Risk of convulsions in children after monovalent H1N1 (2009) and trivalent influenza vaccines: A database study

Vaccine

Volumn 29, Issue 51, 2011, Pages 9467-9472

  Stowe, Julia ^a   Andrews, Nick ^a   Bryan, Phil ^b   Seabroke, Suzie ^b   Miller, Elizabeth ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY   (United Kingdom)

Author keywords

Convulsions; Influenza vaccine; Monovalent H1N1 vaccine; Self controlled case series method; Vaccine associated adverse events

Indexed keywords

INFLUENZA VACCINE;

2009 H1N1 INFLUENZA; ARTICLE; CHILD; CONTROLLED STUDY; CONVULSION; DATA BASE; FEVER; HUMAN; INCIDENCE; INFANT; INFLUENZA VACCINATION; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

CHILD; CHILD, PRESCHOOL; FEMALE; FEVER; HUMANS; INFANT; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; SEIZURES;

EID: 81955164732     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.10.029     Document Type: Article

References (25)

1. Miller E., Andrews N., Stowe J., Grant A., Waight P., Taylor B. Risks of convulsion and aspectic meningits following measles-mumps-rubella vaccination in the United Kingdom. Am J Epidemiol 2007, 165:704-709.
2. Vestergaard M., Hviid A., Madsen K.M., Wohlfahrt J., Thorsen P., Schendel D., et al. MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis. JAMA 2004, 292(July (3)):351-357.
3. Barlow W.E., Davis R.L., Glasser J.W., Rhodes P.H., Thompson R.S., Mullooly J.P., et al. The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine. N Engl J Med 2001, 345(9):656-661.
4. Farrington P., Pugh S., Colville A., Flower A., Nash J., Morgan-Capner P., et al. A new method for active surveillance of adverse events from diphtheria/tetanus/pertussis and measles/mumps rubella vaccine. Lancet 1995, 345:567-569.
5. Nick Andrews, Julia Stowe, Lesley Wise, Elizabeth Miller Post licensure comparison of the safety profile of diphtheria/tetanus/whole cell pertussis/haemophilus influenza type b vaccine and a 5 in 1 diphtheria/tetanus/acellular pertussis/haemophilus influenza type b/polio vaccine in the United Kingdom. Vaccine 2010, 28(Oct 18 (44)):7215-7220. [Epub 2010 Aug 26].
6. Le Saux N., Barrowman N.J., Moore D.L., Whiting S., Scheifele D., Halperin S. Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACT. Pediatrics 2003, 112(5):e348.
7. Davis R.L., Kolczak M., Lewis E., Nordin J., Goodman M., Shay D., et al. Active surveillance of vaccine safety: a system to detect early signs of adverse events. Epidemiology 2005, 16:336-341.
8. Waddington C., Andrews N., Hoschler K., Walker W., Oeser C., Reiner A., et al. Open-label, randomised, parallel-group, multicentre study to evaluate the safety, tolerability and immunogenicity of an AS03(B)/oil-in-water emulsion-adjuvanted (AS03(B)) split-virion versus non-adjuvanted whole-virion H1N1 influenza vaccine in UK children 6 months to 12 years of age. Health Technol Assess 2010, 14(October (46)):1-130.
9. The H1N1 swine flu vaccination programme 2009-2010 Chief Medical Officer Letter, Department of Health 15 October 2009. http://www.dh.gov.uk/en/Publicationsandstatistics/Lettersandcirculars/Dearcolleagueletters/DH_107169.
10. A (H1N1) swine flu influenza: phase two of the vaccination programme; children over 6 months and under 5 years Chief Medical Officer Letter, Department of Health, 8 December 2009. http://www.dh.gov.uk/en/Publicationsandstatistics/Lettersandcirculars/Dearcolleagueletters/DH_109826.
11. Hospital Episode Statistics. The Health and Social Care Information Centre http://www.hesonline.org.uk/.
12. Skowronski D.M., Strauss B., De Serres G., MacDonald D., Marion S.A., Naus M., et al. Oculo-respiratory syndrome: a new influenza vaccine-associated adverse event?. Clin Infect Dis 2003, 36(March (6)):705-713. [Epub 2003 Mar 5].
13. Andrews N., Waight P., Yung C.F., Miller E. Age-specific effectiveness of an oil-in-water adjuvanted pandemic (H1N1) 2009 vaccine against confirmed infection in high risk groups in England. J Infect Dis 2011, 203(January (1)):32-39.
14. Bryan P., Seabroke S. No increased risk of febrile convulsions after seasonal. influenza immunisation in UK. Lancet 2011, 377(March (9769)):904. [PubMed PMID: 21397766].
15. MHRA Swine flu pandemic vaccines and antivirals: safety review Drug Safety Update-pandemic vaccines and antivirals: safety review October 2010 http://www.mhra.gov.uk/swineflu.
16. Australian Government. Department of Health and Ageing. Seasonal flu vaccine and young children. 23 April 2010. Media Release [available from:]. http://www.health.gov.au/internet/main/publishing.nsf/Content/mr-yr10-dept-dept230410.htm.
17. Australian Government. Department of Health and Ageing Investigation into febrile reactions in young children following 2010 seasonal trivalent influenza vaccination Status report as at 2 July 2010 [available from:]. http://www.tga.gov.au/alerts/medicines/fluvaccine-report100702.htm.
18. Kelly H., Carcione D., Dowse G., Effler P. Quantifying benefits and risks of vaccinating Australian children aged six months to four years with trivalent inactivated seasonal influenza vaccine in 2010. Euro Surveill 2010, 15(Sep 16; (37)). pii: 19661.
19. Miller E., Waight P., Farrington C.P., Andrews N., Stowe J., Taylor B. Idiopathic thrombocytopenic purpura and MMR vaccine. Arch Dis Child 2001, 84(March (3)):227-229.
20. Stowe J., Andrews N., Wise L., Miller L. Investigation of the temporal association between Guillain-Barré syndrome and influenza vaccine and influenza-like illness using the UK General Practice Research Database. Am J Epidemiol 2009, 169(February (3)):382-388.
21. Stowe J., Andrews N., Taylor B., Miller E. No evidence of an increase of bacterial and viral infections following measles, mumps and rubella vaccine. Vaccine 2009, 27(February (9)):1422-1425.
22. Chiu S.S., Tse C.Y., Lau Y.L., Peiris M. Influenza A and infection is an important cause of febrile seizures. Pediatrics 2001, 108(October (4)):E63.
23. Kwong K.L., Lam S.Y., Que T.L., Wong S.N. Influenza A and febrile seizures in childhood. Pediatr Neurol 2006, 35(December (6)):395-399.
24. Moore D.L., Vaudry W., Scheifele D.W., Halperin S.A., Déry P., Ford-Jones E., et al. Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004. Pediatrics 2006, 118(September (3)):e610-e619.
25. Pandemic H1N1 (Swine) influenza vaccine uptake amongst patient groups in primary care in England Report commissioned by DH and written by Monica Sethi & Richard Pebody (HPA) October 2010 http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_121011.