
6. Roth SH. Nonsteroidal anti-inflammatory drug gastropathy. We started it-can we stop it. Arch Intern Med. 1986;146(6):1075-1076.
7. Teoh NC, Farrell GC. Hepatotoxicity associated with non-steroidal anti-inflammatory drugs. Clin Liver Dis. 2003;7(2):401-413.
8. Whelton A. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med. 1999;106(5B):13S-24S.
9. Moen MD. Topical diclofenac solution. Drugs. 2009;69(18):2621-2632.
10. Baer PA, Thomas LM, Shainhouse Z. Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]. BMC Musculoskelet Disord. 2005;6:44.
11. Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ. 2004;171(4): 333-338.
12. Roth SH, Shainhouse JZ. Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial. Arch Intern Med. 2004;164(18):2017-2023.
13. Tugwell PS, Wells GA, Shainhouse JZ. Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. J Rheumatol. 2004;31(10):2002-2012.
14. Simon LS, Grierson LM, Naseer Z, et al. Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. Pain. 2009;143(3):238-245.
15. Bellamy N. WOMAC Osteoarthritis Index User's Guide III. London, Ontario: London Health Sciences Centre; 1998.
16. Altman RD, Hochberg M, Murphy WA Jr, et al. Atlas of individual radiological features in osteoarthritis. Osteoarthr Cartil. 1995;3 Suppl A: 3-70.
17. Roth SH. Arthritis therapy: Back to the future (editorial) Arch Intern Med. 1987;147(1):36-37.
18. Emery P, Zeidler H, Kvien TK, et al. Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised doubleblind comparison. Lancet. 1999;354(9196):2106-2111.
19. Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000;343(21): 1520-1528.
20. Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352(11):1092-1102.
21. Lévesque LE, Brophy JM, Zhang B. The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults. Ann Intern Med. 2005;142(7):481-489.
22. Barthel HR, Haselwood D, Longley S 3rd, et al. Randomized controlled trial of diclofenac sodium gel in knee osteoarthritis. Semin Arthritis Rheum. 2009;39(3):203-212.
23. Baraf HS, Gold MS, Clark MB, et al. Safety and efficacy of topical diclofenac sodium 1% gel in knee osteoarthritis: a randomized controlled trial. Phys Sportsmed. 2010;38(2):19-28.
24. American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc. 2009;57(8): 1331-1346.