Clinical heterogeneity in patients with early-stage Parkinson's disease: A cluster analysis

Journal of Zhejiang University: Science B

Volumn 12, Issue 9, 2011, Pages 694-703

  Liu, Ping ^a   Feng, Tao ^a   Wang, Yong Jun ^a   Zhang, Xuan ^a   Chen, Biao ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cluster analysis; Heterogeneity; Parkinson's disease; Subtype

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CLUSTER ANALYSIS; DISEASE CLASSIFICATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PRIORITY JOURNAL; TREMOR;

ADULT; AGED; AGED, 80 AND OVER; CLUSTER ANALYSIS; DISEASE PROGRESSION; FEMALE; HUMANS; LEVODOPA; MALE; MIDDLE AGED; MODELS, STATISTICAL; PARKINSON DISEASE; PHENOTYPE; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 82055183880     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1100069     Document Type: Article

References (31)

1. Chaudhuri, K.R., Naidu, Y., 2008. Early Parkinson's disease and non-motor issues. J. Neurol., 255(s5):33-38. [doi: 10.1007/s00415-008-5006-1]
2. Chaudhuri, K.R., Healy, D.G., Schapira, A.H., 2006. Nonmotor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol., 5(3):235-245. [doi:10. 1016/S1474-4422(06)70373-8] (Pubitemid 43238347)
3. Everitt, B.S., Landau, S., Leese, M., 2001. Cluster Analysis, 4th Ed. Hodder Headline Group, London.
4. Fahn, S., Elton, R.L., Members of the UPDRS Development Committee, 1987. Unified Parkinson's Disease Rating Scale. In: Fahn, S., Marsden, C.D., Calne, D.B., Goldstein, M., (Eds.), Recent Developments in Parkinson's Disease. Vol. 2, McMillan Health Care Information, Florham Park, New Jersey, p.153-163.
5. Folstein, M.F., Folstein, S.E., McHugh, P.R., 1975. "Minimental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res., 12(3):189-198. [doi:10.1016/0022-3956(75) 90026-6]
6. Foltynie, T., Brayne, C., Barker, R.A., 2002. The heterogeneity of idiopathic Parkinson's disease. J. Neurol., 249(2): 138-145. [doi:10.1007/PL00007856] (Pubitemid 34143467)
7. Gibb, W.R., Lees, A.J., 1988. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J. Neurol. Neurosurg. Psychiatry, 51(6):745-752. [doi:10. 1136/jnnp.51.6.745]
8. Giovannini, P., Piccolo, I., Genitrini, S., Soliveri, P., Girotti, F., Geminiani, G., Scigliano, G., Caraceni, T., 1991. Earlyonset Parkinson's disease. Mov. Disord., 6(1):36-42. [doi: 10.1002/mds.870060107]
9. Golbe, L.I., 1993. Risk factors in young-onset Parkinson's disease. Neurology, 43(9):1641-1643. (Pubitemid 23307928)
10. Graham, J.M., Sagar, H.J., 1999. A data-driven approach to the study of heterogeneity in idiopathic Parkinson's disease: identification of three distinct subtypes. Mov. Disord., 14(1):10-20. [doi:10.1002/1531-8257(199901)14: 1<10:: AID-MDS1005>3.0.CO;2-4] (Pubitemid 29224671)
11. Hamilton, M., 1960. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry, 23(1):56-62. [doi:10.1136/jnnp. 23.1.56]
12. Harrison, M.B., Wylie, S.A., Frysinger, R.C., Patrie, J.T., Huss, D.S., Currie, L.J., Wooten, G.F., 2009. UPDRS activity of daily living score as a marker of Parkinson's disease progression. Mov. Disord., 24(2):224-230. [doi:10.1002/ mds.22335]
13. Hoehn, M.M., Yahr, M.D., 1967. Parkinsonism: onset, progression and mortality. Neurology, 17(5):427-442.
14. Hughes, A.J., Daniel, S.E., Blankson, S., Lees, A.J., 1993. A clinicopathologic study of 100 cases of Parkinson's disease. Adv. Neurol., 50(2):140-148. (Pubitemid 23054795)
15. Jankovic, J., McDermott, M., Carter, J., Gauthier, S., Goetz, C., Golbe, L., Huber, S., Koller, W., Olanow, C., Shoulson, I., et al., 1990. Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group. Neurology, 40(10):1529-1534. (Pubitemid 20351344)
