Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study

Journal of Dermatology

Volumn 38, Issue 12, 2011, Pages 1163-1166

  Kobayashi, Miwa ^a   Nakagawa, Tomoko ^b   Fukamachi, Kouichiro ^c   Nakamura, Motonobu ^a   Tokura, Yoshiki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b Nakagawa Clinic   (Japan)

^c Fukamachi Dermatology Clinic   (Japan)

Author keywords

acne; adapalene; antibiotics; nadifloxacin; randomized study

Indexed keywords

ADAPALENE; NADIFLOXACIN;

ACNE VULGARIS; ADOLESCENT; ADULT; APPLICATION SITE DRYNESS; ARTICLE; BURNING SENSATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ERYTHEMA; FEMALE; HUMAN; JAPANESE; MALE; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; TREATMENT DURATION; TREATMENT RESPONSE;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; CHILD; DERMATOLOGIC AGENTS; DRUG THERAPY, COMBINATION; FEMALE; FLUOROQUINOLONES; HUMANS; MALE; NAPHTHALENES; QUINOLIZINES; RETINOIDS; YOUNG ADULT;

EID: 81855217526     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2011.01280.x     Document Type: Article

References (28)

1. Weiss JS, Shavin JS,. Topical retinoid and antibiotic combination therapy for acne management. J Drugs Dermatol 2004; 3: 146-154.
2. Leyden JJ, Marples RR, Mills OH, et al. Tretinoin and antibiotic therapy in acne vulgaris. South Med J 1974; 67: 20-25.
3. Wolf JE Jr, Kaplan D, Kraus SJ, et al. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. J Am Acad Dermatol 2003; 49: S211-S217.
4. Thiboutot DM, Shalita AR, Yamauchi PS, et al. Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study. Skinmed 2005; 4: 138-146.
5. Cunliffe WJ, Meynadier J, Alirezai M, et al. Is combined oral and topical therapy better than oral therapy alone in patients with moderate to moderately severe acne vulgaris? A comparison of the efficacy and safety of lymecycline plus adapalene gel 0.1%, versus lymecycline plus gel vehicle. J Am Acad Dermatol 2003; 49: S218-S226.
6. Plewig G, Holland KT, Nenoff P,. Clinical and bacteriological evaluation of nadifloxacin 1% cream in patients with acne vulgaris: a double-blind, phase III comparison study versus erythromycin 2% cream. Eur J Dermatol 2006; 16: 48-55.
7. Kurokawa I, Akamatsu H, Nishijima S, et al. Clinical and bacteriologic evaluation of OPC-7251 in patients with acne: a double-blind group comparison study versus cream base. J Am Acad Dermatol 1991; 25: 674-681.
8. Muto N, Mitoh Y, Yamamoto I,. Development of a sensitive enzyme immunoassay for OPC-7251, a novel antimicrobial agent for percutaneous application. J Immunoassay 1990; 11: 1-16.
9. Alba V, Urban E, Angeles Dominguez M, et al. In vitro activity of nadifloxacin against several Gram-positive bacteria and analysis of the possible evolution of resistance after 2 years of use in Germany. Int J Antimicrob Agents 2009; 33: 272-275.
10. Hayashi N, Akamatsu H, Kawashima M,. Establishment of grading criteria for acne severity. J Dermatol 2008; 35: 255-260.
11. Kim J, Ochoa MT, Krutzik SR, et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 169: 1535-1541.
12. Zouboulis CC, Baron JM, Bohm M, et al. Frontiers in sebaceous gland biology and pathology. Exp Dermatol 2008; 17: 542-551.
13. Papakonstantinou E, Aletras AJ, Glass E, et al. Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol 2005; 125: 673-684.
14. Ottaviani M, Alestas T, Flori E, et al. Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. J Invest Dermatol 2006; 126: 2430-2437.
15. Kellett N, West F, Finlay AY,. Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial. Br J Dermatol 2006; 154: 524-532.
16. Saihan EM, Burton JL, Meyrick G, et al. The effect of a topical antibiotic preparation in acne vulgaris-a controlled clinical and laboratory study. Br J Clin Pract 1981; 35: 106-109.
17. Nishijima S, Kurokawa I, Katoh N, et al. The bacteriology of acne vulgaris and antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne lesions. J Dermatol 2000; 27: 318-323.
18. Nord CE, Oprica C,. Antibiotic resistance in Propionibacterium acnes. Microbiological and clinical aspects. Anaerobe 2006; 12: 207-210.
19. Oizumi N, Kawabata S, Hirao M, et al. Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin resistance in clinically isolated quinolone-resistant Staphylococcus aureus. J Infect Chemother 2001; 7: 191-194.
20. Akamatsu H, Sasaki H, Kurokawa I, et al. Effect of nadifloxacin on neutrophil functions. J Int Med Res 1995; 23: 19-26.
21. Kuwahara K, Kitazawa T, Kitagaki H, et al. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. J Dermatol Sci 2005; 38: 47-55.
22. Murata K, Sugita K, Kobayashi M, et al. Nadifloxacin downmodulates antigen-presenting functions of epidermal Langerhans cells and keratinocytes. J Dermatol Sci 2006; 42: 91-99.
23. Sugisaki H, Yamanaka K, Kakeda M, et al. Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. J Dermatol Sci 2009; 55: 47-52.
24. Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009; 18: 821-832.
25. Bastos LF, Merlo LA, Rocha LT, et al. Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models. Eur J Pharmacol 2007; 576: 171-179.
26. Scaglione F, Rossoni G,. Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin. J Antimicrob Chemother 1998; 41 (Suppl B): 47-50.
27. Del Rosso JQ, Schmidt NF,. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis 2010; 85: 15-24.
28. Umeki S,. Anti-inflammatory action of erythromycin. Its inhibitory effect on neutrophil NADPH oxidase activity. Chest 1993; 104: 1191-1193.