Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke

Neurobiology of Disease

Volumn 45, Issue 1, 2012, Pages 624-632

  Li, Suk Yee ^a   Yang, Di ^a   Fu, Zhong Jie ^a   Woo, Tiffany ^a   Wong, David ^a,b   Lo, Amy Cheuk Yin ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Cerebral infarct; Inflammation; Ischemic stroke; Oxidative stress; Xanthophylls

Indexed keywords

3 NITROTYROSINE; CYCLOOXYGENASE 2; HEAT SHOCK PROTEIN 70; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BCL 2; PROTEIN HYDROLYSATE; PROTEIN KINASE B; TRIPHENYLTETRAZOLIUM; XANTHOPHYLL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIAPOPTOTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN SLICE; BRAIN TISSUE; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL LESION; NEUROLOGIC DISEASE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REPERFUSION INJURY; SCORING SYSTEM; STAINING; STROKE PATIENT; SURVIVAL RATE; TISSUE SECTION; WESTERN BLOTTING;

ANIMALS; BRAIN ISCHEMIA; CELL SURVIVAL; DISEASE MODELS, ANIMAL; LUTEIN; MALE; MICE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; STROKE;

EID: 81955167409     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.10.008     Document Type: Article

References (53)

1. Albayrak S., et al. Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury. Acta Neuropathol. 1997, 94:158-163.
2. Alves-Rodrigues A., Shao A. The science behind lutein. Toxicol. Lett. 2004, 150:57-83.
3. Ascherio A., et al. Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann. Intern. Med. 1999, 130:963-970.
4. Aslan M., et al. Nitrotyrosine formation and apoptosis in rat models of ocular injury. Free. Radic. Res. 2006, 40:147-153.
5. Chatterjee P.K., et al. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. FASEB J. 2000, 14:641-651.
6. Crack P.J., Taylor J.M. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 2005, 38:1433-1444.
7. Dagnelie G., et al. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. Optometry 2000, 71:147-164.
8. del Zoppo G.J., Mabuchi T. Cerebral microvessel responses to focal ischemia. J. Cereb. Blood Flow Metab. 2003, 23:879-894.
9. Donnan G.A., et al. Stroke. Lancet 2008, 371:1612-1623.
10. Egi Y., et al. Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia. Brain Res. 2011, 1389:169-176.
11. El-Remessy A.B., et al. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-d-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. Am. J. Pathol. 2003, 163:1997-2008.
12. Erdelyi K., et al. Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation. Cell. Mol. Life Sci. 2005, 62:751-759.
13. Feinstein D.L., et al. Heat shock protein 70 suppresses astroglial-inducible nitric-oxide synthase expression by decreasing NFkappaB activation. J. Biol. Chem. 1996, 271:17724-17732.
14. Franklin K.B.J., Paxinos G. The Mouse Brain in Sterotaxic Coordinates 1997, Academic Press, San Diego.
15. Giffard R.G., Yenari M.A. Many mechanisms for hsp70 protection from cerebral ischemia. J. Neurosurg. Anesthesiol. 2004, 16:53-61.
16. Harikumar K.B., et al. Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta). Int. J. Toxicol. 2008, 27:1-9.
17. Hickenbottom S.L., Barsan W.G. Acute ischemic stroke therapy. Neurol. Clin. 2000, 18:379-397.
18. Huang Z., et al. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994, 265:1883-1885.
19. Kelly S., et al. Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2. Ann. Neurol. 2002, 52:160-167.
20. Khachik F., et al. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem. 1997, 69:1873-1881.
21. Khachik F., et al. Chronic ingestion of (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the female rhesus macaque. Invest. Ophthalmol. Vis. Sci. 2006, 47:5476-5486.
22. Krinsky N.I. Possible biologic mechanisms for a protective role of xanthophylls. J. Nutr. 2002, 132:540S-542S.
23. Lakhan S.E., et al. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J. Transl. Med. 2009, 7:97.
24. Landrum J.T., Bone R.A. Lutein, zeaxanthin, and the macular pigment. Arch. Biochem. Biophys. 2001, 385:28-40.
25. Li S.Y., Lo A.C. Lutein protects RGC-5 cells against hypoxia and oxidative stress. Int. J. Mol. Sci. 2010, 11:2109-2117.
26. Li S.Y., et al. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest. Ophthalmol. Vis. Sci. 2009, 50:836-843.
27. Li S.Y., et al. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One 2011, 6:e16380.
28. Lo A.C., et al. Endothelin-1 over-expression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet. J. Cereb. Blood Flow Metab. 2005, 25:998-1101.
29. Lo A.C., et al. Deletion of aldose reductase leads to protection against cerebral ischemic injury. J. Cereb. Blood Flow Metab. 2007, 27:1496-1509.
30. McCall D.O., et al. Dietary intake of fruits and vegetables improves microvascular function in hypertensive subjects in a dose-dependent manner. Circulation 2009, 119:2153-2160.
31. Mehta S.L., et al. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev. 2007, 54:34-66.
32. Namura S., et al. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:11569-11574.
33. Noshita N., et al. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 2001, 21:1442-1450.
34. Noshita N., et al. Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J. Neurosci. 2002, 22:7923-7930.
35. Nurmi A., et al. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke 2004, 35:987-991.
36. Parker R.S. Carotenoids in human blood and tissues. J. Nutr. 1989, 119:101-104.
37. Polidori M.C., et al. Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome. Free. Radic. Res. 2002, 36:265-268.
38. Rajdev S., et al. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann. Neurol. 2000, 47:782-791.
39. Ravishankar G.A., et al. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model. J. Agric. Food. Chem. 2010, 58:8553-8559.
40. Ribaya-Mercado J.D., Blumberg J.B. Lutein and zeaxanthin and their potential roles in disease prevention. J. Am. Coll. Nutr. 2004, 23:567S-587S.
41. Richer S., et al. LAST II: differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry 2007, 78:213-219.
42. Ridder D.A., Schwaninger M. NF-kappaB signaling in cerebral ischemia. Neuroscience 2009, 158:995-1006.
43. Saleh A., et al. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat. Cell Biol. 2000, 2:476-483.
44. Schneider A., et al. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat. Med. 1999, 5:554-559.
45. Sommerburg O., et al. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br. J. Ophthalmol. 1998, 82:907-910.
46. Song Y.S., et al. The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2008, 28:1917-1926.
47. Song Y.S., et al. Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2010, 30:1265-1274.
48. White B.C., et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci. 2000, 179:1-33.
49. Yang X.Y., et al. Neuroprotective effect of dauricine after transient middle cerebral artery occlusion in rats: involvement of Bcl-2 family proteins. Am. J. Chin. Med. 2010, 38:307-318.
50. Yeung C.M., et al. More severe type 2 diabetes-associated ischemic stroke injury is alleviated in aldose reductase-deficient mice. J. Neurosci. Res. 2010, 88:2026-2034.
51. Zhan X., et al. Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke 2010, 41:538-543.
52. Zhang X., et al. Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats. Brain Res. 2010, 1343:143-152.
53. Zhou Z.Y., et al. Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats. J. Ethnopharmacol. 2010, 131:154-164.