16. Jellinger, K.A., 2002. Recent developments in the pathology of Parkinson's disease. J. Neural Transm. Suppl., (62): 347-376. (Pubitemid 37046679)
17. Krupp, L.B., LaRocca, N.G., Muir-Nash, J., Steinberg, A.D., 1989. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch. Neurol., 46(10):1121-1123. (Pubitemid 19246303)
18. Lewis, S.J., Dove, A., Robbins, T.W., Barker, R.A., Owen, A.M., 2003. Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry. J. Neurosci., 23(15): 6351-6356. (Pubitemid 36875637)
19. Lewis, S.J., Foltynie, T., Blackwell, A.D., Robbins, T.W., Owen, A.M., Barker, R.A., 2005. Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach. J. Neurol. Neurosurg. Psychiatry, 76(3): 343-348. [doi:10.1136/jnnp.2003.033530] (Pubitemid 40299121)
20. Li, G., Shen, Y.C., Chen, C.H., Li, S.R., Zhao, Y.W., Liu, M., Xu, L., Wang, L.X., Wang, Q., 1988. Preliminary application of MMSE in the aged of urban population in Beijing. Chin. Mental Health J., 2(1):13-18 (in Chinese).
21. Nazem, S., Siderowf, A.D., Duda, J.E., Have, T.T., Colcher, A., Horn, S.S., Moberg, P.J., Wilkinson, J.R., Hurtig, H.I., Stern, M.B., et al., 2009. Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score. J. Am. Geriatr. Soc., 57(2):304-308. [doi:10.1111/j.1532- 5415.2008.02096.x]
22. Post, B., Speelman, J.D., de Haan, R.J., 2008. Clinical heterogeneity in newly diagnosed Parkinson's disease, J. Neurol., 255(5):716-722. [doi:10.1007/s00415-008-0782-1]
23. Reijnders, J.S., Ehrt, U., Lousberg, R., Aarsland, D., Leentjens, A.F., 2009. The association between motor subtypes and psychopathology in Parkinson's disease. Parkinsonism Relat. Disord., 15(5):379-382. [doi:10.1016/j.parkreldis. 2008.09.003]
24. Selikhova, M., Williams, D.R., Kempster, P.A., Holton, J.L., Revesz, T., Lees, A.J., 2009. A clinico-pathological study of subtypes in Parkinson's disease. Brain, 132(Pt 11): 2947-2957. [doi:10.1093/brain/awp234]
25. Smyth, C., 2003. The pittsburgh sleep quality index. Dermatol. Nurs., 15(2):195-196.
26. Thompson, W.G., Longstreth, G.F., Drossman, D.A., Heaton, K.W., Irvine, E.J., Muller-Lissner, S.A., 1999. Functional bowel disorders and functional abdominal pain. Gut, 45(Suppl. 2):II43-II47. [doi:10.1136/gut.45.2008.ii43] (Pubitemid 29434812)
27. van Rooden, S.M., Visser, M., Verbaan, D., Marinus, J., van Hilten, J.J., 2009a. Motor patterns in Parkinson's disease: a data-driven approach. Mov. Disord., 24(7): 1042-1047. [doi:10.1002/mds.22512]
28. van Rooden, S.M., Visser, M., Verbaan, D., Marinus, J., van Hilten, J.J., 2009b. Patterns of motor and non-motor features in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry, 80(8):846-850. [doi:10.1136/jnnp.2008.166629]
29. van Rooden, S.M., Heiser, W.J., Kok, J.N., Verbaan, D., van Hilten, J.J., Marinus, J., 2010. The identification of Parkinson's disease subtypes using cluster analysis: a systematic review. Mov. Disord., 25(8):969-978. [doi: 10.1002/mds.23116]
30. Williams, L.N., Seignourel, P., Crucian, G.P., Okun, M.S., Rodriguez, R.L., Skidmore, F.M., Foster, P.S., Jacobson, C.E.4th, Romrell, J., Bowers, D., et al., 2007. Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease. Mov. Disord., 22(1):141-145. [doi:10.1002/mds.21220] (Pubitemid 46382690)
31. Zetusky, W.J., Jankovic, J., Pirozzolo, F.J., 1985. The heterogeneity of Parkinson's disease: clinical and prognostic implications. Neurology, 35(4):522-526. (Pubitemid 15085070)